Published in ACS Chem Biol on May 28, 2014
Structure based approaches for targeting non-coding RNAs with small molecules. Curr Opin Struct Biol (2015) 0.79
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Combined Use of Oligopeptides, Fragment Libraries, and Natural Compounds: A Comprehensive Approach To Sample the Druggability of Vascular Endothelial Growth Factor. ChemMedChem (2015) 0.75
The Emerging Role of RNA as a Therapeutic Target for Small Molecules. Cell Chem Biol (2016) 0.75
(19)F-labeling of the adenine H2-site to study large RNAs by NMR spectroscopy. J Biomol NMR (2015) 0.75
Evolution of genes and genomes on the Drosophila phylogeny. Nature (2007) 18.01
Meat, fish, and colorectal cancer risk: the European Prospective Investigation into cancer and nutrition. J Natl Cancer Inst (2005) 4.45
A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations. Nat Struct Mol Biol (2011) 3.10
Sequence finishing and mapping of Drosophila melanogaster heterochromatin. Science (2007) 2.97
N-acetyltransferase 2 phenotype, occupation, and bladder cancer risk: results from the EPIC cohort. Cancer Epidemiol Biomarkers Prev (2013) 2.01
Perspectives on NMR in drug discovery: a technique comes of age. Nat Rev Drug Discov (2008) 1.95
An ultraviolet fluorescence-based method for identifying and distinguishing protein crystals. Acta Crystallogr D Biol Crystallogr (2004) 1.66
Sexual behaviour, history of sexually transmitted diseases, and the risk of prostate cancer: a case-control study in Cuba. Int J Epidemiol (2004) 1.66
Central wedge nymphectomy with a 90-degree Z-plasty for aesthetic reduction of the labia minora. Plast Reconstr Surg (2004) 1.65
TAHRE, a novel telomeric retrotransposon from Drosophila melanogaster, reveals the origin of Drosophila telomeres. Mol Biol Evol (2004) 1.45
Dopamine mobilizes mesenchymal progenitor cells through D2-class receptors and their PI3K/AKT pathway. Stem Cells (2014) 1.41
Genomic analysis of Drosophila melanogaster telomeres: full-length copies of HeT-A and TART elements at telomeres. Mol Biol Evol (2004) 1.36
Peptide AS-48: prototype of a new class of cyclic bacteriocins. Curr Protein Pept Sci (2004) 1.29
Structural basis for the aminoacid composition of proteins from halophilic archea. PLoS Biol (2009) 1.27
Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening. Proteins (2006) 1.15
X-ray and NMR studies of the DNA oligomer d(ATATAT): Hoogsteen base pairing in duplex DNA. Biochemistry (2004) 1.05
Chemical interrogation of FOXO3a nuclear translocation identifies potent and selective inhibitors of phosphoinositide 3-kinases. J Biol Chem (2009) 1.03
A heterogeneous wireless identification network for the localization of animals based on stochastic movements. Sensors (Basel) (2009) 1.02
Solution structure, divalent metal and DNA binding of the endonuclease domain from the replication initiation protein from porcine circovirus 2. J Mol Biol (2007) 1.02
Design and NMR-based screening of LEF, a library of chemical fragments with different local environment of fluorine. J Am Chem Soc (2009) 1.01
Transcription of the 1.688 satellite DNA family is under the control of RNA interference machinery in Drosophila melanogaster ovaries. Genetics (2007) 1.01
ICAM-1 peptide inhibitors of T-cell adhesion bind to the allosteric site of LFA-1. An NMR characterization. Chem Biol Drug Des (2007) 1.01
Ca(2+)-activated K+ channel inhibition by reactive oxygen species. Am J Physiol Cell Physiol (2002) 0.99
Hoogsteen-based parallel-stranded duplexes of DNA. Effect of 8-amino-purine derivatives. J Am Chem Soc (2002) 0.99
Novel sequencing strategy for repetitive DNA in a Drosophila BAC clone reveals that the centromeric region of the Y chromosome evolved from a telomere. Nucleic Acids Res (2009) 0.98
Structural basis for operator and antirepressor recognition by Myxococcus xanthus CarA repressor. Mol Microbiol (2007) 0.98
BAC clones generated from sheared DNA. Genomics (2006) 0.96
Risk variants for psoriasis vulgaris in a large case-control collection and association with clinical subphenotypes. Hum Mol Genet (2012) 0.95
Genomic and cytological analysis of the Y chromosome of Drosophila melanogaster: telomere-derived sequences at internal regions. Chromosoma (2004) 0.94
Pim 1 kinase inhibitor ETP-45299 suppresses cellular proliferation and synergizes with PI3K inhibition. Cancer Lett (2010) 0.93
Solution structure of the endonuclease domain from the master replication initiator protein of the nanovirus faba bean necrotic yellows virus and comparison with the corresponding geminivirus and circovirus structures. Biochemistry (2007) 0.92
Differential stability of 2'F-ANA*RNA and ANA*RNA hybrid duplexes: roles of structure, pseudohydrogen bonding, hydration, ion uptake and flexibility. Nucleic Acids Res (2010) 0.92
Protein stabilization and the Hofmeister effect: the role of hydrophobic solvation. Biophys J (2009) 0.91
Four-stranded DNA structure stabilized by a novel G:C:A:T tetrad. J Am Chem Soc (2003) 0.91
Tadalafil crosses the blood-brain barrier and reverses cognitive dysfunction in a mouse model of AD. Neuropharmacology (2012) 0.90
A bacterial antirepressor with SH3 domain topology mimics operator DNA in sequestering the repressor DNA recognition helix. Nucleic Acids Res (2010) 0.90
Polyfluorinated amino acids for sensitive 19F NMR-based screening and kinetic measurements. J Am Chem Soc (2007) 0.90
In vivo, in vitro and in silico methods for small molecule transfer across the BBB. J Pharm Sci (2009) 0.90
Enantioselective synthesis of (+)- and (-)-dihydroepiepoformin and (+)-epiepoformin. Org Lett (2005) 0.90
A dynamic combinatorial approach for the analysis of weak carbohydrate/aromatic complexes: dissecting facial selectivity in CH/π stacking interactions. J Am Chem Soc (2013) 0.90
Backbone FC-H···O hydrogen bonds in 2'F-substituted nucleic acids. Angew Chem Int Ed Engl (2013) 0.89
Trypanosoma cruzi calreticulin: a possible role in Chagas' disease autoimmunity. Mol Immunol (2008) 0.89
Reduced stability and increased dynamics in the human proliferating cell nuclear antigen (PCNA) relative to the yeast homolog. PLoS One (2011) 0.89
Halophilic enzyme activation induced by salts. Sci Rep (2011) 0.89
Fluorine local environment: from screening to drug design. Drug Discov Today (2012) 0.88
NAFlex: a web server for the study of nucleic acid flexibility. Nucleic Acids Res (2013) 0.88
Databases of protein-protein interactions and their use in drug discovery. Curr Opin Drug Discov Devel (2009) 0.88
NMR spectroscopy reveals that RNase A is chiefly denatured in 40% acetic acid: implications for oligomer formation by 3D domain swapping. J Am Chem Soc (2010) 0.87
Ion-channel reconstitution. Methods Mol Biol (2007) 0.87
Solution NMR structure of a human FGF-1 monomer, activated by a hexasaccharide heparin-analogue. FEBS J (2006) 0.87
Solution equilibria of the i-motif-forming region upstream of the B-cell lymphoma-2 P1 promoter. Biochimie (2007) 0.87
Simultaneous chromophobe renal cell carcinoma and squamous renal cell carcinoma. Diagn Pathol (2007) 0.87
Assessment of additive/nonadditive effects in structure-activity relationships: implications for iterative drug design. J Med Chem (2008) 0.87
Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase. J Biol Chem (2010) 0.86
Antiparallel triple helices. Structural characteristics and stabilization by 8-amino derivatives. J Am Chem Soc (2003) 0.86
NMR assignment of the hypothetical rhodanese domain At4g01050 from Arabidopsis thaliana. J Biomol NMR (2004) 0.85
Properties of triple helices formed by parallel-stranded hairpins containing 8-aminopurines. Nucleic Acids Res (2002) 0.85
8-Amino guanine accelerates tetramolecular G-quadruplex formation. Chem Commun (Camb) (2008) 0.85
Combined use of computational chemistry, NMR screening, and X-ray crystallography for identification and characterization of fluorophilic protein environments. Proteins (2010) 0.85
Highly polar carbohydrates stack onto DNA duplexes via CH/π interactions. J Am Chem Soc (2011) 0.85
Enantioselective total synthesis of angucyclinone-type antibiotics rubiginones A(2) and C(2). Angew Chem Int Ed Engl (2002) 0.84
Coverage effects and the nature of the metal-sulfur bond in S/Au(111): high-resolution photoemission and density-functional studies. J Am Chem Soc (2003) 0.84
Mechanism and structure-activity relationships of norspermidine-based peptidic inhibitors of trypanothione reductase. Bioorg Med Chem (2005) 0.83
Conformationally rigid nucleoside probes help understand the role of sugar pucker and nucleobase orientation in the thrombin-binding aptamer. Nucleic Acids Res (2009) 0.83
Increased production of soluble TLR2 by lamina propria mononuclear cells from ulcerative colitis patients. Immunobiology (2011) 0.83
Mechanical unfolding of long human telomeric RNA (TERRA). Chem Commun (Camb) (2013) 0.83
Role of aromatic rings in the molecular recognition of aminoglycoside antibiotics: implications for drug design. J Am Chem Soc (2010) 0.83
A large palindrome with interchromosomal gene duplications in the pericentromeric region of the D. melanogaster Y chromosome. Mol Biol Evol (2011) 0.83
The solution structure of double helical arabino nucleic acids (ANA and 2'F-ANA): effect of arabinoses in duplex-hairpin interconversion. Nucleic Acids Res (2012) 0.83
Solution structure of the rhodanese homology domain At4g01050(175-295) from Arabidopsis thaliana. Protein Sci (2004) 0.83
Getting specificity from simplicity in putative proteins from the prebiotic earth. Proc Natl Acad Sci U S A (2007) 0.83
NMR assignment of the hypothetical ENTH-VHS domain At3g16270 from Arabidopsis thaliana. J Biomol NMR (2004) 0.82
Epigenetic drugs in Alzheimer's disease. Biomol Concepts (2013) 0.82
High-resolution analysis of Drosophila heterochromatin organization using SuUR Su(var)3-9 double mutants. Proc Natl Acad Sci U S A (2007) 0.82
Dramatic effect of furanose C2' substitution on structure and stability: directing the folding of the human telomeric quadruplex with a single fluorine atom. J Am Chem Soc (2013) 0.82
Destabilization of quadruplex DNA by 8-aminoguanine. Chembiochem (2006) 0.82
Novel dimeric structure of phage φ29-encoded protein p56: insights into uracil-DNA glycosylase inhibition. Nucleic Acids Res (2011) 0.82
Formation, structure, and dissociation of the ribonuclease S three-dimensional domain-swapped dimer. J Biol Chem (2006) 0.82
A simple NMR analysis of the protonation equilibrium that accompanies aminoglycoside recognition: dramatic alterations in the neomycin-B protonation state upon binding to a 23-mer RNA aptamer. Chem Commun (Camb) (2006) 0.81
Ovine placenta at high altitudes: comparison of animals with different times of adaptation to hypoxic environment. Anim Reprod Sci (2005) 0.81
Enantioselective synthesis of natural polyoxygenated cyclohexanes and cyclohexenes from [(p-tolylsulfinyl)methyl]-p-quinols. Chemistry (2007) 0.81
Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors. Bioorg Med Chem Lett (2012) 0.81
Rapid identification of ETP-46992, orally bioavailable PI3K inhibitor, selective versus mTOR. Bioorg Med Chem Lett (2012) 0.81
Self-association of short DNA loops through minor groove C:G:G:C tetrads. Nucleic Acids Res (2009) 0.81
The impact of R53C mutation on the three-dimensional structure, stability, and DNA-binding properties of the human Hesx-1 homeodomain. Chembiochem (2002) 0.81
On the origin of the eukaryotic chromosome: the role of noncanonical DNA structures in telomere evolution. Genome Biol Evol (2013) 0.81
Backbone assignment of human proliferating cell nuclear antigen. Biomol NMR Assign (2007) 0.81
Effect of bulky lesions on DNA: solution structure of a DNA duplex containing a cholesterol adduct. J Biol Chem (2004) 0.81
Putative one-pot prebiotic polypeptides with ribonucleolytic activity. Chemistry (2010) 0.81
Corona glans clitoroplasty and urethropreputial vestibuloplasty in male-to-female transsexuals: the vulval aesthetic refinement by the Andalusia Gender Team. Plast Reconstr Surg (2004) 0.80
Proliferating cell nuclear antigen (PCNA) interactions in solution studied by NMR. PLoS One (2012) 0.80
Experimental evidence for the existence of non-exo-anomeric conformations in branched oligosaccharides: NMR analysis of the structure and dynamics of aminoglycosides of the neomycin family. Chemistry (2002) 0.80
Structures and stabilities of small DNA dumbbells with Watson-Crick and Hoogsteen base pairs. Chembiochem (2003) 0.80
Clinical features and predictive factors in psoriatic arthritis-related uveitis. Semin Arthritis Rheum (2002) 0.80
Increased in-vitro and in-vivo biological activity of lipopolysaccharide extracted from clinical low virulence vacA genotype Helicobacter pylori strains. J Med Microbiol (2002) 0.80
Model of an asymmetric DPPC/DPPS membrane: effect of asymmetry on the lipid properties. A molecular dynamics simulation study. J Phys Chem B (2006) 0.80