Published in J Cardiovasc Pharmacol on August 01, 1989
Prediction of binding constants of protein ligands: a fast method for the prioritization of hits obtained from de novo design or 3D database search programs. J Comput Aided Mol Des (1998) 1.74
Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT1-receptor subtype. Br J Pharmacol (1993) 1.02
The selectivity of statine-based inhibitors against various human aspartic proteinases. Biochem J (1990) 0.97
CGP 53437, an orally bioavailable inhibitor of human immunodeficiency virus type 1 protease with potent antiviral activity. Antimicrob Agents Chemother (1993) 0.84
Persistence of HIV-1 transcription in peripheral-blood mononuclear cells in patients receiving potent antiretroviral therapy. N Engl J Med (1999) 5.18
Rational design of peptide-based HIV proteinase inhibitors. Science (1990) 4.57
The fate of integrated treatment: whatever happened to the biopsychosocial psychiatrist? Am J Psychiatry (2001) 3.41
An economic appraisal of alternative pre-natal screening programmes for Down's syndrome. J Public Health Med (1993) 2.92
Activation of CD4 cells by fibronectin and anti-CD3 antibody. A synergistic effect mediated by the VLA-5 fibronectin receptor complex. J Exp Med (1989) 2.69
The enhancer domain of the human cytomegalovirus major immediate-early promoter determines cell type-specific expression in transgenic mice. J Virol (1996) 2.37
Blood pressure and nutrient intake in the United States. Science (1984) 2.33
The development of a tool to assess neonatal pain. Neonatal Netw (1993) 2.08
A case of factitious hypocalcaemia. Ann Clin Biochem (1998) 1.98
A receptor subtype involved in neuropeptide-Y-induced food intake. Nature (1996) 1.96
Epidemiology of headache and childhood migraine in an urban general practice using Ad Hoc, Vahlquist and IHS criteria. Dev Med Child Neurol (1992) 1.94
Aspartic proteases of Plasmodium falciparum and other parasitic protozoa as drug targets. Trends Parasitol (2001) 1.90
Preliminary biochemical characterization of two angiotensin II receptor subtypes. Biochem Biophys Res Commun (1989) 1.79
Complications associated with a narrow bore nasogastric tube. Ann Otol Rhinol Laryngol (1984) 1.62
Traumatic deidealization and the future of medicine. JAMA (1990) 1.61
The course of alcohol withdrawal in a general hospital. QJM (1997) 1.59
Zymogens of proteolytic enzymes. Science (1973) 1.51
Hemorrhagic shock and encephalopathy: clinical, pathologic, and biochemical features. J Pediatr (1989) 1.50
Synthesis and biological properties of (carboxyalkyl)amino-substituted bicyclic lactam inhibitors of angiotensin converting enzyme. J Med Chem (1985) 1.44
A prospective survey of reactions to blood tests by children and adolescents. Pain (1990) 1.42
Angiotensin II-receptor subtypes in human atria and evidence for alterations in patients with cardiac dysfunction. Eur Heart J (1996) 1.42
Modulation of the renin-angiotensin pathway through enzyme inhibition and specific receptor blockade in pacing-induced heart failure: I. Effects on left ventricular performance and neurohormonal systems. Circulation (1997) 1.42
Roles of angiotensin II type 2 receptor stimulation associated with selective angiotensin II type 1 receptor blockade with valsartan in the improvement of inflammation-induced vascular injury. Circulation (2001) 1.41
Isolation and characterization of beta-glucan receptors on human mononuclear phagocytes. J Exp Med (1991) 1.40
Near-patient testing by proxy. Ann Clin Biochem (1997) 1.39
Preparation and Use of Dried Plasma for Transfusion. Br Med J (1940) 1.38
Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin. Chem Biol (2000) 1.37
The autoactivation of trypsinogen. J Biol Chem (1971) 1.35
Different requirements for productive interaction between the active site of HIV-1 proteinase and substrates containing -hydrophobic*hydrophobic- or -aromatic*pro- cleavage sites. Biochemistry (1992) 1.33
Differences in duration of pregnancy. Negro and white women of low socioeconomic class. Arch Environ Health (1967) 1.32
Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro. J Pharmacol Exp Ther (1987) 1.31
A systematic series of synthetic chromophoric substrates for aspartic proteinases. Biochem J (1986) 1.28
Computerised decision support systems in order communication for diagnostic, screening or monitoring test ordering: systematic reviews of the effects and cost-effectiveness of systems. Health Technol Assess (2010) 1.26
Antigen processing for presentation by class II major histocompatibility complex requires cleavage by cathepsin E. Eur J Immunol (1992) 1.25
High level expression and characterisation of Plasmepsin II, an aspartic proteinase from Plasmodium falciparum. FEBS Lett (1994) 1.23
Immunolocalization of cathepsin D in normal and neoplastic human tissues. J Clin Pathol (1986) 1.22
The activation of bovine pepsinogen. Sequence of the peptides released, identification of a pepsin inhibitor. J Biol Chem (1974) 1.21
Changes in HIV-related behaviors among heterosexual alcoholics following addiction treatment. Drug Alcohol Depend (1997) 1.21
Subsite preferences of retroviral proteinases. Methods Enzymol (1994) 1.19
Expression and characterisation of plasmepsin I from Plasmodium falciparum. Eur J Biochem (1997) 1.19
Angiotensin type 2 receptor mediates valsartan-induced hypotension in conscious rats. Hypertension (2000) 1.17
Modulation of the renin-angiotensin pathway through enzyme inhibition and specific receptor blockade in pacing-induced heart failure: II. Effects on myocyte contractile processes. Circulation (1997) 1.16
Effective blocking of HIV-1 proteinase activity by characteristic inhibitors of aspartic proteinases. FEBS Lett (1989) 1.16
Presence and possible significance of immunocytochemically demonstrable metallothionein over-expression in primary invasive ductal carcinoma of the breast. Virchows Arch A Pathol Anat Histopathol (1993) 1.13
The inactivation of native enzymes by a neutral proteinase from rat intestinal muscle. Biochem J (1978) 1.11
Clinical epidemiology of childhood abdominal migraine in an urban general practice. Dev Med Child Neurol (1993) 1.08
Adding gabapentin to a multimodal regimen does not reduce acute pain, opioid consumption or chronic pain after total hip arthroplasty. Acta Anaesthesiol Scand (2009) 1.08
Food, eating habits, and health: a further examination of the relationship between food eating patterns and nutritional health. Am J Clin Nutr (1982) 1.07
An active site peptide from pepsin C. Biochem J (1971) 1.06
Sequence, expression and modeled structure of an aspartic proteinase from the human malaria parasite Plasmodium falciparum. Mol Biochem Parasitol (1994) 1.06
Fine structure of the murine leptin receptor gene: splice site suppression is required to form two alternatively spliced transcripts. Genomics (1997) 1.05
Environmental cadmium is not sequestered by metallothionein in rainbow trout. Biochem Biophys Res Commun (1983) 1.03
Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT1-receptor subtype. Br J Pharmacol (1993) 1.02
Distribution of type-1 and type-2 angiotensin receptors in the normal human lung and in lungs from patients with chronic obstructive pulmonary disease. Histochem Cell Biol (2001) 1.02
Letter-by-letter reading: psychological descriptions of a neurological syndrome. Q J Exp Psychol A (1982) 1.02
Identification of eukaryotic parvulin homologues: a new subfamily of peptidylprolyl cis-trans isomerases. Biochem Biophys Res Commun (1999) 1.01
The aspartic proteinase from Saccharomyces cerevisiae folds its own inhibitor into a helix. Nat Struct Biol (2000) 1.01
The angiotensin AT2 receptor stimulates protein tyrosine phosphatase activity and mediates inhibition of particulate guanylate cyclase. Biochem Biophys Res Commun (1992) 1.01
The prevalence of headache and migraine in atopic children: an epidemiological study in general practice. Headache (1993) 1.01
Churg-strauss syndrome with diffuse gastrointestinal involvement. J Clin Rheumatol (1996) 1.01
Structure of equine infectious anemia virus proteinase complexed with an inhibitor. Protein Sci (1996) 1.00
Effect of posture and isoproterenol on beat-to-beat heart rate and QT variability. Neuropsychobiology (2000) 1.00
The pH dependence of the hydrolysis of chromogenic substrates of the type, Lys-Pro-Xaa-Yaa-Phe-(NO2)Phe-Arg-Leu, by selected aspartic proteinases: evidence for specific interactions in subsites S3 and S2. Biochim Biophys Acta (1987) 1.00
Analysis of the alpha-synuclein G209A mutation in familial Parkinson's disease. Lancet (1998) 1.00
Agonistic and antagonistic properties of angiotensin analogs at the AT2 receptor in PC12W cells. Regul Pept (1993) 0.99
Slow moving proteinase. Isolation, characterization, and immunohistochemical localization in gastric mucosa. Gastroenterology (1987) 0.99
Effect of age on long-term heart rate variability. Cardiovasc Res (1997) 0.98
Escape mutants of HIV-1 proteinase: enzymic efficiency and susceptibility to inhibition. Biochim Biophys Acta (1997) 0.98
Consumption of sugars. Am J Clin Nutr (1995) 0.98
Hematologic and immunologic abnormalities in anorexia nervosa. South Med J (1983) 0.98
Conversion of pepsinogen into pepsin is not a one-step process. Biochem J (1976) 0.97
A consensus sequence for substrate hydrolysis by rhinovirus 3C proteinase. FEBS Lett (1989) 0.96
Angiotensin II receptor subtypes: characterization, signalling mechanisms, and possible physiological implications. Front Neuroendocrinol (1993) 0.96
The angiotensin AT2 receptor modulates T-type calcium current in non-differentiated NG108-15 cells. FEBS Lett (1992) 0.95
Childhood migraine in general practice: clinical features and characteristics. Cephalalgia (1992) 0.95
A comparison of the accumulation and protein binding of environmental cadmium in the gills, kidney and liver of rainbow trout (Salmo gairdneri Richardson). Comp Biochem Physiol C (1983) 0.95
Binding characteristics and vascular effects of various angiotensin II antagonists. J Cardiovasc Pharmacol (1990) 0.95
Hydrolysis of synthetic chromogenic substrates by HIV-1 and HIV-2 proteinases. Biochem Biophys Res Commun (1990) 0.95
Identification of the acid proteinase in human seminal fluid as a gastricsin originating in the prostate. Cell Tissue Res (1984) 0.95
Identification of the aspartic proteinases from human erythrocyte membranes and gastric mucosa (slow-moving proteinase) as catalytically equivalent to cathepsin E. Biochem J (1988) 0.95
Control of insulin secretion in the developing pancreatic rudiment. Dev Biol (1975) 0.95
Cytokines in murine lyme carditis: Th1 cytokine expression follows expression of proinflammatory cytokines in a susceptible mouse strain. J Infect Dis (1998) 0.94
Food eating patterns and health: a reexamination of the Ten-State and HANES I surveys. Am J Clin Nutr (1981) 0.94
Natural processing sites for human cathepsin E and cathepsin D in tetanus toxin: implications for T cell epitope generation. J Immunol (1997) 0.94
Angiotensin II AT2 receptors do not interact with guanine nucleotide binding proteins. Eur J Pharmacol (1991) 0.94
In vitro inhibition of HIV-1 proteinase by cerulenin. FEBS Lett (1990) 0.94
Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y5 receptor. J Clin Invest (1998) 0.93
A distinct member of the aspartic proteinase gene family from the human malaria parasite Plasmodium falciparum. FEBS Lett (1999) 0.93
Intracellular protein degradation. Biochem Soc Trans (1978) 0.93
A semicontinuous assay for glycogen phosphorylase. Anal Biochem (1978) 0.93
An assay to differentiate the "true" activity of pepsin from the potential activity of pepsinogen. Anal Biochem (1975) 0.92
beta(2)-Microglobulin modified with advanced glycation end products delays monocyte apoptosis. Kidney Int (2001) 0.92
Degradation of smooth-muscle myosin by trypsin-like serine proteinases. Biochem J (1982) 0.92
The interaction of aspartic proteinases with naturally-occurring inhibitors from actinomycetes and Ascaris lumbricoides. J Enzyme Inhib (1985) 0.92
Medical students' perceptions of patient-initiated sexual behavior. Acad Med (1994) 0.92
Uric acid levels in full-term and low-birth-weight infants. J Pediatr (1968) 0.92
Pseudologia fantastica and factitious disorder: review of the literature and a case report. Compr Psychiatry (1999) 0.92
Does a history of maternal migraine or depression predispose children to headache and stomach-ache? Headache (1992) 0.92