MUTYH the base excision repair gene family member associated with colorectal cancer polyposis.

PubWeight™: 0.75‹?›

🔗 View Article (PMC 4017534)

Published in Gastroenterol Hepatol Bed Bench on January 01, 2013

Authors

Seyed Mohammad Hossein Kashfi1, Mina Golmohammadi1, Faeghe Behboudi1, Ehsan Nazemalhosseini-Mojarad2, Mohammad Reza Zali2

Author Affiliations

1: Basic and molecular epidemiology of Gastroenterology disorders Research center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2: Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran.

Articles citing this

Tumor suppressor genes in familial adenomatous polyposis. Gastroenterol Hepatol Bed Bench (2017) 0.75

Articles cited by this

Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol (2002) 14.75

Systematic review of microsatellite instability and colorectal cancer prognosis. J Clin Oncol (2005) 8.15

Inherited variants of MYH associated with somatic G:C-->T:A mutations in colorectal tumors. Nat Genet (2002) 7.00

Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH. N Engl J Med (2003) 4.88

The mutY gene: a mutator locus in Escherichia coli that generates G.C----T.A transversions. Proc Natl Acad Sci U S A (1988) 4.36

Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents. Nucleic Acids Res (1984) 4.15

Alkylation damage in DNA and RNA--repair mechanisms and medical significance. DNA Repair (Amst) (2004) 4.03

Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome. Biochemistry (1990) 3.94

Alleles of the APC gene: an attenuated form of familial polyposis. Cell (1993) 3.84

Tumor-infiltrating lymphocytes are a marker for microsatellite instability in colorectal carcinoma. Cancer (2001) 2.82

Association between biallelic and monoallelic germline MYH gene mutations and colorectal cancer risk. J Natl Cancer Inst (2004) 2.68

DNA repair in mammalian cells: Base excision repair: the long and short of it. Cell Mol Life Sci (2009) 2.58

Site-specific mutagenesis using a gapped duplex vector: a study of translesion synthesis past 8-oxodeoxyguanosine in E. coli. Mutat Res (1991) 2.54

Biallelic germline mutations in MYH predispose to multiple colorectal adenoma and somatic G:C-->T:A mutations. Hum Mol Genet (2002) 2.48

Expanded extracolonic tumor spectrum in MUTYH-associated polyposis. Gastroenterology (2009) 2.42

Duodenal adenomatosis in familial adenomatous polyposis. Gut (2004) 2.38

The HLA system. First of two parts. N Engl J Med (2000) 2.33

Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damage. J Bacteriol (1996) 2.26

Familial adenomatous polyposis. Orphanet J Rare Dis (2009) 2.21

Germline susceptibility to colorectal cancer due to base-excision repair gene defects. Am J Hum Genet (2005) 2.17

Microsatellite instability and high content of activated cytotoxic lymphocytes identify colon cancer patients with a favorable prognosis. Am J Pathol (2001) 2.13

Base excision repair in yeast and mammals. Mutat Res (2000) 1.99

Duodenal cancer in patients with familial adenomatous polyposis (FAP): results of a 10 year prospective study. Gut (2002) 1.81

Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repair. J Biol Chem (2000) 1.69

Germline MutY human homologue mutations and colorectal cancer: a multisite case-control study. Gastroenterology (2008) 1.69

Can APC mutation analysis contribute to therapeutic decisions in familial adenomatous polyposis? Experience from 680 FAP families. Gut (2001) 1.63

Functional expression of hMYH, a human homolog of the Escherichia coli MutY protein. J Bacteriol (1999) 1.62

Human MutY homolog, a DNA glycosylase involved in base excision repair, physically and functionally interacts with mismatch repair proteins human MutS homolog 2/human MutS homolog 6. J Biol Chem (2002) 1.60

MUTYH-associated polyposis: 70 of 71 patients with biallelic mutations present with an attenuated or atypical phenotype. Int J Cancer (2006) 1.46

MUTYH-associated polyposis--from defect in base excision repair to clinical genetic testing. DNA Repair (Amst) (2006) 1.45

The C-terminal domain of the adenine-DNA glycosylase MutY confers specificity for 8-oxoguanine.adenine mispairs and may have evolved from MutT, an 8-oxo-dGTPase. Biochemistry (1999) 1.45

Prevalence of the Y165C, G382D and 1395delGGA germline mutations of the MYH gene in Italian patients with adenomatous polyposis coli and colorectal adenomas. Int J Cancer (2004) 1.42

Carcinogenesis in MYH-associated polyposis follows a distinct genetic pathway. Cancer Res (2003) 1.40

Clinical implications of the colorectal cancer risk associated with MUTYH mutation. J Clin Oncol (2009) 1.39

Base excision repair in a network of defence and tolerance. Carcinogenesis (2001) 1.39

Identification of MYH mutation carriers in colorectal cancer: a multicenter, case-control, population-based study. Clin Gastroenterol Hepatol (2007) 1.38

Multiplicity in polyp count and extracolonic manifestations in 40 Dutch patients with MYH associated polyposis coli (MAP). J Med Genet (2005) 1.38

Genetic variation in the base excision repair pathway and bladder cancer risk. Hum Genet (2007) 1.33

The selection of tumor variants with altered expression of classical and nonclassical MHC class I molecules: implications for tumor immune escape. Cancer Immunol Immunother (2004) 1.31

Physical and functional interactions between MutY glycosylase homologue (MYH) and checkpoint proteins Rad9-Rad1-Hus1. Biochem J (2006) 1.30

Leiden Open Variation Database of the MUTYH gene. Hum Mutat (2010) 1.28

Immunoselective pressure and human leukocyte antigen class I antigen machinery defects in microsatellite unstable colorectal cancers. Cancer Res (2005) 1.25

An 8-oxo-guanine repair pathway coordinated by MUTYH glycosylase and DNA polymerase lambda. Proc Natl Acad Sci U S A (2009) 1.23

Oxidative damage to purines in DNA: role of mammalian Ogg1. DNA Repair (Amst) (2006) 1.23

Genetic testing and phenotype in a large kindred with attenuated familial adenomatous polyposis. Gastroenterology (2004) 1.22

Increased colorectal cancer incidence in obligate carriers of heterozygous mutations in MUTYH. Gastroenterology (2009) 1.21

The checkpoint clamp, Rad9-Rad1-Hus1 complex, preferentially stimulates the activity of apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta in long patch base excision repair. Nucleic Acids Res (2007) 1.16

The OGG1 gene encodes a repair enzyme for oxidatively damaged DNA and is involved in human carcinogenesis. Antioxid Redox Signal (2001) 1.15

Exposing the MYtH about base excision repair and human inherited disease. Hum Mol Genet (2003) 1.14

Germline MUTYH (MYH) mutations in Portuguese individuals with multiple colorectal adenomas. Hum Mutat (2004) 1.14

A large-scale meta-analysis to refine colorectal cancer risk estimates associated with MUTYH variants. Br J Cancer (2010) 1.11

Cancer risks for monoallelic MUTYH mutation carriers with a family history of colorectal cancer. Int J Cancer (2011) 1.10

APC mutations in familial adenomatous polyposis families in the Northwest of England. Hum Mutat (1997) 1.10

MUTYH-associated polyposis (MAP). Crit Rev Oncol Hematol (2010) 1.09

Germline mutations but not somatic changes at the MYH locus contribute to the pathogenesis of unselected colorectal cancers. Am J Pathol (2003) 1.08

Association between genetic variants in the base excision repair pathway and outcomes after hematopoietic cell transplantations. Biol Blood Marrow Transplant (2010) 1.06

MUTYH Associated Polyposis (MAP). Curr Genomics (2008) 1.06

Germline mutations and polymorphic variants in MMR, E-cadherin and MYH genes associated with familial gastric cancer in Jiangsu of China. Int J Cancer (2006) 1.05

Adenine excisional repair function of MYH protein on the adenine:8-hydroxyguanine base pair in double-stranded DNA. Nucleic Acids Res (2000) 1.04

HNPCC versus sporadic microsatellite-unstable colon cancers follow different routes toward loss of HLA class I expression. BMC Cancer (2007) 1.04

Mutations of the MYH gene do not substantially contribute to the risk of breast cancer. Breast Cancer Res Treat (2008) 1.02

Identification of patients with (atypical) MUTYH-associated polyposis by KRAS2 c.34G > T prescreening followed by MUTYH hotspot analysis in formalin-fixed paraffin-embedded tissue. Clin Cancer Res (2008) 1.01

MSH6 and MUTYH deficiency is a frequent event in early-onset colorectal cancer. Clin Cancer Res (2010) 1.01

Differential DNA recognition and glycosylase activity of the native human MutY homolog (hMYH) and recombinant hMYH expressed in bacteria. Nucleic Acids Res (2001) 1.00

MYH biallelic mutation can inactivate the two genetic pathways of colorectal cancer by APC or MLH1 transversions. Fam Cancer (2010) 1.00

MUTYH Gln324His gene polymorphism and genetic susceptibility for lung cancer in a Japanese population. J Exp Clin Cancer Res (2009) 0.98

Association between monoallelic MUTYH mutation and colorectal cancer risk: a meta-regression analysis. Fam Cancer (2011) 0.97

p73 protein regulates DNA damage repair. FASEB J (2011) 0.96

Colorectal carcinomas in MUTYH-associated polyposis display histopathological similarities to microsatellite unstable carcinomas. BMC Cancer (2009) 0.94

Pathological features of colorectal carcinomas in MYH-associated polyposis. Histopathology (2008) 0.94

Colorectal cancer screening: Time for action in Iran. World J Gastrointest Oncol (2012) 0.94

High frequency of copy-neutral LOH in MUTYH-associated polyposis carcinomas. J Pathol (2008) 0.92

Germline mutation prevalence in the base excision repair gene, MYH, in patients with endometrial cancer. Clin Genet (2007) 0.91

Evaluation of 1p losses in primary carcinomas, local recurrences and peripheral metastases from colorectal cancer patients. Neoplasia (2001) 0.89

Four novel germline mutations in the MLH1 and PMS2 mismatch repair genes in patients with hereditary nonpolyposis colorectal cancer. Int J Colorectal Dis (2009) 0.89

LOH and copy neutral LOH (cnLOH) act as alternative mechanism in sporadic colorectal cancers with chromosomal and microsatellite instability. Carcinogenesis (2011) 0.88

Increased MUTYH mutation frequency among Dutch families with breast cancer and colorectal cancer. Breast Cancer Res Treat (2010) 0.88

The value of MUTYH testing in patients with early onset microsatellite stable colorectal cancer referred for hereditary nonpolyposis colon cancer syndrome testing. Genet Test (2007) 0.88

Molecular genetic analysis of 103 sporadic colorectal tumours in Czech patients. PLoS One (2011) 0.87

Similar colorectal cancer risk in patients with monoallelic and biallelic mutations in the MYH gene identified in a population with adenomatous polyposis. Genet Test (2007) 0.87

MUTYH gene variants and breast cancer in a Dutch case–control study. Breast Cancer Res Treat (2012) 0.85

Breakpoint characterization of a novel large intragenic deletion of MUTYH detected in a MAP patient: case report. BMC Med Genet (2011) 0.85

Clinical and pathological characteristics of colorectal polyps in Iranian population. East Afr J Public Health (2010) 0.84

A haplotype variation affecting the mitochondrial transportation of hMYH protein could be a risk factor for colorectal cancer in Chinese. BMC Cancer (2008) 0.84

First large rearrangement in the MUTYH gene and attenuated familial adenomatous polyposis syndrome. Clin Genet (2011) 0.83

Analysis of inherited MYH/(MutYH) mutations in British Asian patients with colorectal cancer. Gut (2007) 0.82

AluYb8 insertion in the MUTYH gene is related to increased 8-OHdG in genomic DNA and could be a risk factor for type 2 diabetes in a Chinese population. Mol Cell Endocrinol (2010) 0.81

AluYb8 insertion in the MUTYH gene and risk of early-onset breast and gastric cancers in the Chinese population. Asian Pac J Cancer Prev (2011) 0.81

Microsatellite stable colorectal cancers in clinically suspected hereditary nonpolyposis colorectal cancer patients without vertical transmission of disease are unlikely to be caused by biallelic germline mutations in MYH. J Mol Diagn (2006) 0.81

Genetic variants in MUTYH are not associated with endometrial cancer risk. Hered Cancer Clin Pract (2009) 0.79

Role of the microenvironment in the tumourigenesis of microsatellite unstable and MUTYH-associated polyposis colorectal cancers. Mutagenesis (2012) 0.78

Somatic mutation of MutYH in Tunisian patients with sporadic colorectal cancer. J Clin Lab Anal (2007) 0.77

Two novel mutations in hMLH1 gene in Iranian hereditary non-polyposis colorectal cancer patients. Fam Cancer (2012) 0.75