Published in PLoS One on March 17, 2014
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Companion animals: Translational scientist's new best friends. Sci Transl Med (2015) 0.82
In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: translational implications for human tumors. BMC Cancer (2015) 0.79
Defining the Value of a Comparative Approach to Cancer Drug Development. Clin Cancer Res (2015) 0.77
Precision medicine: an opportunity for a paradigm shift in veterinary medicine. J Am Vet Med Assoc (2016) 0.75
Multi-drug analyses in patients distinguish efficacious cancer agents based on both tumor cell killing and immunomodulation. Cancer Res (2017) 0.75
The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science (2006) 25.99
Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature (2005) 23.04
How many drug targets are there? Nat Rev Drug Discov (2006) 14.22
DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res (2010) 13.68
Chemosensitivity prediction by transcriptional profiling. Proc Natl Acad Sci U S A (2001) 7.51
Pilot study using molecular profiling of patients' tumors to find potential targets and select treatments for their refractory cancers. J Clin Oncol (2010) 6.34
Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study. Blood (2002) 4.00
A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery. Proc Natl Acad Sci U S A (2007) 3.78
Translation of new cancer treatments from pet dogs to humans. Nat Rev Cancer (2008) 3.23
Personalized medicine in a phase I clinical trials program: the MD Anderson Cancer Center initiative. Clin Cancer Res (2012) 3.14
Spontaneously occurring tumors of companion animals as models for human cancer. Cancer Invest (2000) 2.70
Evolution of an adenocarcinoma in response to selection by targeted kinase inhibitors. Genome Biol (2010) 2.60
Systems cancer medicine: towards realization of predictive, preventive, personalized and participatory (P4) medicine. J Intern Med (2012) 2.13
The dog as a cancer model. Nat Biotechnol (2006) 2.08
Genome and transcriptome sequencing in prospective metastatic triple-negative breast cancer uncovers therapeutic vulnerabilities. Mol Cancer Ther (2012) 1.72
Detection of DNA copy number changes and oncogenic signaling abnormalities from gene expression data reveals MYC activation in high-grade papillary renal cell carcinoma. Cancer Res (2007) 1.66
Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression. BMC Genomics (2009) 1.57
Identifying disease-specific genes based on their topological significance in protein networks. BMC Syst Biol (2009) 1.54
Launching a novel preclinical infrastructure: comparative oncology trials consortium directed therapeutic targeting of TNFalpha to cancer vasculature. PLoS One (2009) 1.33
Trastuzumab: a review of its use in the treatment of metastatic breast cancer overexpressing HER2. Drugs (2002) 1.18
Gene profiling of canine B-cell lymphoma reveals germinal center and postgerminal center subtypes with different survival times, modeling human DLBCL. Cancer Res (2013) 1.14
What are we learning from the cancer genome? Nat Rev Clin Oncol (2012) 1.13
How comparative effectiveness research can help advance 'personalized medicine' in cancer treatment. Health Aff (Millwood) (2011) 1.11
Molecular profiling of cancer--the future of personalized cancer medicine: a primer on cancer biology and the tools necessary to bring molecular testing to the clinic. Semin Oncol (2011) 1.05
Molecular diagnostics and personalized medicine in oncology: challenges and opportunities. J Cell Biochem (2013) 1.04
A compendium of canine normal tissue gene expression. PLoS One (2011) 0.97
Screening a panel of drugs with diverse mechanisms of action yields potential therapeutic agents against neuroblastoma. Cancer Biol Ther (2009) 0.96
Rapamycin pharmacokinetic and pharmacodynamic relationships in osteosarcoma: a comparative oncology study in dogs. PLoS One (2010) 0.92
Mouse models of cancers: opportunities to address heterogeneity of human cancer and evaluate therapeutic strategies. J Mol Med (Berl) (2010) 0.92
Personalized medicine in oncology: a personal view with myths and facts. Curr Clin Pharmacol (2010) 0.81
Clinical cancer genome and precision medicine. Ann Surg Oncol (2012) 0.80
Gene expression significance in personalized medicine of non-small-cell lung cancer and gene expression analyzing platforms. Curr Drug Metab (2011) 0.80
A multi-site feasibility study for personalized medicine in canines with osteosarcoma. J Transl Med (2013) 0.79
Defining the Pharmacodynamic Profile and Therapeutic Index of NHS-IL12 Immunocytokine in Dogs with Malignant Melanoma. PLoS One (2015) 0.77
A Comparative Oncology Study of Iniparib Defines Its Pharmacokinetic Profile and Biological Activity in a Naturally-Occurring Canine Cancer Model. PLoS One (2016) 0.75