Amyloidosis associated with cerebral amyloid angiopathy: cell signaling pathways elicited in cerebral endothelial cells.

PubWeight™: 0.77‹?›

🔗 View Article (PMC 4467213)

Published in J Alzheimers Dis on January 01, 2014

Authors

Jorge Ghiso1, Silvia Fossati2, Agueda Rostagno2

Author Affiliations

1: Department of Pathology, New York University School of Medicine, New York, NY, USA Department of Psychiatry, New York University School of Medicine, New York, NY, USA.
2: Department of Pathology, New York University School of Medicine, New York, NY, USA.

Articles cited by this

Inflammation and Alzheimer's disease. Neurobiol Aging (2000) 12.56

The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron (2008) 10.19

A beta oligomers - a decade of discovery. J Neurochem (2007) 8.88

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders. Annu Rev Neurosci (2003) 8.44

The inflammatory response in myocardial infarction. Cardiovasc Res (2002) 7.92

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature (2009) 6.17

Inflammation in Alzheimer disease: driving force, bystander or beneficial response? Nat Med (2006) 6.15

Toxic proteins in neurodegenerative disease. Science (2002) 5.82

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation. Nat Neurosci (2001) 5.29

Rationalization of the effects of mutations on peptide and protein aggregation rates. Nature (2003) 4.98

Cell death. N Engl J Med (2009) 4.75

Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science (1990) 4.71

Apoptosis in neurodegenerative disorders. Nat Rev Mol Cell Biol (2000) 4.17

Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy. Ann Neurol (2001) 3.46

Complement activation by beta-amyloid in Alzheimer disease. Proc Natl Acad Sci U S A (1992) 2.84

Glial-neuronal interactions in Alzheimer's disease: the potential role of a 'cytokine cycle' in disease progression. Brain Pathol (1998) 2.73

Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene. Nat Genet (1992) 2.40

Interleukin-1 expression in different plaque types in Alzheimer's disease: significance in plaque evolution. J Neuropathol Exp Neurol (1995) 2.35

A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia. Ann Neurol (2008) 2.32

The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia. Acta Neuropathol (2010) 2.31

A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis. Science (2009) 2.30

Amyloid fibril protein nomenclature: 2012 recommendations from the Nomenclature Committee of the International Society of Amyloidosis. Amyloid (2012) 2.21

The cerebral beta-amyloid angiopathies: hereditary and sporadic. Brain Pathol (2006) 1.91

Complement-dependent proinflammatory properties of the Alzheimer's disease beta-peptide. J Exp Med (1998) 1.84

Alzheimer's disease. Cold Spring Harb Perspect Biol (2011) 1.81

Pathogenic effects of D23N Iowa mutant amyloid beta -protein. J Biol Chem (2001) 1.74

Substitutions at codon 22 of Alzheimer's abeta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells. J Biol Chem (2000) 1.71

Early onset familial Alzheimer's disease: Mutation frequency in 31 families. Neurology (2003) 1.71

Nitric oxide synthase activity is elevated in brain microvessels in Alzheimer's disease. Biochem Biophys Res Commun (1994) 1.69

Neurovascular dysfunction, inflammation and endothelial activation: implications for the pathogenesis of Alzheimer's disease. J Neuroinflammation (2011) 1.68

From Alzheimer to Huntington: why is a structural understanding so difficult? EMBO J (2003) 1.68

Molecular genetics of Alzheimer's disease: an update. Ann Med (2008) 1.62

Interleukins in atherosclerosis: molecular pathways and therapeutic potential. Pharmacol Rev (2003) 1.62

Inflammation and Alzheimer's disease. Arch Pharm Res (2010) 1.60

Beta-amyloid(1-42) induces neuronal death through the p75 neurotrophin receptor. J Neurosci (2008) 1.59

Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies. Acta Neuropathol (2009) 1.57

Inflammatory factors are elevated in brain microvessels in Alzheimer's disease. Neurobiol Aging (2001) 1.56

beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain. J Immunol (1994) 1.38

Review: sporadic cerebral amyloid angiopathy. Neuropathol Appl Neurobiol (2011) 1.37

Human endothelium as a source of multifunctional cytokines: molecular regulation and possible role in human disease. J Interferon Cytokine Res (1999) 1.33

The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo. J Neurosci (2009) 1.31

Amyloid beta binds trimers as well as monomers of the 75-kDa neurotrophin receptor and activates receptor signaling. J Biol Chem (2001) 1.23

Complement component C1q modulates the phagocytosis of Abeta by microglia. Exp Neurol (2000) 1.19

Familial Danish dementia: co-existence of Danish and Alzheimer amyloid subunits (ADan AND A{beta}) in the absence of compact plaques. J Biol Chem (2005) 1.18

Enhanced pathologic properties of Dutch-type mutant amyloid beta-protein. Proc Natl Acad Sci U S A (1996) 1.18

Down's syndrome, neuroinflammation, and Alzheimer neuropathogenesis. J Neuroinflammation (2013) 1.16

Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood. Neurobiol Aging (2002) 1.16

Amyloidosis and Alzheimer's disease. Adv Drug Deliv Rev (2002) 1.14

Cerebrovascular transforming growth factor-beta contributes to inflammation in the Alzheimer's disease brain. Am J Pathol (2002) 1.11

Beta-amyloid binds to p57NTR and activates NFkappaB in human neuroblastoma cells. J Neurosci Res (1998) 1.11

Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain. J Neurosci (2002) 1.09

Protein folding and its links with human disease. Biochem Soc Symp (2001) 1.08

Differential activation of mitochondrial apoptotic pathways by vasculotropic amyloid-beta variants in cells composing the cerebral vessel walls. FASEB J (2009) 1.08

Neurovascular defects and faulty amyloid-β vascular clearance in Alzheimer's disease. J Alzheimers Dis (2013) 1.07

Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway. Neurobiol Dis (2008) 1.07

Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimer's disease. J Neurol Neurosurg Psychiatry (2004) 1.06

Microglia, amyloid and dementia in alzheimer disease. A correlative study. Neurobiol Aging (2000) 1.05

Complement activation in chromosome 13 dementias. Similarities with Alzheimer's disease. J Biol Chem (2002) 1.04

The role of complement in Alzheimer's disease pathology. Biochim Biophys Acta (2000) 1.01

Mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis in Alzheimer's disease. J Pharmacol Sci (2005) 1.01

Dutch and Arctic mutant peptides of beta amyloid(1-40) differentially affect the FGF-2 pathway in brain endothelium. Exp Cell Res (2008) 1.01

Caspase-mediated degeneration in Alzheimer's disease. Am J Pathol (2004) 1.00

Complement in Alzheimer's disease: opportunities for modulating protective and pathogenic events. Neurobiol Aging (2001) 1.00

Hereditary cerebral hemorrhage with amyloidosis-Dutch type. Neuropathology (2005) 0.98

Cerebral amyloidosis: amyloid subunits, mutants and phenotypes. Cell Mol Life Sci (2009) 0.96

Tauroursodeoxycholic acid prevents E22Q Alzheimer's Abeta toxicity in human cerebral endothelial cells. Cell Mol Life Sci (2009) 0.96

Enhanced aggregation and beta structure of amyloid beta peptide after coincubation with C1q. J Neurosci Res (1994) 0.94

Cerebral amyloid angiopathy. Prog Mol Biol Transl Sci (2012) 0.93

Apoptotic gene expression in Alzheimer's disease hippocampal tissue. Am J Alzheimers Dis Other Demen (2007) 0.92

The role of inflammatory processes in Alzheimer's disease. Inflammopharmacology (2012) 0.92

The pathophysiology and clinical presentation of cerebral amyloid angiopathy. Curr Atheroscler Rep (2012) 0.91

Familial cerebral amyloid angiopathy related to stroke and dementia. Amyloid (2001) 0.90

A novel AbetaPP mutation exclusively associated with cerebral amyloid angiopathy. Ann Neurol (2005) 0.89

Coordinated expression of caspase 8, 3 and 7 mRNA in temporal cortex of Alzheimer disease: relationship to formic acid extractable abeta42 levels. J Neuropathol Exp Neurol (2006) 0.89

A DR6/p75(NTR) complex is responsible for β-amyloid-induced cortical neuron death. Cell Death Dis (2013) 0.89

Fibrillar amyloid beta-protein mediates the pathologic accumulation of its secreted precursor in human cerebrovascular smooth muscle cells. J Biol Chem (2000) 0.89

Focal inflammation in the brain: role in Alzheimer's disease. Immunol Res (2000) 0.88

The presence of complements in amyloid plaques of Creutzfeldt-Jakob disease and Gerstmann-Straussler-Scheinker disease. Appl Pathol (1984) 0.87

Iowa variant of familial Alzheimer's disease: accumulation of posttranslationally modified AbetaD23N in parenchymal and cerebrovascular amyloid deposits. Am J Pathol (2010) 0.86

TRAIL death receptors DR4 and DR5 mediate cerebral microvascular endothelial cell apoptosis induced by oligomeric Alzheimer's Aβ. Cell Death Dis (2012) 0.86

pH-dependent fibrillogenesis of a VkappaIII Bence Jones protein. Br J Haematol (1999) 0.85

Degeneration process of Lewy bodies in the brains of patients with dementia with Lewy bodies using alpha-synuclein-immunohistochemistry. Neurosci Lett (2000) 0.84

Protein aggregates and dementia: is there a common toxicity? J Neurol Neurosurg Psychiatry (2002) 0.84

A family with Alzheimer disease and strokes associated with A713T mutation of the APP gene. Neurology (2004) 0.83

Age-related plaque morphology and C-terminal heterogeneity of amyloid beta in Dutch-type hereditary cerebral hemorrhage with amyloidosis. Acta Neuropathol (2000) 0.82

Differential contribution of isoaspartate post-translational modifications to the fibrillization and toxic properties of amyloid β and the Asn23 Iowa mutation. Biochem J (2013) 0.80

Insights into caspase-mediated apoptotic pathways induced by amyloid-β in cerebral microvascular endothelial cells. Neurodegener Dis (2011) 0.79

Caspase-8 activation and oxidative stress are involved in the cytotoxic effect of beta-amyloid on rat brain microvascular endothelial cells. Int J Mol Med (2006) 0.79

Chromosome 13 dementia syndromes as models of neurodegeneration. Amyloid (2001) 0.78