Lesions from patients with sporadic cerebral cavernous malformations harbor somatic mutations in the CCM genes: evidence for a common biochemical pathway for CCM pathogenesis.

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Published in Hum Mol Genet on April 03, 2014

Authors

David A McDonald1, Changbin Shi2, Robert Shenkar2, Carol J Gallione1, Amy L Akers3, Stephanie Li1, Nicholas De Castro1, Michel J Berg4, David L Corcoran5, Issam A Awad2, Douglas A Marchuk6

Author Affiliations

1: Molecular Genetics and Microbiology Department, Duke University Medical Center, Durham, NC 27710, USA.
2: Section of Neurosurgery, Biological Sciences Division, University of Chicago, Chicago, IL 60637, USA.
3: Molecular Genetics and Microbiology Department, Duke University Medical Center, Durham, NC 27710, USA Angioma Alliance, Norfolk, VA 23517, USA.
4: School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14642, USA and.
5: Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA.
6: Molecular Genetics and Microbiology Department, Duke University Medical Center, Durham, NC 27710, USA douglas.marchuk@duke.edu.

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