Palmitate induces reactive oxygen species production and β-cell dysfunction by activating nicotinamide adenine dinucleotide phosphate oxidase through Src signaling.

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Src regulates insulin secretion and glucose metabolism by influencing subcellular localization of glucokinase in pancreatic β-cells. J Diabetes Investig (2015) 0.75

RIG-I inhibits pancreatic β cell proliferation through competitive binding of activated Src. Sci Rep (2016) 0.75

Mitochondrial formation of reactive oxygen species. J Physiol (2003) 10.73

The hunting of the Src. Nat Rev Mol Cell Biol (2001) 3.64

Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicity. Endocrinology (2002) 3.07

Pancreatic islet glucose metabolism and regulation of insulin secretion. Diabetes Metab Rev (1986) 2.77

Role of NADH/NADPH oxidase-derived H2O2 in angiotensin II-induced vascular hypertrophy. Hypertension (1998) 2.70

Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells. J Biol Chem (1999) 2.01

Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation. Cell (2011) 1.76

Visualizing superoxide production in normal and diabetic rat islets of Langerhans. J Biol Chem (2003) 1.65

Src-mediated tyrosine phosphorylation of p47phox in hyperoxia-induced activation of NADPH oxidase and generation of reactive oxygen species in lung endothelial cells. J Biol Chem (2005) 1.57

Pancreatic beta-cells express phagocyte-like NAD(P)H oxidase. Diabetes (2003) 1.46

Glucose, palmitate and pro-inflammatory cytokines modulate production and activity of a phagocyte-like NADPH oxidase in rat pancreatic islets and a clonal beta cell line. Diabetologia (2006) 1.43

Exendin-4 suppresses SRC activation and reactive oxygen species production in diabetic Goto-Kakizaki rat islets in an Epac-dependent manner. Diabetes (2010) 1.43

Sodium palmitate induces partial mitochondrial uncoupling and reactive oxygen species in rat pancreatic islets in vitro. Endocrinology (1999) 1.32

NADPH oxidase 2-derived reactive oxygen species mediate FFAs-induced dysfunction and apoptosis of β-cells via JNK, p38 MAPK and p53 pathways. PLoS One (2010) 1.23

Interference of H2O2 with stimulus-secretion coupling in mouse pancreatic beta-cells. J Physiol (1999) 1.23

Src redox regulation: again in the front line. Free Radic Biol Med (2010) 1.21

Expression of isoforms of NADPH oxidase components in rat pancreatic islets. Life Sci (2006) 1.20

NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes? Biochem Soc Trans (2008) 1.20

Beneficial effects of candesartan, an angiotensin II type 1 receptor blocker, on beta-cell function and morphology in db/db mice. Biochem Biophys Res Commun (2006) 1.14

Disruption of TBP-2 ameliorates insulin sensitivity and secretion without affecting obesity. Nat Commun (2010) 1.13

Increased expression of NAD(P)H oxidase in islets of animal models of Type 2 diabetes and its improvement by an AT1 receptor antagonist. Biochem Biophys Res Commun (2005) 1.12

Induction of COX-2/PGE(2)/IL-6 is crucial for cigarette smoke extract-induced airway inflammation: Role of TLR4-dependent NADPH oxidase activation. Free Radic Biol Med (2009) 1.09

The direct effects of the angiotensin-converting enzyme inhibitors, zofenoprilat and enalaprilat, on isolated human pancreatic islets. Eur J Endocrinol (2006) 1.04

Cigarette smoke particle-phase extract induces HO-1 expression in human tracheal smooth muscle cells: role of the c-Src/NADPH oxidase/MAPK/Nrf2 signaling pathway. Free Radic Biol Med (2010) 1.00

Ouabain suppresses glucose-induced mitochondrial ATP production and insulin release by generating reactive oxygen species in pancreatic islets. Diabetes (2002) 0.94

Diabetic beta-cells can achieve self-protection against oxidative stress through an adaptive up-regulation of their antioxidant defenses. PLoS One (2009) 0.89

Src activation generates reactive oxygen species and impairs metabolism-secretion coupling in diabetic Goto-Kakizaki and ouabain-treated rat pancreatic islets. Diabetologia (2008) 0.89

Role of mitochondrial phosphate carrier in metabolism-secretion coupling in rat insulinoma cell line INS-1. Biochem J (2011) 0.86

Cloning, characterization and tissue distribution of the rat ATP-binding cassette (ABC) transporter ABC2/ABCA2. Biochem J (2000) 0.85