Not all acne is acne vulgaris.

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Prolonged remissions of cystic and conglobate acne with 13-cis-retinoic acid. N Engl J Med (1979) 4.87

Acne vulgaris: a disease of Western civilization. Arch Dermatol (2002) 4.10

The burden of skin diseases: 2004 a joint project of the American Academy of Dermatology Association and the Society for Investigative Dermatology. J Am Acad Dermatol (2006) 3.30

Tetracyclines: nonantibiotic properties and their clinical implications. J Am Acad Dermatol (2006) 3.02

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Milk consumption and acne in teenaged boys. J Am Acad Dermatol (2008) 2.33

New developments in our understanding of acne pathogenesis and treatment. Exp Dermatol (2009) 2.16

Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses. J Immunol (2002) 2.14

Isotretinoin use and the risk of inflammatory bowel disease: a case-control study. Am J Gastroenterol (2010) 2.10

Isotretinoin is not associated with inflammatory bowel disease: a population-based case-control study. Am J Gastroenterol (2009) 2.05

Expression and function of Toll-like receptors 2 and 4 in human keratinocytes. Int Immunol (2003) 1.99

The prevalence of acne in adults 20 years and older. J Am Acad Dermatol (2007) 1.94

Acne and sebaceous gland function. Clin Dermatol (2004) 1.87

Inflammatory events are involved in acne lesion initiation. J Invest Dermatol (2003) 1.83

A review of the European Directive for prescribing systemic isotretinoin for acne vulgaris. J Eur Acad Dermatol Venereol (2006) 1.78

Distinct strains of Propionibacterium acnes induce selective human beta-defensin-2 and interleukin-8 expression in human keratinocytes through toll-like receptors. J Invest Dermatol (2005) 1.76

The prevalence of acne vulgaris in adolescence. Br J Dermatol (1971) 1.72

Epidemiological survey of skin diseases in schoolchildren living in the Purus Valley (Acre State, Amazonia, Brazil). Dermatologica (1981) 1.65

Acne in adolescence and cause-specific mortality: lower coronary heart disease but higher prostate cancer mortality: the Glasgow Alumni Cohort Study. Am J Epidemiol (2005) 1.57

Epidemiology of acne in the general population: the risk of smoking. Br J Dermatol (2001) 1.54

Isotretinoin and acne in practice: a prospective analysis of 188 cases over 9 years. Dermatology (1993) 1.51

Genetic control of sebum excretion and acne--a twin study. Br J Dermatol (1988) 1.47

Prospective study of risk factors of relapse after treatment of acne with oral isotretinoin. Dermatology (2006) 1.44

Prevalence, severity, and severity risk factors of acne in high school pupils: a community-based study. J Invest Dermatol (2009) 1.44

European evidence-based (S3) guidelines for the treatment of acne. J Eur Acad Dermatol Venereol (2012) 1.40

What is the pathogenesis of acne? Exp Dermatol (2005) 1.40

A low-glycemic-load diet improves symptoms in acne vulgaris patients: a randomized controlled trial. Am J Clin Nutr (2007) 1.30

The influence of genetics and environmental factors in the pathogenesis of acne: a twin study of acne in women. J Invest Dermatol (2002) 1.29

Isotretinoin for acne vulgaris--10 years later: a safe and successful treatment. Br J Dermatol (1993) 1.27

A dose-response study of I3-cis-retinoic acid in acne vulgaris. Br J Dermatol (1983) 1.23

Enzymes involved in the biosynthesis of leukotriene B4 and prostaglandin E2 are active in sebaceous glands. J Mol Med (Berl) (2005) 1.23

Cutaneous expression of CRH and CRH-R. Is there a "skin stress response system?". Ann N Y Acad Sci (1999) 1.18

Reduced anxiety and depression in cystic acne patients after successful treatment with oral isotretinoin. J Am Acad Dermatol (1987) 1.18

[On the local therapy of keratosis with vitamin A acid]. Dermatologica (1962) 1.16

Prevalence of skin diseases in a cohort of 48,665 employees in Germany. Dermatology (2008) 1.13

Pro-inflammatory levels of interleukin-1 alpha-like bioactivity are present in the majority of open comedones in acne vulgaris. J Invest Dermatol (1992) 1.06

A histological and immunocytochemical study of early acne lesions. Br J Dermatol (1988) 1.05

The familial risk of adult acne: a comparison between first-degree relatives of affected and unaffected individuals. Br J Dermatol (1999) 1.04

Treatment of acne with intermittent isotretinoin. Br J Dermatol (1997) 1.03

Comedogenesis: some new aetiological, clinical and therapeutic strategies. Br J Dermatol (2000) 1.02

Adult female acne: a new paradigm. J Eur Acad Dermatol Venereol (2013) 0.99

An increased incidence of Propionibacterium acnes biofilms in acne vulgaris: a case-control study. Br J Dermatol (2012) 0.98

Prevalence of skin diseases among adolescents 12--16 years of age. Acta Derm Venereol (1980) 0.98

Can we define acne as a chronic disease? If so, how and when? Am J Clin Dermatol (2008) 0.98

Update and future of systemic acne treatment. Dermatology (2003) 0.96

Involvement of the corticotropin-releasing hormone system in the pathogenesis of acne vulgaris. Br J Dermatol (2008) 0.96

Depression and suicidal behavior in acne patients treated with isotretinoin: a systematic review. Semin Cutan Med Surg (2007) 0.95

The human skin as a hormone target and an endocrine gland. Hormones (Athens) (2006) 0.95

The androgen control of sebum production. Studies of subjects with dihydrotestosterone deficiency and complete androgen insensitivity. J Clin Endocrinol Metab (1993) 0.93

Diet in acne: further evidence for the role of nutrient signalling in acne pathogenesis. Acta Derm Venereol (2012) 0.91

Prevalence of acne vulgaris in Chinese adolescents and adults: a community-based study of 17,345 subjects in six cities. Acta Derm Venereol (2012) 0.91

Post-adolescent acne. Int J Cosmet Sci (2004) 0.90

Sebaceous gland response in man to the administration of testosterone, delta-4-androstenedione, and dehydroisoandrosterone. J Invest Dermatol (1969) 0.90

Is acne vulgaris a genuine inflammatory disease? Dermatology (2001) 0.90

Androgen excess in cystic acne. N Engl J Med (1983) 0.89

Oral retinoids in the treatment of seborrhoea and acne. Dermatology (1998) 0.88

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Isotretinoin and acne--a study of relapses. Dermatologica (1990) 0.87

Acne vulgaris in premenarchal girls. An early sign of puberty associated with rising levels of dehydroepiandrosterone. Arch Dermatol (1994) 0.86

Have oral contraceptives reduced the prevalence of acne? a population-based study of acne vulgaris, tobacco smoking and oral contraceptives. Dermatology (2002) 0.86

Isotretinoin in the treatment of acne: histologic changes, sebum production, and clinical observations. Arch Dermatol (1982) 0.86

Acne-associated syndromes: models for better understanding of acne pathogenesis. J Eur Acad Dermatol Venereol (2010) 0.85

Sebaceous glands in acne patients express high levels of neutral endopeptidase. Exp Dermatol (2002) 0.85

[Modern aspects of acne pathogenesis]. J Dtsch Dermatol Ges (2010) 0.85

Severe acne vulgaris and tobacco smoking in young men. J Invest Dermatol (2006) 0.84

Isotretinoin therapy in acne vulgaris: a 10-year retrospective study in Singapore. Int J Dermatol (1994) 0.83

[S2k-guideline for therapy of acne]. J Dtsch Dermatol Ges (2010) 0.83

Digital image analysis of the effect of topically applied linoleic acid on acne microcomedones. Clin Exp Dermatol (1998) 0.82

Acne and smoking: is there a relationship? BMC Dermatol (2005) 0.81

Pattern of tissue invasion by Propionibacterium acnes in acne vulgaris. J Dermatol Sci (2012) 0.81

[Specificity of acne in women older than 25 years]. Presse Med (2008) 0.80

Expression of sex-determining genes in human sebaceous glands and their possible role in the pathogenesis of acne. J Eur Acad Dermatol Venereol (2006) 0.80

Isotretinoin--an explanation for its long-term benefit. Dermatologica (1987) 0.79

Effects of isotretinoin treatment on general psychiatric symptoms, quality of life and social phobia in acne vulgaris patients. J Eur Acad Dermatol Venereol (2012) 0.79

13-cis-retinoic acid in conglobate acne. A follow-up study of 14 trial centers. Arch Dermatol Res (1984) 0.78

Expression pattern of cyclooxygenase-2 in normal rat epidermis and pilosebaceous unit during hair cycle. Acta Histochem Cytochem (2008) 0.78

The relapses of cystic acne after isotretinoin treatment are age-related: a long-term follow-up study. Dermatologica (1986) 0.78

[Acne vulgaris. The role of hormones]. Hautarzt (2010) 0.78

[Pharmacoeconomy in acne--evaluation of benefit and economics]. J Dtsch Dermatol Ges (2010) 0.78

[Therapy of acne scars]. J Dtsch Dermatol Ges (2010) 0.78

The truth behind this undeniable efficacy--recurrence rates and relapse risk factors of acne treatment with oral isotretinoin. Dermatology (2006) 0.78

Predictive factors for failure of isotretinoin treatment in acne patients: results from a cohort of 237 patients. Dermatology (1999) 0.78

[Systemic antibiotic therapy of acne vulgaris]. J Dtsch Dermatol Ges (2010) 0.77

Sebaceous gland activity and serum dehydroepiandrosterone sulfate levels in boys and girls. Arch Dermatol (1992) 0.77

[Acne vulgaris--psychosomatic aspects]. J Dtsch Dermatol Ges (2010) 0.77

Quality of medical care of patients with acne vulgaris in Germany--nationwide survey of pharmacy clients. J Dtsch Dermatol Ges (2009) 0.77

[Antibiotics, azelaic acid and benzoyl peroxide in topical acne therapy]. J Dtsch Dermatol Ges (2010) 0.76

[Adjunctive acne therapies--2010]. J Dtsch Dermatol Ges (2010) 0.76

[Adjuvant dermato-cosmetic acne therapy]. J Dtsch Dermatol Ges (2010) 0.76

Neuroimmunoregulation of androgens in the adrenal gland and the skin. Horm Res (2000) 0.76

[Topical retinoids in acne--an evidence-based overview]. J Dtsch Dermatol Ges (2010) 0.76

[Hormonal antiandrogens in acne treatment]. J Dtsch Dermatol Ges (2010) 0.76

[Epidemiology of acne]. J Dtsch Dermatol Ges (2010) 0.75

Adalimumab for the treatment of moderate to severe Hidradenitis suppurativa: a parallel randomized trial. Ann Intern Med (2012) 3.14

New developments in our understanding of acne pathogenesis and treatment. Exp Dermatol (2009) 2.16

Propionibacterium acnes and lipopolysaccharide induce the expression of antimicrobial peptides and proinflammatory cytokines/chemokines in human sebocytes. Microbes Infect (2006) 1.91

The treatment of chronic recurrent oral aphthous ulcers. Dtsch Arztebl Int (2014) 1.86

Steroidogenesis in the skin: implications for local immune functions. J Steroid Biochem Mol Biol (2013) 1.71

A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria. Infect Immun (2005) 1.55

Prevalence, severity, and severity risk factors of acne in high school pupils: a community-based study. J Invest Dermatol (2009) 1.44

Human sebaceous tumors harbor inactivating mutations in LEF1. Nat Med (2006) 1.40

Antimicrobial property of lauric acid against Propionibacterium acnes: its therapeutic potential for inflammatory acne vulgaris. J Invest Dermatol (2009) 1.35

Oral alitretinoin (9-cis-retinoic acid) therapy for chronic hand dermatitis in patients refractory to standard therapy: results of a randomized, double-blind, placebo-controlled, multicenter trial. Arch Dermatol (2004) 1.33

Malignant atrophic papulosis (Köhlmeier-Degos disease) - a review. Orphanet J Rare Dis (2013) 1.25

Sebum free fatty acids enhance the innate immune defense of human sebocytes by upregulating beta-defensin-2 expression. J Invest Dermatol (2009) 1.23

Enzymes involved in the biosynthesis of leukotriene B4 and prostaglandin E2 are active in sebaceous glands. J Mol Med (Berl) (2005) 1.23

Characterization of bipotential epidermal progenitors derived from human sebaceous gland: contrasting roles of c-Myc and beta-catenin. Stem Cells (2008) 1.22

13-cis retinoic acid inhibits development and progression of chronic allograft nephropathy. Am J Pathol (2005) 1.17

Peroxidated squalene induces the production of inflammatory mediators in HaCaT keratinocytes: a possible role in acne vulgaris. J Invest Dermatol (2006) 1.17

Intralesional Cryotherapy for the Treatment of Keloid Scars: A Prospective Study. Plast Reconstr Surg (2015) 1.10

Characterization of the vitamin D endocrine system in human sebocytes in vitro. J Steroid Biochem Mol Biol (2008) 1.08

Comorbidities of hidradenitis suppurativa (acne inversa). Dermatoendocrinol (2010) 1.07

Sebocytes express functional cathelicidin antimicrobial peptides and can act to kill propionibacterium acnes. J Invest Dermatol (2008) 1.06

Matrix metalloproteinases of epithelial origin in facial sebum of patients with acne and their regulation by isotretinoin. J Invest Dermatol (2005) 1.05

Cutaneous androgen metabolism: basic research and clinical perspectives. J Invest Dermatol (2002) 1.05

Skin anti-aging strategies. Dermatoendocrinol (2012) 1.05

Vaccination targeting a surface sialidase of P. acnes: implication for new treatment of acne vulgaris. PLoS One (2008) 1.04

Expression of lipogenic factors galectin-12, resistin, SREBP-1, and SCD in human sebaceous glands and cultured sebocytes. J Invest Dermatol (2007) 1.04

Mitochondrial-associated cell death mechanisms are reset to an embryonic-like state in aged donor-derived iPS cells harboring chromosomal aberrations. PLoS One (2011) 1.04

[Epidemiology and clinical manifestations of Adamantiades-Behçet disease in Germany -- current pathogenetic concepts and therapeutic possibilities]. J Dtsch Dermatol Ges (2006) 1.02

The skin as a mirror of the aging process in the human organism--state of the art and results of the aging research in the German National Genome Research Network 2 (NGFN-2). Exp Gerontol (2007) 1.01

Age-specific hormonal decline is accompanied by transcriptional changes in human sebocytes in vitro. Aging Cell (2006) 1.01

Identification of platelet-activating factor acetylhydrolase II in human skin. J Invest Dermatol (2002) 1.01

Bioengineering a humanized acne microenvironment model: proteomics analysis of host responses to Propionibacterium acnes infection in vivo. Proteomics (2008) 1.01

Differentiation and apoptosis in human immortalized sebocytes. J Invest Dermatol (2003) 1.00

Atypical fibroxanthoma-a diagnosis of exclusion! Wien Med Wochenschr (2013) 1.00

Transient receptor potential vanilloid-1 signaling as a regulator of human sebocyte biology. J Invest Dermatol (2008) 0.99

Involvement of PPARgamma in oxidative stress-mediated prostaglandin E(2) production in SZ95 human sebaceous gland cells. J Invest Dermatol (2006) 0.98

Follicular drug eruption induced by gefitinib (ZD 1839, iressa): clinical picture correlates with in vitro data of focal epidermal necrosis after epidermal growth factor inhibition in skin cultures. Dermatology (2005) 0.98

Evidence for expression of melanocortin-1 receptor in human sebocytes in vitro and in situ. J Invest Dermatol (2002) 0.97

A practical guide for the study of human and murine sebaceous glands in situ. Exp Dermatol (2013) 0.97

Skin and brain age together: The role of hormones in the ageing process. Exp Gerontol (2010) 0.97

Clinical, histological and demographic predictors for recurrence and second primary tumours of head and neck basal cell carcinoma. A 1062 patient-cohort study from a tertiary cancer referral hospital. Eur J Dermatol (2010) 0.95

Potential role of FoxO1 and mTORC1 in the pathogenesis of Western diet-induced acne. Exp Dermatol (2013) 0.95

Sebaceous glands as the primary target of EGFR-inhibitors in the development of papulopustular eruption. J Dermatol Sci (2012) 0.94

BP230- and BP180-specific auto-antibodies in bullous pemphigoid. J Invest Dermatol (2004) 0.94

Reactive hyperplasias,precancerous and malignant lesions of the oral mucosa. J Dtsch Dermatol Ges (2008) 0.93

Treating acne with antibiotic-resistant bacterial colonization. Expert Opin Pharmacother (2011) 0.93

Underestimated clinical features of postadolescent acne. J Am Acad Dermatol (2010) 0.92

Longterm visual prognosis of patients with ocular Adamantiades-Behçet's disease treated with interferon-alpha-2a. J Rheumatol (2008) 0.91

Anti-acne agents attenuate FGFR2 signal transduction in acne. J Invest Dermatol (2009) 0.91

Genomic gain of 5p15 leads to over-expression of Misu (NSUN2) in breast cancer. Cancer Lett (2009) 0.91

Investigation of micronized titanium dioxide penetration in human skin xenografts and its effect on cellular functions of human skin-derived cells. Exp Dermatol (2008) 0.91

Differential regulation of Toll-like receptor and CD14 pathways by retinoids and corticosteroids in human sebocytes. Dermatology (2006) 0.90

Endocannabinoids enhance lipid synthesis and apoptosis of human sebocytes via cannabinoid receptor-2-mediated signaling. FASEB J (2008) 0.90

Identification of biomarkers of human skin ageing in both genders. Wnt signalling - a label of skin ageing? PLoS One (2012) 0.90

William J. Cunliffe Scientific Awards. Characteristics and pathomechanisms of endogenously aged skin. Dermatology (2007) 0.90

Azelaic acid modulates the inflammatory response in normal human keratinocytes through PPARgamma activation. Exp Dermatol (2010) 0.90

PGD2 induces eotaxin-3 via PPARγ from sebocytes: a possible pathogenesis of eosinophilic pustular folliculitis. J Allergy Clin Immunol (2011) 0.89

A new concept for acne therapy: a pilot study with zileuton, an oral 5-lipoxygenase inhibitor. Arch Dermatol (2003) 0.89

Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer's disease donor as a model for investigating AD-associated gene regulatory networks. BMC Genomics (2015) 0.89

Zileuton, a new efficient and safe systemic anti-acne drug. Dermatoendocrinol (2009) 0.88

Androgens and ageing of the skin. Curr Opin Endocrinol Diabetes Obes (2009) 0.88

HAN11 binds mDia1 and controls GLI1 transcriptional activity. J Dermatol Sci (2006) 0.88

Intralesional cryosurgery enhances the involution of recalcitrant auricular keloids: a new clinical approach supported by experimental studies. Wound Repair Regen (2006) 0.88

Skin aging and sex hormones in women -- clinical perspectives for intervention by hormone replacement therapy. Exp Dermatol (2004) 0.87

TNF-α increases lipogenesis via JNK and PI3K/Akt pathways in SZ95 human sebocytes. J Dermatol Sci (2011) 0.87

Characterization of liver X receptor expression and function in human skin and the pilosebaceous unit. Exp Dermatol (2007) 0.87

Targeting of sebocytes by aminolevulinic acid-dependent photosensitization. Photochem Photobiol (2006) 0.86

Expression of peroxisome proliferator-activated receptor and CCAAT/enhancer binding protein transcription factors in cultured human sebocytes. J Invest Dermatol (2003) 0.86

Doxorubicin-induced alopecia is associated with sebaceous gland degeneration. J Invest Dermatol (2006) 0.85

Sebaceous gland in human skin--the fantastic future of a skin appendage. J Invest Dermatol (2003) 0.85

Nicotine and biochanin A, but not cigarette smoke, induce anti-inflammatory effects on keratinocytes and endothelial cells in patients with Behçet's disease. J Invest Dermatol (2006) 0.84

The role of neuropeptides in the multifactorial pathogenesis of acne vulgaris. Dermatoendocrinol (2009) 0.84

Association of ustekinumab and briakinumab with major adverse cardiovascular events: An appraisal of meta-analyses and industry sponsored pooled analyses to date. Dermatoendocrinol (2012) 0.84

Cyproterone acetate loading to lipid nanoparticles for topical acne treatment: particle characterisation and skin uptake. Pharm Res (2007) 0.83

Higher levels of steroidogenic acute regulatory protein and type I 3beta-hydroxysteroid dehydrogenase in the scalp of men with androgenetic alopecia. J Invest Dermatol (2006) 0.83

KdPT, a tripeptide derivative of alpha-melanocyte-stimulating hormone, suppresses IL-1 beta-mediated cytokine expression and signaling in human sebocytes. J Immunol (2010) 0.83

Sebaceous gland receptors. Dermatoendocrinol (2009) 0.83

Alteration in N-glycomics during mouse aging: a role for FUT8. Aging Cell (2011) 0.83

[S2k-guideline for therapy of acne]. J Dtsch Dermatol Ges (2010) 0.83

Three-dimensional culture of sebaceous gland cells revealing the role of prostaglandin E2-induced activation of canonical Wnt signaling. Biochem Biophys Res Commun (2013) 0.82

Emerging concepts about prenatal genesis, aberrant metabolism and treatment paradigms in polycystic ovary syndrome. Endocrine (2012) 0.82

Acrodermatitis enteropathica: an uncommon differential diagnosis in childhood - first description of a new sequence variant. J Dtsch Dermatol Ges (2011) 0.82

Inhibitors of dipeptidyl peptidase IV and aminopeptidase N target major pathogenetic steps in acne initiation. J Invest Dermatol (2006) 0.82

Cytotoxicity of multi-walled carbon nanotubes in three skin cellular models: effects of sonication, dispersive agents and corneous layer of reconstructed epidermis. Nanotoxicology (2010) 0.81

Activation of platelet-activating factor receptor in SZ95 sebocytes results in inflammatory cytokine and prostaglandin E2 production. Exp Dermatol (2006) 0.81

Biosynthesis of dihydrotestosterone by a pathway that does not require testosterone as an intermediate in the SZ95 sebaceous gland cell line. J Invest Dermatol (2009) 0.81

New pharmaceutical concepts for sebaceous gland diseases: implementing today's pre-clinical data into tomorrow's daily clinical practice. Curr Pharm Biotechnol (2012) 0.81

The skin as an endocrine organ. Dermatoendocrinol (2009) 0.81

Hormones and the pilosebaceous unit. Dermatoendocrinol (2009) 0.81

The renal retinoid system: time-dependent activation in experimental glomerulonephritis. Am J Physiol Renal Physiol (2003) 0.81

Chronic low-dose isotretinoin treatment limits renal damage in subtotally nephrectomized rats. J Mol Med (Berl) (2008) 0.81

Protein kinase C isoforms have differential roles in the regulation of human sebocyte biology. J Invest Dermatol (2012) 0.80

LXRalpha enhances lipid synthesis in SZ95 sebocytes. J Invest Dermatol (2007) 0.80

Intralesional cryosurgery for the treatment of hypertrophic scars and keloids. Plast Reconstr Surg (2010) 0.80

Ocular involvement in Adamantiades-Behçet's disease in Berlin, Germany. Graefes Arch Clin Exp Ophthalmol (2008) 0.79

Psychophysiological reactivity under mental stress in atopic dermatitis. Dermatology (2005) 0.79

2,3,7,8-Tetrachlorodibenzo-p-dioxin alters sebaceous gland cell differentiation in vitro. Exp Dermatol (2011) 0.79

Interferon alfa-2a in the treatment of ocular Adamantiades-Behçet's disease. Adv Exp Med Biol (2003) 0.79

Increased in situ expression of melanocortin-1 receptor in sebaceous glands of lesional skin of patients with acne vulgaris. Exp Dermatol (2007) 0.79

Topical retinoids in acne--an evidence-based overview. J Dtsch Dermatol Ges (2008) 0.79

Interplay of IGF-I and 17beta-estradiol at age-specific levels in human sebocytes and fibroblasts in vitro. Exp Gerontol (2008) 0.79