The potential of label-free nonlinear optical molecular microscopy to non-invasively characterize the viability of engineered human tissue constructs.

PubWeight™: 0.81‹?›

🔗 View Article (PMC 4106121)

Published in Biomaterials on May 20, 2014

Authors

Leng-Chun Chen1, William R Lloyd2, Shiuhyang Kuo3, Hyungjin Myra Kim4, Cynthia L Marcelo5, Stephen E Feinberg6, Mary-Ann Mycek7

Author Affiliations

1: Department of Biomedical Engineering, University of Michigan College of Engineering & Medical School, 1101 Beal Avenue, Ann Arbor, MI 48109-2110, USA. Electronic address: lengleng@umich.edu.
2: Department of Biomedical Engineering, University of Michigan College of Engineering & Medical School, 1101 Beal Avenue, Ann Arbor, MI 48109-2110, USA. Electronic address: billlloy@umich.edu.
3: Department of Oral and Maxillofacial Surgery, University of Michigan School of Dentistry, 1150 W. Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address: skuo@med.umich.edu.
4: Center for Statistical Consultation and Research, University of Michigan School of Public Health, 915 E. Washington, Ann Arbor, MI 48109-1070, USA. Electronic address: myrakim@umich.edu.
5: Department of Surgery, University of Michigan Medical School, 1150 W. Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address: cmarcelo@umich.edu.
6: Department of Oral and Maxillofacial Surgery, University of Michigan School of Dentistry, 1150 W. Medical Center Drive, Ann Arbor, MI 48109, USA; Department of Surgery, University of Michigan Medical School, 1150 W. Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address: sefein@med.umich.edu.
7: Department of Biomedical Engineering, University of Michigan College of Engineering & Medical School, 1101 Beal Avenue, Ann Arbor, MI 48109-2110, USA. Electronic address: mycek@umich.edu.

Articles cited by this

Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (2009) 49.82

In vivo multiphoton microscopy of NADH and FAD redox states, fluorescence lifetimes, and cellular morphology in precancerous epithelia. Proc Natl Acad Sci U S A (2007) 4.53

Two-photon fluorescence spectroscopy and microscopy of NAD(P)H and flavoprotein. Biophys J (2002) 4.10

Reconstruction of functional tissues with cell sheet engineering. Biomaterials (2007) 1.75

3D cell culture: a review of current approaches and techniques. Methods Mol Biol (2011) 1.68

Clinical multiphoton tomography. J Biophotonics (2008) 1.49

Two-photon microscopy of deep intravital tissues and its merits in clinical research. J Microsc (2010) 1.40

Imaging challenges in biomaterials and tissue engineering. Biomaterials (2013) 1.28

Intraoral grafting of an ex vivo produced oral mucosa equivalent: a preliminary report. Int J Oral Maxillofac Surg (2003) 1.28

Quantitative molecular sensing in biological tissues: an approach to non-invasive optical characterization. Opt Express (2006) 1.24

Development of a tissue-engineered human oral mucosa: from the bench to the bed side. Cells Tissues Organs (2004) 1.20

Optical spectroscopy and imaging for the noninvasive evaluation of engineered tissues. Tissue Eng Part B Rev (2008) 1.20

Feasibility of using multiphoton excited tissue autofluorescence for in vivo human histopathology. Biomed Opt Express (2010) 1.16

In vivo multiphoton NADH fluorescence reveals depth-dependent keratinocyte metabolism in human skin. Biophys J (2013) 1.13

Diagnostic cellular organization features extracted from autofluorescence images. Opt Lett (2007) 1.05

Clinical and histopathological analysis of healing process of intraoral reconstruction with ex vivo produced oral mucosa equivalent. Kobe J Med Sci (2007) 0.94

Assessment of cell viability in three-dimensional scaffolds using cellular auto-fluorescence. Tissue Eng Part C Methods (2011) 0.90

Risk estimation of skin damage due to ultrashort pulsed, focused near-infrared laser irradiation at 800 nm. J Biomed Opt (2008) 0.89

Autofluorescence characteristics of immortalized and carcinogen-transformed human bronchial epithelial cells. J Biomed Opt (2001) 0.87

Depth-resolved fluorescence spectroscopy reveals layered structure of tissue. Opt Express (2004) 0.85

Fluorescence lifetime imaging microscopy for quantitative biological imaging. Methods Cell Biol (2013) 0.81

Characterization of squamous cell carcinoma in an organotypic culture via subsurface non-linear optical molecular imaging. Exp Biol Med (Maywood) (2013) 0.79