PubRank

John O Holloszy

Author PubWeight™ 116.54‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol 2005 5.80
2 Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1. FASEB J 2002 4.75
3 Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. Proc Natl Acad Sci U S A 2004 4.60
4 Long-term caloric restriction ameliorates the decline in diastolic function in humans. J Am Coll Cardiol 2006 3.29
5 Respiratory uncoupling lowers blood pressure through a leptin-dependent mechanism in genetically obese mice. Arterioscler Thromb Vasc Biol 2002 3.01
6 Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans. Aging Cell 2008 2.87
7 Effects of exercise training on frailty in community-dwelling older adults: results of a randomized, controlled trial. J Am Geriatr Soc 2002 2.80
8 High-fat diets cause insulin resistance despite an increase in muscle mitochondria. Proc Natl Acad Sci U S A 2008 2.65
9 Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial. Am J Clin Nutr 2006 2.57
10 Exercise-induced mitochondrial biogenesis begins before the increase in muscle PGC-1alpha expression. J Biol Chem 2006 2.51
11 Bone mineral density response to caloric restriction-induced weight loss or exercise-induced weight loss: a randomized controlled trial. Arch Intern Med 2006 2.37
12 One year of caloric restriction in humans: feasibility and effects on body composition and abdominal adipose tissue. J Gerontol A Biol Sci Med Sci 2006 2.31
13 A role for the transcriptional coactivator PGC-1alpha in muscle refueling. J Biol Chem 2007 2.19
14 A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes. Cell Metab 2005 2.14
15 Normal adaptations to exercise despite protection against oxidative stress. Am J Physiol Endocrinol Metab 2011 1.93
16 Activation of AMP kinase enhances sensitivity of muscle glucose transport to insulin. Am J Physiol Endocrinol Metab 2002 1.88
17 Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized, controlled trial. Am J Physiol Endocrinol Metab 2007 1.85
18 Design and conduct of the CALERIE study: comprehensive assessment of the long-term effects of reducing intake of energy. J Gerontol A Biol Sci Med Sci 2010 1.80
19 Long-term low-protein, low-calorie diet and endurance exercise modulate metabolic factors associated with cancer risk. Am J Clin Nutr 2006 1.75
20 Calcium induces increases in peroxisome proliferator-activated receptor gamma coactivator-1alpha and mitochondrial biogenesis by a pathway leading to p38 mitogen-activated protein kinase activation. J Biol Chem 2007 1.71
21 Lower extremity muscle size and strength and aerobic capacity decrease with caloric restriction but not with exercise-induced weight loss. J Appl Physiol (1985) 2006 1.68
22 Effect of long-term calorie restriction with adequate protein and micronutrients on thyroid hormones. J Clin Endocrinol Metab 2006 1.64
23 Ca2+ and AMPK both mediate stimulation of glucose transport by muscle contractions. Diabetes 2004 1.60
24 Raising plasma fatty acid concentration induces increased biogenesis of mitochondria in skeletal muscle. Proc Natl Acad Sci U S A 2007 1.58
25 Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production. Age (Dordr) 2009 1.57
26 Exercise induces an increase in muscle UCP3 as a component of the increase in mitochondrial biogenesis. Am J Physiol Endocrinol Metab 2002 1.57
27 Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial. JAMA 2004 1.51
28 Effects of 7 days of exercise training on insulin sensitivity and responsiveness in type 2 diabetes mellitus. Am J Physiol Endocrinol Metab 2009 1.50
29 Effects of progressive resistance training on body composition in frail older adults: results of a randomized, controlled trial. J Gerontol A Biol Sci Med Sci 2005 1.48
30 Effects of resveratrol and SIRT1 on PGC-1α activity and mitochondrial biogenesis: a reevaluation. PLoS Biol 2013 1.40
31 Abdominal adiposity is a stronger predictor of insulin resistance than fitness among 50-95 year olds. Diabetes Care 2006 1.26
32 Raising Ca2+ in L6 myotubes mimics effects of exercise on mitochondrial biogenesis in muscle. FASEB J 2003 1.25
33 Skeletal muscle overexpression of nuclear respiratory factor 1 increases glucose transport capacity. FASEB J 2003 1.24
34 Does calorie restriction induce mitochondrial biogenesis? A reevaluation. FASEB J 2010 1.23
35 Regulation of GLUT4 biogenesis in muscle: evidence for involvement of AMPK and Ca(2+). Am J Physiol Endocrinol Metab 2002 1.14
36 Activation of p38 MAP kinase enhances sensitivity of muscle glucose transport to insulin. Am J Physiol Endocrinol Metab 2004 1.13
37 Influence of weekend lifestyle patterns on body weight. Obesity (Silver Spring) 2008 1.12
38 Caloric restriction may reverse age-related autonomic decline in humans. Aging Cell 2012 1.10
39 DHEA enhances effects of weight training on muscle mass and strength in elderly women and men. Am J Physiol Endocrinol Metab 2006 1.09
40 Exercise: it's the real thing! Nutr Rev 2009 1.09
41 PPARdelta activator GW-501516 has no acute effect on glucose transport in skeletal muscle. Am J Physiol Endocrinol Metab 2005 1.06
42 Gender differences in the decline in aerobic capacity and its physiological determinants during the later decades of life. J Appl Physiol (1985) 2006 1.06
43 Role of calcineurin in exercise-induced mitochondrial biogenesis. Am J Physiol Endocrinol Metab 2006 1.05
44 Deficiency of the mitochondrial electron transport chain in muscle does not cause insulin resistance. PLoS One 2011 1.04
45 Contraction- and hypoxia-stimulated glucose transport is mediated by a Ca2+-dependent mechanism in slow-twitch rat soleus muscle. Am J Physiol Endocrinol Metab 2005 1.04
46 Calpain system regulates muscle mass and glucose transporter GLUT4 turnover. J Biol Chem 2004 1.04
47 Long-term calorie restriction, but not endurance exercise, lowers core body temperature in humans. Aging (Albany NY) 2011 1.04
48 UCP-mediated energy depletion in skeletal muscle increases glucose transport despite lipid accumulation and mitochondrial dysfunction. Am J Physiol Endocrinol Metab 2003 1.04
49 Long-term low-calorie low-protein vegan diet and endurance exercise are associated with low cardiometabolic risk. Rejuvenation Res 2007 1.02
50 Long-term effects of calorie restriction on serum sex-hormone concentrations in men. Aging Cell 2010 1.02
51 Aerobic power and insulin action improve in response to endurance exercise training in healthy 77-87 yr olds. J Appl Physiol (1985) 2005 1.01
52 Attenuation of cardiovascular adaptations to exercise in frail octogenarians. J Appl Physiol (1985) 2003 1.01
53 Prevention of glycogen supercompensation prolongs the increase in muscle GLUT4 after exercise. Am J Physiol Endocrinol Metab 2003 0.97
54 Ginseng and ginsenoside Re do not improve β-cell function or insulin sensitivity in overweight and obese subjects with impaired glucose tolerance or diabetes. Diabetes Care 2011 0.97
55 The effects of caloric restriction- and exercise-induced weight loss on left ventricular diastolic function. Am J Physiol Heart Circ Physiol 2007 0.95
56 How muscle insulin sensitivity is regulated: testing of a hypothesis. Am J Physiol Endocrinol Metab 2006 0.94
57 Improvements in body composition, glucose tolerance, and insulin action induced by increasing energy expenditure or decreasing energy intake. J Nutr 2007 0.93
58 IL-6 increases muscle insulin sensitivity only at superphysiological levels. Am J Physiol Endocrinol Metab 2007 0.93
59 Intermittent increases in cytosolic Ca2+ stimulate mitochondrial biogenesis in muscle cells. Am J Physiol Endocrinol Metab 2002 0.91
60 Glucose transport rate and glycogen synthase activity both limit skeletal muscle glycogen accumulation. Am J Physiol Endocrinol Metab 2002 0.90
61 PGC-1α mediates a rapid, exercise-induced downregulation of glycogenolysis in rat skeletal muscle. J Physiol 2014 0.89
62 Endothelial function after high-sugar-food ingestion improves with endurance exercise performed on the previous day. Am J Clin Nutr 2008 0.85
63 Dehydroepiandrosterone replacement therapy in older adults: 1- and 2-y effects on bone. Am J Clin Nutr 2009 0.85
64 Inhibition of calpain results in impaired contraction-stimulated GLUT4 translocation in skeletal muscle. Am J Physiol Endocrinol Metab 2006 0.84
65 Low bone mass in subjects on a long-term raw vegetarian diet. Arch Intern Med 2005 0.84
66 Dehydroepiandrosterone (DHEA) replacement decreases insulin resistance and lowers inflammatory cytokines in aging humans. Aging (Albany NY) 2011 0.84
67 Modest weight loss improves insulin action in obese African Americans. Metabolism 2005 0.83
68 Are tyrosine kinases involved in mediating contraction-stimulated muscle glucose transport? Am J Physiol Endocrinol Metab 2005 0.82
69 Dehydroepiandrosterone replacement therapy in older adults improves indices of arterial stiffness. Aging Cell 2012 0.82
70 Comparison of methods for assessing abdominal adipose tissue from magnetic resonance images. Obesity (Silver Spring) 2007 0.82
71 Calcineurin does not mediate exercise-induced increase in muscle GLUT4. Diabetes 2005 0.81
72 Phorbol esters affect skeletal muscle glucose transport in a fiber type-specific manner. Am J Physiol Endocrinol Metab 2004 0.80
73 Glucosamine and glucose induce insulin resistance by different mechanisms in rat skeletal muscle. Am J Physiol Endocrinol Metab 2003 0.80
74 Bayesian functional integral method for inferring continuous data from discrete measurements. Biophys J 2012 0.79
75 Multiple dietary supplements do not affect metabolic and cardio-vascular health. Aging (Albany NY) 2014 0.79
76 β-Adrenergic stimulation does not activate p38 MAP kinase or induce PGC-1α in skeletal muscle. Am J Physiol Endocrinol Metab 2013 0.78
77 Postprandial plasma incretin hormones in exercise-trained versus untrained subjects. Med Sci Sports Exerc 2014 0.78
78 Is "fat-induced" muscle insulin resistance rapidly reversible? Am J Physiol Endocrinol Metab 2009 0.77
79 A peroxovanadium compound stimulates muscle glucose transport as powerfully as insulin and contractions combined. Diabetes 2003 0.77
80 Urgent call for the third wish. Diabetes Metab Res Rev 2013 0.75
81 Ginsenoside Re rapidly reverses insulin resistance in muscles of high-fat diet fed rats. Metabolism 2012 0.75
82 Divergent effects of acute exercise and endurance training on UCP3 expression. Am J Physiol Endocrinol Metab 2003 0.75
83 Multiple dietary supplements do not affect metabolic and cardiovascular health. Aging (Albany NY) 2013 0.75