PubRank

T J Ley

Author PubWeight™ 134.32‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Recurrent DNMT3A mutations in patients with myelodysplastic syndromes. Leukemia 2011 4.28
2 Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell 1994 4.26
3 Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus. Genes Dev 1995 4.11
4 Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis. Nat Med 1998 4.04
5 The physician-scientist: career issues and challenges at the year 2000. FASEB J 2000 3.38
6 5-azacytidine selectively increases gamma-globin synthesis in a patient with beta+ thalassemia. N Engl J Med 1982 3.29
7 RNA processing errors in patients with beta-thalassemia. Proc Natl Acad Sci U S A 1982 2.99
8 Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice. Proc Natl Acad Sci U S A 1996 2.93
9 Clonal diversity of recurrently mutated genes in myelodysplastic syndromes. Leukemia 2013 2.85
10 Long-range disruption of gene expression by a selectable marker cassette. Proc Natl Acad Sci U S A 1996 2.83
11 Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR alpha under control of cathepsin G regulatory sequences. Blood 1997 2.72
12 Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages. J Biol Chem 1993 2.56
13 Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo. Proc Natl Acad Sci U S A 1999 2.48
14 Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I. Proc Natl Acad Sci U S A 1995 2.43
15 Inducible transcription of five globin genes in K562 human leukemia cells. Proc Natl Acad Sci U S A 1983 2.35
16 Analysis of mice containing a targeted deletion of beta-globin locus control region 5' hypersensitive site 3. Mol Cell Biol 1996 2.17
17 Beta O-39 thalassemia gene: a premature termination codon causes beta-mRNA deficiency without affecting cytoplasmic beta-mRNA stability. Blood 1984 2.17
18 An enhancer element lies 3' to the human A gamma globin gene. EMBO J 1987 2.11
19 Conservation of the primary structure, organization, and function of the human and mouse beta-globin locus-activating regions. Proc Natl Acad Sci U S A 1990 1.89
20 How do cytotoxic lymphocytes kill their targets? Curr Opin Immunol 1998 1.80
21 Seed versus soil: the importance of the target cell for transgenic models of human leukemias. Blood 1999 1.73
22 fgr proto-oncogene mRNA induced in B lymphocytes by Epstein-Barr virus infection. Nature 1986 1.64
23 5-Azacytidine increases gamma-globin synthesis and reduces the proportion of dense cells in patients with sickle cell anemia. Blood 1983 1.61
24 Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells. Proc Natl Acad Sci U S A 1995 1.59
25 Dipeptidyl peptidase I is essential for activation of mast cell chymases, but not tryptases, in mice. J Biol Chem 2001 1.57
26 Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase. J Biol Chem 1992 1.57
27 Normal neutrophil function in cathepsin G-deficient mice. Blood 1999 1.53
28 DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis. Immunity 2000 1.52
29 Genomic organization and chromosomal localization of the human cathepsin G gene. J Biol Chem 1989 1.52
30 Advances in thalassemia research. Blood 1984 1.52
31 A bcr-3 isoform of RARalpha-PML potentiates the development of PML-RARalpha-driven acute promyelocytic leukemia. Proc Natl Acad Sci U S A 1999 1.50
32 Functional properties of the beta-globin locus control region in K562 erythroleukemia cells. Blood 1991 1.48
33 Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation. J Clin Invest 1997 1.45
34 Granzyme A initiates an alternative pathway for granule-mediated apoptosis. Immunity 1999 1.37
35 Transgenic analysis of a 100-kb human beta-globin cluster-containing DNA fragment propagated as a bacterial artificial chromosome. Blood 1999 1.32
36 Acquired, nonrandom chromosomal abnormalities associated with the development of acute promyelocytic leukemia in transgenic mice. Proc Natl Acad Sci U S A 2000 1.30
37 Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK. Proc Natl Acad Sci U S A 2001 1.23
38 Sudden death among patients with acute promyelocytic leukemia treated with arsenic trioxide. Blood 2001 1.22
39 A weak upstream promoter gives rise to long human beta-globin RNA molecules. Biochem Biophys Res Commun 1983 1.20
40 Developmental regulation of the human cathepsin G gene in myelomonocytic cells. J Biol Chem 1990 1.19
41 Function of normal and mutated gamma-globin gene promoters in electroporated K562 erythroleukemia cells. Blood 1990 1.18
42 Structure and function of the murine beta-globin locus control region 5' HS-3. Nucleic Acids Res 1992 1.17
43 Early myeloid cell-specific expression of the human cathepsin G gene in transgenic mice. Proc Natl Acad Sci U S A 1994 1.16
44 Transfusion haemosiderosis and chelation therapy. Clin Haematol 1982 1.15
45 The 5'-flanking region of the human CGL-1/granzyme B gene targets expression of a reporter gene to activated T-lymphocytes in transgenic mice. J Biol Chem 1991 1.14
46 The role of granzyme B in murine models of acute graft-versus-host disease and graft rejection. Blood 1996 1.13
47 Analysis of epitope expression and the functional repertoire of recombinant complement receptor 2 (CR2/CD21) in mouse and human cells. J Immunol 1989 1.12
48 Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2. J Biol Chem 1991 1.11
49 Hydroxyurea induction of hemoglobin F production in sickle cell disease: relationship between cytotoxicity and F cell production. Blood 1986 1.08
50 Cleavage of CPP32 by granzyme B represents a critical role for granzyme B in the induction of target cell DNA fragmentation. J Biol Chem 1996 1.07
51 Nucleotide sequence and regulation of a human 90-kDa heat shock protein gene. J Biol Chem 1989 1.06
52 Mutational profiling in the human genome. Cold Spring Harb Symp Quant Biol 2003 1.06
53 Molecular cloning, chromosomal localization, and expression of murine dipeptidyl peptidase I. J Biol Chem 1997 1.05
54 Independent formation of DnaseI hypersensitive sites in the murine beta-globin locus control region. Blood 2000 1.05
55 A human protein containing a "cold shock" domain binds specifically to H-DNA upstream from the human gamma-globin genes. J Biol Chem 1994 1.05
56 Production of fully active recombinant murine granzyme B in yeast. J Biol Chem 1998 1.02
57 The human mast cell chymase gene (CMA1): mapping to the cathepsin G/granzyme gene cluster and lineage-restricted expression. Genomics 1993 1.01
58 DNA methylation and regulation of the human beta-globin-like genes in mouse erythroleukemia cells containing human chromosome 11. Proc Natl Acad Sci U S A 1984 1.01
59 Consensus AP-1 and CRE motifs upstream from the human cytotoxic serine protease B (CSP-B/CGL-1) gene synergize to activate transcription. Blood 1993 1.00
60 Granzyme B plays a critical role in cytotoxic lymphocyte-induced apoptosis. Immunol Rev 1995 0.99
61 Stochastic, stage-specific mechanisms account for the variegation of a human globin transgene. Nucleic Acids Res 1998 0.97
62 Augmented inflammatory responses and altered wound healing in cathepsin G-deficient mice. Arch Surg 1998 0.95
63 Molecular cloning, chromosomal location, and tissue-specific expression of the murine cathepsin G gene. Blood 1993 0.95
64 Human globin gene expression in hybrid 2S MEL X human fibroblast cells. Somat Cell Mol Genet 1984 0.95
65 Mouse models of acute promyelocytic leukemia. Curr Opin Hematol 2001 0.92
66 The role of granzyme B cluster proteases in cell-mediated cytotoxicity. Semin Immunol 1997 0.91
67 Pharmacological manipulation of fetal hemoglobin synthesis in patients with severe beta-thalassemia. Ann N Y Acad Sci 1985 0.90
68 POU4F1 is associated with t(8;21) acute myeloid leukemia and contributes directly to its unique transcriptional signature. Leukemia 2010 0.90
69 Transcriptional activation of the human cytotoxic serine protease gene CSP-B in T lymphocytes. Mol Cell Biol 1990 0.90
70 A cluster of hematopoietic serine protease genes is found on the same chromosomal band as the human alpha/delta T-cell receptor locus. Proc Natl Acad Sci U S A 1990 0.90
71 Neutral proteinase expression by human mononuclear phagocytes: a prominent role of cellular differentiation. Matrix Suppl 1992 0.90
72 Disseminated infection caused by Cunninghamella bertholletiae in a patient with beta-thalassemia. Case report and review of the literature. Ann Intern Med 1985 0.89
73 Residual cytotoxicity and granzyme K expression in granzyme A-deficient cytotoxic lymphocytes. J Biol Chem 1997 0.87
74 Deletions within the mouse beta-globin locus control region preferentially reduce beta(min) globin gene expression. Genomics 2000 0.84
75 DNA methylation and globin gene expression in patients treated with 5-azacytidine. Prog Clin Biol Res 1983 0.84
76 A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes. Mol Cell Biol 1991 0.83
77 A-T-rich scaffold attachment regions flank the hematopoietic serine protease genes clustered on chromosome 14q11.2. Blood 1992 0.82
78 Acquired alpha-thalassemia in preleukemia is due to decreased expression of all four alpha-globin genes. Proc Natl Acad Sci U S A 1983 0.82
79 Induction of hemoglobin F synthesis in patients with beta thalassemia. Annu Rev Med 1985 0.82
80 Molecular mechanisms regulating the production of collagenase and TIMP in U937 cells: evidence for involvement of delayed transcriptional activation and enhanced mRNA stability. Biochemistry 1993 0.81
81 How do lymphocytes kill tumor cells? Clin Cancer Res 1996 0.81
82 High-resolution analysis of the human gamma-globin gene promoter in K562 erythroleukemia cell chromatin. Blood 1988 0.81
83 Spontaneous subarachnoid hemorrhage simulating acute transmural myocardial infarction. Am Heart J 1983 0.80
84 Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter. Oncogene 1992 0.80
85 An intramolecular DNA triplex is disrupted by point mutations associated with hereditary persistence of fetal hemoglobin. J Biol Chem 1992 0.80
86 Lack of neighborhood effects from a transcriptionally active phosphoglycerate kinase-neo cassette located between the murine beta-major and beta-minor globin genes. Blood 2001 0.79
87 Abundance and structure of globin mRNA in K562 human leukemia cells. Prog Clin Biol Res 1983 0.79
88 Mechanisms responsible for granzyme B-independent cytotoxicity. Blood 1997 0.79
89 An intramolecular triplex in the human gamma-globin 5'-flanking region is altered by point mutations associated with hereditary persistence of fetal hemoglobin. J Biol Chem 1995 0.79
90 1,25-Dihydroxyvitamin D3 induces monocytic differentiation of the PLB-985 leukemic line and promotes c-fgr mRNA expression. J Leukoc Biol 1991 0.78
91 The 5' flanking region of the human granzyme H gene directs expression to T/natural killer cell progenitors and lymphokine-activated killer cells in transgenic mice. Blood 1999 0.78
92 5-azacytidine for beta thalassaemia? Lancet 1983 0.78
93 Regulation of azurophil granule-associated serine protease genes during myelopoiesis. Curr Opin Hematol 1996 0.77
94 Globin gene expression in somatic cell hybrids. Prog Clin Biol Res 1983 0.75
95 A transient assay system to study gamma globin gene expression in K562 cells. Prog Clin Biol Res 1987 0.75
96 Induction of fgr proto-oncogene mRNA in B lymphocytes as a consequence of Epstein-Barr virus infection. Curr Top Microbiol Immunol 1986 0.75
97 Regulatory regions flanking the human fetal gamma-globin genes. Ann N Y Acad Sci 1989 0.75
98 Chelation therapy for transfusion-dependent adults. N Engl J Med 1983 0.75
99 Function of transfected globin promoters and the globin locus activator in K562 erythroleukemia cells. Ann N Y Acad Sci 1990 0.75