Will the Requirement by the US FDA to Simultaneously Co-Develop Companion Diagnostics (CDx) Delay the Approval of Receptor Tyrosine Kinase Inhibitors for RTK-Rearranged (ROS1-, RET-, AXL-, PDGFR-α-, NTRK1-) Non-Small Cell Lung Cancer Globally?

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🔗 View Article (PMC 3978317)

Published in Front Oncol on April 01, 2014

Authors

Sai-Hong Ignatius Ou1, Ross A Soo2, Akihito Kubo3, Tomoya Kawaguchi4, Myung-Ju Ahn5

Author Affiliations

1: Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine , Orange, CA , USA.
2: National University Health System and Cancer Science Institute of Singapore , Singapore.
3: Aichi Medical University School of Medicine , Nagakute , Japan.
4: National Hospital Organization Kinki-Chuo Chest Medical Center , Sakai City , Japan.
5: Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul , South Korea.

Associated clinical trials:

A Study Of Oral PF-02341066, A C-Met/Hepatocyte Growth Factor Tyrosine Kinase Inhibitor, In Patients With Advanced Cancer (PROFILE 1001) | NCT00585195

Cabozantinib in Patients With RET Fusion-Positive Advanced Non-Small Cell Lung Cancer and Those With Other Genotypes: ROS1 or NTRK Fusions or Increased MET or AXL Activity | NCT01639508

Vandetanib in Advanced NSCLC With RET Rearrangement | NCT01823068

Ponatinib in Advanced NSCLC w/ RET Translocations | NCT01813734

Study of the Safety and Activity of Lenvatinib (E7080) in Subjects With KIF5B-RET-Positive Adenocarcinoma of the Lung | NCT01877083

Sunitinib in Never-Smokers With Lung Adenocarcinoma | NCT01829217

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