Individualization of chronic hepatitis C treatment according to the host characteristics.

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Published in World J Gastroenterol on March 21, 2014

Authors

Nikolaos K Gatselis1, Kalliopi Zachou1, Asterios Saitis1, Maria Samara1, George N Dalekos1

Author Affiliations

1: Nikolaos K Gatselis, Kalliopi Zachou, Asterios Saitis, George N Dalekos, Department of Medicine and Research Laboratory of Internal Medicine, School of Medicine, University of Thessaly, 41110 Larissa, Greece.

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Differences in treatment outcome for hepatitis C among ethnic groups. Am J Med (2004) 1.48

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Apolipoprotein-E and hepatitis C lipoviral particles in genotype 1 infection: evidence for an association with interferon sensitivity. J Hepatol (2012) 1.47

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