Clinically relevant doses of FLT3-kinase inhibitors quizartinib and midostaurin do not impair T-cell reactivity and function.

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Published in Haematologica on March 14, 2014

Authors

Denise Wolleschak1, Thomas S Mack1, Florian Perner1, Stephanie Frey1, Tina M Schnöder1, Marie-Christine Wagner1, Christine Höding1, Marina C Pils2, Andreas Parkner3, Stefanie Kliche4, Burkhart Schraven5, Katrin Hebel6, Monika Brunner-Weinzierl6, Satish Ranjan7, Berend Isermann7, Daniel B Lipka8, Thomas Fischer1, Florian H Heidel9

Author Affiliations

1: Department of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
2: Mousepathology, Animal Experimental Unit, Helmholtz-Center for Infection Research, Braunschweig, Germany.
3: Department of Transfusion Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
4: Institute of Molecular and Clinical Immunology, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
5: Institute of Molecular and Clinical Immunology, Otto-von-Guericke University Medical Center, Magdeburg, Germany Department of Immune Control, Helmholtz Center for Infection Research, Braunschwei, Germany.
6: Department of Experimental Pediatrics, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
7: Institute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke University Medical Center, Magdeburg, Germany.
8: Department of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany German Cancer Research Center (DKFZ), Division of Epigenomics and Cancer Risk Factors, Heidelberg, Germany.
9: Department of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Medical Center, Magdeburg, Germany florian.h.heidel@gmail.com.

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