Published in Spine J on April 24, 2014
Blocking the function of inflammatory cytokines and mediators by using IL-10 and TGF-β: a potential biological immunotherapy for intervertebral disc degeneration in a beagle model. Int J Mol Sci (2014) 0.84
Intradiscal platelet-rich plasma (PRP) injections for discogenic low back pain: an update. Int Orthop (2016) 0.75
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27
Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim Biophys Acta (1986) 13.69
The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family. Proc Natl Acad Sci U S A (1990) 4.46
S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death. Science (2002) 4.13
Surgical versus nonoperative treatment for lumbar disc herniation: four-year results for the Spine Patient Outcomes Research Trial (SPORT). Spine (Phila Pa 1976) (2008) 3.46
Long-term outcomes of surgical and nonsurgical management of sciatica secondary to a lumbar disc herniation: 10 year results from the maine lumbar spine study. Spine (Phila Pa 1976) (2005) 3.17
A novel rabbit model of mild, reproducible disc degeneration by an anulus needle puncture: correlation between the degree of disc injury and radiological and histological appearances of disc degeneration. Spine (Phila Pa 1976) (2005) 2.87
Biology of intervertebral disc aging and degeneration: involvement of the extracellular matrix. Spine (Phila Pa 1976) (2004) 2.67
Surgical and nonsurgical management of sciatica secondary to a lumbar disc herniation: five-year outcomes from the Maine Lumbar Spine Study. Spine (Phila Pa 1976) (2001) 2.17
A slowly progressive and reproducible animal model of intervertebral disc degeneration characterized by MRI, X-ray, and histology. Spine (Phila Pa 1976) (2005) 2.14
The effect of recombinant human bone morphogenetic protein-2 in single-level posterior lumbar interbody arthrodesis. J Bone Joint Surg Am (2013) 2.13
Low back pain hospitalization. Recent United States trends and regional variations. Spine (Phila Pa 1976) (1994) 2.00
Lumbar disc excision in children and adolescents. Spine (Phila Pa 1976) (2001) 1.78
Seven- to 20-year outcome of lumbar discectomy. Spine (Phila Pa 1976) (1999) 1.76
Stimulation of mature canine intervertebral disc by growth factors. Spine (Phila Pa 1976) (1991) 1.75
Quantitative analysis of gene expression in a rabbit model of intervertebral disc degeneration by real-time polymerase chain reaction. Spine J (2005) 1.74
Osteogenic protein-1 injection into a degenerated disc induces the restoration of disc height and structural changes in the rabbit anular puncture model. Spine (Phila Pa 1976) (2006) 1.74
In vivo growth factor treatment of degenerated intervertebral discs. Spine (Phila Pa 1976) (2004) 1.71
Influence of rhBMP-2 on the healing patterns associated with allograft interbody constructs in comparison with autograft. Spine (Phila Pa 1976) (2006) 1.67
Evidence for skeletal progenitor cells in the degenerate human intervertebral disc. Spine (Phila Pa 1976) (2007) 1.60
Toward an optimum system for intervertebral disc organ culture: TGF-beta 3 enhances nucleus pulposus and anulus fibrosus survival and function through modulation of TGF-beta-R expression and ERK signaling. Spine (Phila Pa 1976) (2006) 1.30
Challenges and strategies in the repair of ruptured annulus fibrosus. Eur Cell Mater (2013) 1.27
Role of biomechanics in intervertebral disc degeneration and regenerative therapies: what needs repairing in the disc and what are promising biomaterials for its repair? Spine J (2013) 1.25
Effect of limited nutrition on in situ intervertebral disc cells under simulated-physiological loading. Spine (Phila Pa 1976) (2009) 1.23
Mechanical and pathologic consequences of induced concentric anular tears in an ovine model. Spine (Phila Pa 1976) (2001) 1.23
A role for TNFα in intervertebral disc degeneration: a non-recoverable catabolic shift. Biochem Biophys Res Commun (2013) 1.08
Molecular profiling of the developing mouse axial skeleton: a role for Tgfbr2 in the development of the intervertebral disc. BMC Dev Biol (2010) 1.07
Regenerative potential of TGFβ3 + Dex and notochordal cell conditioned media on degenerated human intervertebral disc cells. J Orthop Res (2011) 1.06
The mechanism of aggrecan release from cartilage differs with tissue origin and the agent used to stimulate catabolism. Biochem J (2002) 1.04
Intradiscal injections of osteogenic protein-1 restore the viscoelastic properties of degenerated intervertebral discs. Spine J (2006) 1.03
Treatment of lumbar disc herniation: Evidence-based practice. Int J Gen Med (2010) 1.02
Long-term back pain after a single-level discectomy for radiculopathy: incidence and health care cost analysis. J Neurosurg Spine (2010) 1.02
Growth factors and the intervertebral disc. Spine J (2004) 1.01
Cell death in intervertebral disc degeneration. Apoptosis (2013) 1.01
Molecular and genetic advances in the regeneration of the intervertebral disc. Surg Neurol Int (2013) 1.01
The development of low-back pain after excision of a lumbar disc. J Bone Joint Surg Am (1989) 0.97
MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein. Matrix Biol (2010) 0.96
Back pain in athletes. J Am Acad Orthop Surg (2006) 0.95
Spine injuries in the sport of gymnastics. Curr Sports Med Rep (2009) 0.94
Mechanical deformation and glycosaminoglycan content changes in a rabbit annular puncture disc degeneration model. Spine (Phila Pa 1976) (2011) 0.94
Accuracy of three techniques to determine cell viability in 3D tissues or scaffolds. Tissue Eng Part C Methods (2008) 0.94
Disruption of the cysteine-75 and zinc ion coordination is not sufficient to activate the precursor of human matrix metalloproteinase 3 (stromelysin 1). Biochemistry (1993) 0.94
TGF-β signaling plays an essential role in the growth and maintenance of intervertebral disc tissue. FEBS Lett (2011) 0.92
Frequency and clinical meaning of long-term degenerative changes after lumbar discectomy visualized on imaging tests. Eur Spine J (2009) 0.91
Height and torsional stiffness are most sensitive to annular injury in large animal intervertebral discs. Spine J (2012) 0.88
Low back pain in the adolescent athlete. Phys Med Rehabil Clin N Am (2008) 0.87
BMP13 prevents the effects of annular injury in an ovine model. Int J Biol Sci (2009) 0.86
Anabolic effects of Peniel 2000, a peptide that regulates TGF-β1 signaling on intervertebral disc degeneration. Spine (Phila Pa 1976) (2013) 0.85
Fusion rates in multilevel, instrumented anterior cervical fusion for degenerative disease with and without the use of bone morphogenetic protein. J Neurosurg Spine (2013) 0.82
Towards biological anulus repair: TGF-β3, FGF-2 and human serum support matrix formation by human anulus fibrosus cells. Tissue Cell (2012) 0.82
Segmental variation in the in vitro cell metabolism of nucleus pulposus cells isolated from a series of bovine caudal intervertebral discs. Spine (Phila Pa 1976) (2005) 0.81
Micromass culture of human anulus cells: morphology and extracellular matrix production. Spine (Phila Pa 1976) (2010) 0.79
Effects of TGF-beta1 and IGF-1 on proliferation of human nucleus pulposus cells in medium with different serum concentrations. J Orthop Surg Res (2006) 0.79
Endogenous TGF-β activity limits TSLP expression in the intervertebral disc tissue by suppressing NF-κB activation. J Orthop Res (2013) 0.79
Nitric oxide evoked p53-accumulation and apoptosis. Toxicol Lett (2003) 0.79
Paediatric lumbar disc herniation in the very young: a case-based update. Childs Nerv Syst (2011) 0.76