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A Conserved DNA Repeat Promotes Selection of a Diverse Repertoire of Trypanosoma brucei Surface Antigens from the Genomic Archive. PLoS Genet (2016) 0.76

A vanillic acid inducible expression system for Trypanosoma brucei. Mol Biochem Parasitol (2016) 0.75

Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents. Bioorg Med Chem (2016) 0.75

The VEXing problem of monoallelic expression in the African trypanosome. Proc Natl Acad Sci U S A (2016) 0.75

A multigene family encoding surface glycoproteins in Trypanosoma congolense. Microb Cell (2017) 0.75

Dynein Light Chain LC8 Is Required for RNA Polymerase I-Mediated Transcription in Trypanosoma brucei, Facilitating Assembly and Promoter Binding of Class I Transcription Factor A. Mol Cell Biol (2015) 0.75

Metabolomics Identifies Multiple Candidate Biomarkers to Diagnose and Stage Human African Trypanosomiasis. PLoS Negl Trop Dis (2016) 0.75

Subverting lysosomal function in Trypanosoma brucei. Microb Cell (2015) 0.75

A novel protein kinase is essential in bloodstream Trypanosoma brucei. Int J Parasitol (2016) 0.75

Activity of Bisnaphthalimidopropyl Derivatives against Trypanosoma brucei. Antimicrob Agents Chemother (2016) 0.75

An Overview of Trypanosoma brucei Infections: An Intense Host-Parasite Interaction. Front Microbiol (2016) 0.75

High-resolution analysis of multi-copy variant surface glycoprotein gene expression sites in African trypanosomes. BMC Genomics (2016) 0.75

A Receptor's Tale: An Eon in the Life of a Trypanosome Receptor. PLoS Pathog (2017) 0.75

A proteomics approach reveals molecular manipulators of distinct cellular processes in the salivary glands of Glossina m. morsitans in response to Trypanosoma b. brucei infections. Parasit Vectors (2016) 0.75

Genome-wide RNAi selection identifies a regulator of transmission stage-enriched gene families and cell-type differentiation in Trypanosoma brucei. PLoS Pathog (2017) 0.75

Evolutionary diversification of the trypanosome haptoglobin-haemoglobin receptor from an ancestral haemoglobin receptor. Elife (2016) 0.75

Well-positioned nucleosomes punctuate polycistronic pol II transcription units and flank silent VSG gene arrays in Trypanosoma brucei. Epigenetics Chromatin (2017) 0.75

A Gene of the β3-Glycosyltransferase Family Encodes N-Acetylglucosaminyltransferase II Function in Trypanosoma brucei. J Biol Chem (2016) 0.75

Synchronous expression of individual metacyclic variant surface glycoprotein genes in Trypanosoma brucei. Mol Biochem Parasitol (2015) 0.75

The proteome and transcriptome of the infectious metacyclic form of Trypanosoma brucei define quiescent cells primed for mammalian invasion. Mol Microbiol (2017) 0.75

The Cytological Events and Molecular Control of Life Cycle Development of Trypanosoma brucei in the Mammalian Bloodstream. Pathogens (2017) 0.75

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Antigenic variation in Trypanosoma brucei analyzed by electrophoretic separation of chromosome-sized DNA molecules. Cell (1984) 4.03

Activation of trypanosome surface glycoprotein genes involves a duplication-transposition leading to an altered 3' end. Cell (1981) 3.65

Four histone variants mark the boundaries of polycistronic transcription units in Trypanosoma brucei. Genes Dev (2009) 3.62

Glycosyl-phosphatidylinositol moiety that anchors Trypanosoma brucei variant surface glycoprotein to the membrane. Science (1988) 3.41

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Growth of chromosome ends in multiplying trypanosomes. Nature (1983) 3.16

A VSG expression site-associated gene confers resistance to human serum in Trypanosoma rhodesiense. Cell (1998) 3.08

Inactivation of transcription by UV irradiation of T. brucei provides evidence for a multicistronic transcription unit including a VSG gene. Cell (1987) 2.93

Identification of a telomeric DNA sequence in Trypanosoma brucei. Cell (1984) 2.89

RNA splicing is required to make the messenger RNA for a variant surface antigen in trypanosomes. Nucleic Acids Res (1982) 2.87

Hydrodynamic flow-mediated protein sorting on the cell surface of trypanosomes. Cell (2007) 2.84

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Genomic environment of the expression-linked extra copies of genes for surface antigens of Trypanosoma brucei resembles the end of a chromosome. Nature (1982) 2.75

Alpha-amanitin-insensitive transcription of variant surface glycoprotein genes provides further evidence for discontinuous transcription in trypanosomes. Nucleic Acids Res (1984) 2.74

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A pol I transcriptional body associated with VSG mono-allelic expression in Trypanosoma brucei. Nature (2001) 2.59

Transcripts coding for variant surface glycoproteins of Trypanosoma brucei have a short, identical exon at their 5' end. Gene (1982) 2.58

Discontinuous synthesis of mRNA in trypanosomes. EMBO J (1984) 2.57

A novel pathway for glycan assembly: biosynthesis of the glycosyl-phosphatidylinositol anchor of the trypanosome variant surface glycoprotein. Cell (1989) 2.56

High-throughput decoding of antitrypanosomal drug efficacy and resistance. Nature (2012) 2.55

Novel expression-linked copies of the genes for variant surface antigens in trypanosomes. Nature (1980) 2.51

The promoter for a variant surface glycoprotein gene expression site in Trypanosoma brucei. EMBO J (1990) 2.41

The genes and transcripts of an antigen gene expression site from T. brucei. Cell (1989) 2.36

Genomic rearrangements correlated with antigenic variation in Trypanosoma brucei. Nature (1980) 2.30

Telomeric expression sites are highly conserved in Trypanosoma brucei. PLoS One (2008) 2.22

RNA polymerase I transcribes procyclin genes and variant surface glycoprotein gene expression sites in Trypanosoma brucei. Eukaryot Cell (2003) 2.16

Genomic environment of T. brucei VSG genes: presence of a minichromosome. Nature (1982) 2.08

The trypanosome flagellar pocket. Nat Rev Microbiol (2009) 2.07

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Gene conversion as a mechanism for antigenic variation in trypanosomes. Cell (1983) 1.97

Developmental progression to infectivity in Trypanosoma brucei triggered by an RNA-binding protein. Science (2012) 1.94

Coordinate transcription of variant surface glycoprotein genes and an expression site associated gene family in Trypanosoma brucei. Cell (1985) 1.92

t-loops at trypanosome telomeres. EMBO J (2001) 1.91

A structural motif in the variant surface glycoproteins of Trypanosoma brucei. Nature (1993) 1.77

A histone methyltransferase modulates antigenic variation in African trypanosomes. PLoS Biol (2008) 1.72

Analysis of the VSG gene silent archive in Trypanosoma brucei reveals that mosaic gene expression is prominent in antigenic variation and is favored by archive substructure. Genome Res (2007) 1.68

Two modes of activation of a single surface antigen gene of Trypanosoma brucei. Cell (1984) 1.67

Molecular mechanisms underlying the control of antigenic variation in African trypanosomes. Curr Opin Microbiol (2010) 1.64

A developmentally regulated position effect at a telomeric locus in Trypanosoma brucei. Cell (1995) 1.62

Trypanosome spliced leader RNA genes contain the first identified RNA polymerase II gene promoter in these organisms. Nucleic Acids Res (2001) 1.60

A ribosomal DNA promoter replacing the promoter of a telomeric VSG gene expression site can be efficiently switched on and off in T. brucei. Cell (1995) 1.60

The expression-linked copy of a surface antigen gene in Trypanosoma is probably the one transcribed. Nature (1981) 1.60

Cloning and characterization of DNA sequences complementary to messenger ribonucleic acids coding for the synthesis of two surface antigens of Trypanosoma brucei. Nucleic Acids Res (1980) 1.60

Variant surface glycoprotein RNA interference triggers a precytokinesis cell cycle arrest in African trypanosomes. Proc Natl Acad Sci U S A (2005) 1.58

RAP1 is essential for silencing telomeric variant surface glycoprotein genes in Trypanosoma brucei. Cell (2009) 1.55

Alpha-amanitin-resistant transcription units in trypanosomes: a comparison of promoter sequences for a VSG gene expression site and for the ribosomal RNA genes. Nucleic Acids Res (1991) 1.54

Nucleosomes are depleted at the VSG expression site transcribed by RNA polymerase I in African trypanosomes. Eukaryot Cell (2009) 1.52

Active VSG expression sites in Trypanosoma brucei are depleted of nucleosomes. Eukaryot Cell (2009) 1.51

A role for RAD51 and homologous recombination in Trypanosoma brucei antigenic variation. Genes Dev (1999) 1.51

Comparative SILAC proteomic analysis of Trypanosoma brucei bloodstream and procyclic lifecycle stages. PLoS One (2012) 1.50

Probabilistic order in antigenic variation of Trypanosoma brucei. Int J Parasitol (2005) 1.49

Transcription of the intergenic regions of the tubulin gene cluster of Trypanosoma brucei: evidence for a polycistronic transcription unit in a eukaryote. Nucleic Acids Res (1987) 1.47

Glucosylated hydroxymethyluracil, DNA base J, prevents transcriptional readthrough in Leishmania. Cell (2012) 1.46

Differential RNA elongation controls the variant surface glycoprotein gene expression sites of Trypanosoma brucei. Mol Microbiol (2000) 1.45

A yeast-endonuclease-generated DNA break induces antigenic switching in Trypanosoma brucei. Nature (2009) 1.44

DNA rearrangements involving the genes for variant antigens in Trypanosoma brucei. Cold Spring Harb Symp Quant Biol (1981) 1.41

The 3'-terminal region of the mRNAs for VSG and procyclin can confer stage specificity to gene expression in Trypanosoma brucei. EMBO J (1995) 1.34

Sequence homology and microhomology dominate chromosomal double-strand break repair in African trypanosomes. Nucleic Acids Res (2008) 1.32

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Crossreacting determinants in the C-terminal region of trypanosome variant surface antigens. Nature (1979) 1.31

Homologous 3'-terminal regions of mRNAs for surface antigens of different antigenic variants of Trypanosoma brucei. Nucleic Acids Res (1981) 1.31

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The rate of antigenic variation in fly-transmitted and syringe-passaged infections of Trypanosoma brucei. FEMS Microbiol Lett (1997) 1.29

Mechanism of Trypanosoma brucei gambiense resistance to human serum. Nature (2013) 1.28

Control of variant surface glycoprotein gene-expression sites in Trypanosoma brucei. EMBO J (1999) 1.24

Hemizygous subtelomeres of an African trypanosome chromosome may account for over 75% of chromosome length. Genome Res (2006) 1.24

Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species. Proc Natl Acad Sci U S A (2012) 1.22

Degradation, recycling, and shedding of Trypanosoma brucei variant surface glycoprotein. J Protozool (1991) 1.20

Subnuclear localization of the active variant surface glycoprotein gene expression site in Trypanosoma brucei. Proc Natl Acad Sci U S A (1998) 1.20

The small chromosomes of Trypanosoma brucei involved in antigenic variation are constructed around repetitive palindromes. Genome Res (2004) 1.20

Multifunctional class I transcription in Trypanosoma brucei depends on a novel protein complex. EMBO J (2007) 1.20

Frequent independent duplicative transpositions activate a single VSG gene. Mol Cell Biol (1987) 1.19

Adenylate cyclases of Trypanosoma brucei inhibit the innate immune response of the host. Science (2012) 1.19

Nuclear repositioning of the VSG promoter during developmental silencing in Trypanosoma brucei. J Cell Biol (2007) 1.18

Antigenic variation in clones of animal-infective Trypanosoma brucei derived and maintained in vitro. Parasitology (1980) 1.17

The role of transferrin-receptor variation in the host range of Trypanosoma brucei. Nature (1998) 1.17

Trypanosoma brucei BRCA2 acts in antigenic variation and has undergone a recent expansion in BRC repeat number that is important during homologous recombination. Mol Microbiol (2008) 1.15

Telomere structure and function in trypanosomes: a proposal. Nat Rev Microbiol (2006) 1.13

Telomeric reciprocal recombination as a possible mechanism for antigenic variation in trypanosomes. Nature (1985) 1.12

TOPO3alpha influences antigenic variation by monitoring expression-site-associated VSG switching in Trypanosoma brucei. PLoS Pathog (2010) 1.11

Two mechanisms of expression of a predominant variant antigen gene of Trypanosoma brucei. Nature (1984) 1.10

A cell-surface phylome for African trypanosomes. PLoS Negl Trop Dis (2013) 1.09

Two thymidine hydroxylases differentially regulate the formation of glucosylated DNA at regions flanking polymerase II polycistronic transcription units throughout the genome of Trypanosoma brucei. Nucleic Acids Res (2010) 1.08

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Translocation alters the activation rate of a trypanosome surface antigen gene. Nucleic Acids Res (1984) 1.03

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High affinity nanobodies against the Trypanosome brucei VSG are potent trypanolytic agents that block endocytosis. PLoS Pathog (2011) 1.01

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Mosaic VSGs and the scale of Trypanosoma brucei antigenic variation. PLoS Pathog (2013) 1.00

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