Published in Nat Rev Immunol on April 22, 2014
Autologous Ex Vivo Expanded Regulatory T Cells in Ulcerative Colitis | NCT04691232
Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease. Nat Med (2017) 2.08
Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis. Cell (2015) 1.81
Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6. Nature (2015) 1.76
Granulocyte Macrophage Colony-Stimulating Factor-Activated Eosinophils Promote Interleukin-23 Driven Chronic Colitis. Immunity (2015) 1.66
Role and species-specific expression of colon T cell homing receptor GPR15 in colitis. Nat Immunol (2014) 1.58
Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease-Associated Colorectal Cancers. Gastroenterology (2016) 1.52
Maternal IgG and IgA Antibodies Dampen Mucosal T Helper Cell Responses in Early Life. Cell (2016) 1.50
Current and emerging therapeutic targets for IBD. Nat Rev Gastroenterol Hepatol (2017) 1.42
Immunopathogenesis of IBD: current state of the art. Nat Rev Gastroenterol Hepatol (2015) 1.34
Transcriptional regulation of innate lymphoid cell fate. Nat Rev Immunol (2015) 1.21
Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases. Nat Rev Rheumatol (2015) 1.11
T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4⁺ T cells. Science (2016) 1.04
Intestinal Behçet's Disease: A True Inflammatory Bowel Disease or Merely an Intestinal Complication of Systemic Vasculitis? Yonsei Med J (2016) 1.03
MicroRNAs and the regulation of intestinal homeostasis. Front Genet (2014) 0.97
Exercise and gut immune function: evidence of alterations in colon immune cell homeostasis and microbiome characteristics with exercise training. Immunol Cell Biol (2015) 0.93
Crohn's disease-derived monocytes fail to induce Paneth cell defensins. Proc Natl Acad Sci U S A (2015) 0.92
Transcriptomic landscape of lncRNAs in inflammatory bowel disease. Genome Med (2015) 0.91
Cytokines, IBD, and colitis-associated cancer. Inflamm Bowel Dis (2015) 0.91
The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway. Cell Mol Immunol (2016) 0.91
SIGNR3-dependent immune regulation by Lactobacillus acidophilus surface layer protein A in colitis. EMBO J (2015) 0.90
An evidence-based update on the pharmacological activities and possible molecular targets of Lycium barbarum polysaccharides. Drug Des Devel Ther (2014) 0.89
TGF-β converts Th1 cells into Th17 cells through stimulation of Runx1 expression. Eur J Immunol (2015) 0.89
Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biological Treatments. Mediators Inflamm (2015) 0.89
Cytokine Secretion in Macrophages: SNAREs, Rabs, and Membrane Trafficking. Front Immunol (2014) 0.88
First case report of exacerbated ulcerative colitis after anti-interleukin-6R salvage therapy. World J Gastroenterol (2015) 0.87
Beneficial Effects of Fecal Microbiota Transplantation on Ulcerative Colitis in Mice. Dig Dis Sci (2016) 0.85
The guanylate cyclase-C signaling pathway is down-regulated in inflammatory bowel disease. Scand J Gastroenterol (2015) 0.84
Th9 cells in inflammatory bowel diseases. Semin Immunopathol (2016) 0.84
The "ins and outs" of complement-driven immune responses. Immunol Rev (2016) 0.84
Cytokine-Defined B Cell Responses as Therapeutic Targets in Multiple Sclerosis. Front Immunol (2016) 0.83
S1pping fire: Sphingosine-1-phosphate signaling as an emerging target in inflammatory bowel disease and colitis-associated cancer. Clin Exp Gastroenterol (2014) 0.83
Cytokines and mucosal immunity. Curr Opin Gastroenterol (2014) 0.83
Integrative analysis of genetic data sets reveals a shared innate immune component in autism spectrum disorder and its co-morbidities. Genome Biol (2016) 0.82
Gastrointestinal stem cells in health and disease: from flies to humans. Dis Model Mech (2016) 0.82
Intestinal Epithelial Cell Tyrosine Kinase 2 Transduces IL-22 Signals To Protect from Acute Colitis. J Immunol (2015) 0.82
The multiple roles of sucrase-isomaltase in the intestinal physiology. Mol Cell Pediatr (2016) 0.82
Mechanisms Underlying Dysregulation of Electrolyte Absorption in Inflammatory Bowel Disease-Associated Diarrhea. Inflamm Bowel Dis (2015) 0.82
Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo. Gut (2015) 0.81
Sphingosine-1-phosphate phosphatase 2 promotes disruption of mucosal integrity, and contributes to ulcerative colitis in mice and humans. FASEB J (2016) 0.81
Endometrial regenerative cells as a novel cell therapy attenuate experimental colitis in mice. J Transl Med (2014) 0.81
Local chemerin levels are positively associated with DSS-induced colitis but constitutive loss of CMKLR1 does not protect against development of colitis. Physiol Rep (2015) 0.81
Corticotropin-Releasing Hormone Receptor 2 Signaling Promotes Mucosal Repair Responses after Colitis. Am J Pathol (2015) 0.80
Ethanolic Echinacea purpurea Extracts Contain a Mixture of Cytokine-Suppressive and Cytokine-Inducing Compounds, Including Some That Originate from Endophytic Bacteria. PLoS One (2015) 0.80
Fucoidan Extracts Ameliorate Acute Colitis. PLoS One (2015) 0.80
Examination of the effects of Campylobacter concisus zonula occludens toxin on intestinal epithelial cells and macrophages. Gut Pathog (2016) 0.80
Leucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response. PLoS One (2015) 0.80
Granzyme M has a critical role in providing innate immune protection in ulcerative colitis. Cell Death Dis (2016) 0.80
Role of Cannabinoids in Gastrointestinal Mucosal Defense and Inflammation. Curr Neuropharmacol (2016) 0.80
The matricellular protein CCN1 promotes mucosal healing in murine colitis through IL-6. Mucosal Immunol (2015) 0.80
Mechanisms on spasmolytic and anti-inflammatory effects of a herbal medicinal product consisting of myrrh, chamomile flower, and coffee charcoal. Wien Med Wochenschr (2017) 0.80
Strategies to direct the enrichment, expansion, and recruitment of regulatory cells for the treatment of disease. Ann Biomed Eng (2014) 0.80
Lactobacillus reuteri 6475 Increases Bone Density in Intact Females Only under an Inflammatory Setting. PLoS One (2016) 0.80
IL-1β reduces tonic contraction of mesenteric lymphatic muscle cells, with the involvement of cycloxygenase-2 and prostaglandin E2. Br J Pharmacol (2015) 0.79
The impact of ATRA on shaping human myeloid cell responses to epithelial cell-derived stimuli and on T-lymphocyte polarization. Mediators Inflamm (2015) 0.79
Inflammation and the Intestinal Barrier: Leukocyte-Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair. Gastroenterology (2016) 0.79
Death in the intestinal epithelium-basic biology and implications for inflammatory bowel disease. FEBS J (2016) 0.79
Protective effect of quercetin on pig intestinal integrity after transport stress is associated with regulation oxidative status and inflammation. J Vet Med Sci (2016) 0.79
MicroRNA-146a constrains multiple parameters of intestinal immunity and increases susceptibility to DSS colitis. Oncotarget (2015) 0.79
Altered STAT4 Isoform Expression in Patients with Inflammatory Bowel Disease. Inflamm Bowel Dis (2015) 0.79
Allicin alleviates inflammation of trinitrobenzenesulfonic acid-induced rats and suppresses P38 and JNK pathways in Caco-2 cells. Mediators Inflamm (2015) 0.79
A Novel Peroxisome Proliferator-activated Receptor (PPAR)γ Agonist 2-Hydroxyethyl 5-chloro-4,5-didehydrojasmonate Exerts Anti-Inflammatory Effects in Colitis. J Biol Chem (2015) 0.79
Fermented Herbal Formulas KIOM-MA128 Ameliorate IL-6-Induced Intestinal Barrier Dysfunction in Colon Cancer Cell Line. Mediators Inflamm (2016) 0.78
Loss of interleukin 33 expression in colonic crypts - a potential marker for disease remission in ulcerative colitis. Sci Rep (2016) 0.78
Crotoxin from Crotalus durissus terrificus is able to down-modulate the acute intestinal inflammation in mice. PLoS One (2015) 0.78
IL-15-dependent balance between Foxp3 and RORγt expression impacts inflammatory bowel disease. Nat Commun (2016) 0.78
The phosphatase DUSP2 controls the activity of the transcription activator STAT3 and regulates TH17 differentiation. Nat Immunol (2015) 0.78
Dual TNF-α/IL-12p40 Interference as a Strategy to Protect Against Colitis Based on miR-16 Precursors With Macrophage Targeting Vectors. Mol Ther (2015) 0.78
Regulation of human intestinal T-cell responses by type 1 interferon-STAT1 signaling is disrupted in inflammatory bowel disease. Mucosal Immunol (2016) 0.78
A critical role for cellular inhibitor of protein 2 (cIAP2) in colitis-associated colorectal cancer and intestinal homeostasis mediated by the inflammasome and survival pathways. Mucosal Immunol (2015) 0.78
Group X Secreted Phospholipase A2 Releases ω3 Polyunsaturated Fatty Acids, Suppresses Colitis, and Promotes Sperm Fertility. J Biol Chem (2016) 0.78
Gene expression profiling in necrotizing enterocolitis reveals pathways common to those reported in Crohn's disease. BMC Med Genomics (2016) 0.78
Tea polyphenols inhibit the activation of NF-κB and the secretion of cytokines and matrix metalloproteinases by macrophages stimulated with Fusobacterium nucleatum. Sci Rep (2016) 0.78
Microbiome-Epigenome Interactions and the Environmental Origins of Inflammatory Bowel Diseases. J Pediatr Gastroenterol Nutr (2016) 0.78
Impact of T300A Variant of ATG16L1 on Antibacterial Response, Risk of Culture Positive Infections, and Clinical Course of Crohn's Disease. Clin Transl Gastroenterol (2015) 0.78
Clinical Effects of a Topically Applied Toll-like Receptor 9 Agonist in Active Moderate-to-Severe Ulcerative Colitis. J Crohns Colitis (2016) 0.77
Plasma-induced signatures reveal an extracellular milieu possessing an immunoregulatory bias in treatment-naive paediatric inflammatory bowel disease. Clin Exp Immunol (2016) 0.77
Metformin Improves Ileal Epithelial Barrier Function in Interleukin-10 Deficient Mice. PLoS One (2016) 0.77
Oregano Essential Oil Improves Intestinal Morphology and Expression of Tight Junction Proteins Associated with Modulation of Selected Intestinal Bacteria and Immune Status in a Pig Model. Biomed Res Int (2016) 0.77
Pathophysiological role of guanylate-binding proteins in gastrointestinal diseases. World J Gastroenterol (2016) 0.77
Translational Nano-Medicines: Targeted Therapeutic Delivery for Cancer and Inflammatory Diseases. AAPS J (2015) 0.77
The Importance of Intestinal Eotaxin-1 in Inflammatory Bowel Disease: New Insights and Possible Therapeutic Implications. Dig Dis Sci (2016) 0.77
Using Computerized Physician Order Entry to Ensure Appropriate Vaccination of Patients with Inflammatory Bowel Disease. Ochsner J (2016) 0.77
Type I IFN induces protein ISGylation to enhance cytokine expression and augments colonic inflammation. Proc Natl Acad Sci U S A (2015) 0.77
Death-associated protein kinase: A molecule with functional antagonistic duality and a potential role in inflammatory bowel disease (Review). Int J Oncol (2015) 0.77
Orally Administered Enoxaparin Ameliorates Acute Colitis by Reducing Macrophage-Associated Inflammatory Responses. PLoS One (2015) 0.77
Short-Term Surveillance of Cytokines and C-Reactive Protein Cannot Predict Efficacy of Fecal Microbiota Transplantation for Ulcerative Colitis. PLoS One (2016) 0.77
Prevention of colitis-associated cancer by selective targeting of immunoproteasome subunit LMP7. Oncotarget (2017) 0.77
Cyclooxygenase-2 silencing for the treatment of colitis: a combined in vivo strategy based on RNA interference and engineered Escherichia coli. Mol Ther (2014) 0.76
T-bet expression by Th cells promotes type 1 inflammation but is dispensable for colitis. Mucosal Immunol (2016) 0.76
Role of Chlorogenic Acids in Controlling Oxidative and Inflammatory Stress Conditions. Nutrients (2015) 0.76
Neutralization of pro-inflammatory monocytes by targeting TLR2 dimerization ameliorates colitis. EMBO J (2016) 0.76
Divalent metal-ion transporter 1 is decreased in intestinal epithelial cells and contributes to the anemia in inflammatory bowel disease. Sci Rep (2015) 0.76
PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation. Biochim Biophys Acta (2015) 0.76
Human and mouse monocytes display distinct signalling and cytokine profiles upon stimulation with FFAR2/FFAR3 short-chain fatty acid receptor agonists. Sci Rep (2016) 0.76
Molecular Signaling and Dysfunction of the Human Reactive Enteric Glial Cell Phenotype: Implications for GI Infection, IBD, POI, Neurological, Motility, and GI Disorders. Inflamm Bowel Dis (2016) 0.76
Epithelial IL-1R2 acts as a homeostatic regulator during remission of ulcerative colitis. Mucosal Immunol (2015) 0.76
Vitamin A Impairs the Reprogramming of Tregs into IL-17-Producing Cells during Intestinal Inflammation. Biomed Res Int (2015) 0.76
Inflammatory Bowel Disease: Updates on Molecular Targets for Biologics. Gut Liver (2017) 0.75
Inflammatory Potential of Diet and Risk of Ulcerative Colitis in a Case-Control Study from Iran. Nutr Cancer (2016) 0.75