Published in Ageing Res Rev on June 05, 2014
Biochemical Genetic Pathways that Modulate Aging in Multiple Species. Cold Spring Harb Perspect Med (2015) 0.81
Cellular Senescence as the Causal Nexus of Aging. Front Genet (2016) 0.80
Convergent adaptation of cellular machineries in the evolution of large body masses and long life spans. Biogerontology (2017) 0.78
Structure, Distribution, and Function of Neuronal/Synaptic Spinules and Related Invaginating Projections. Neuromolecular Med (2015) 0.77
Planarians as a model of aging to study the interaction between stem cells and senescent cells in vivo. Pathobiol Aging Age Relat Dis (2015) 0.75
The cell survival pathways of the primordial RNA-DNA complex remain conserved in the extant genomes and may function as proto-oncogenes. Eur J Microbiol Immunol (Bp) (2015) 0.75
The Piwi-piRNA pathway: road to immortality. Aging Cell (2017) 0.75
A C. elegans mutant that lives twice as long as wild type. Nature (1993) 20.42
The hallmarks of aging. Cell (2013) 14.29
Adapting proteostasis for disease intervention. Science (2008) 13.22
Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature (2003) 12.10
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature (2002) 10.52
The endocrine regulation of aging by insulin-like signals. Science (2003) 8.10
Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science (2001) 7.85
The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature (1999) 7.85
DNA damage, aging, and cancer. N Engl J Med (2009) 7.56
The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans. Nature (2008) 6.69
Calorie restriction--the SIR2 connection. Cell (2005) 6.51
SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell (2009) 6.09
The DNA damage response and cancer therapy. Nature (2012) 5.25
Myxozoan genera: definition and notes on taxonomy, life-cycle terminology and pathogenic species. Folia Parasitol (Praha) (2006) 4.79
Fundamentals of planarian regeneration. Annu Rev Cell Dev Biol (2004) 4.60
The genome of the ctenophore Mnemiopsis leidyi and its implications for cell type evolution. Science (2013) 4.07
The sirtuin SIRT6 regulates lifespan in male mice. Nature (2012) 4.07
Association of FOXO3A variation with human longevity confirmed in German centenarians. Proc Natl Acad Sci U S A (2009) 4.02
Stem cells, ageing and the quest for immortality. Nature (2006) 3.89
High incidence of non-random template strand segregation and asymmetric fate determination in dividing stem cells and their progeny. PLoS Biol (2007) 3.76
Clonogenic neoblasts are pluripotent adult stem cells that underlie planarian regeneration. Science (2011) 3.72
Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet (1989) 3.69
Geriatric muscle stem cells switch reversible quiescence into senescence. Nature (2014) 3.34
The unicellular ancestry of animal development. Dev Cell (2004) 3.29
Mitochondrial DNA mutations in disease and aging. Environ Mol Mutagen (2010) 3.10
Not your father's planarian: a classic model enters the era of functional genomics. Nat Rev Genet (2002) 3.06
Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing. Nat Cell Biol (2008) 2.93
Mortality patterns suggest lack of senescence in hydra. Exp Gerontol (1998) 2.91
Mechanisms of germ cell specification across the metazoans: epigenesis and preformation. Development (2003) 2.87
DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice. Nat Genet (2008) 2.77
Senescence in a bacterium with asymmetric division. Science (2003) 2.50
Diversity of ageing across the tree of life. Nature (2013) 2.43
The role of nuclear lamin B1 in cell proliferation and senescence. Genes Dev (2011) 2.38
Molecular phylogeny of choanoflagellates, the sister group to Metazoa. Proc Natl Acad Sci U S A (2008) 2.24
The cellular basis for animal regeneration. Dev Cell (2011) 2.14
Whole lifespan microscopic observation of budding yeast aging through a microfluidic dissection platform. Proc Natl Acad Sci U S A (2012) 2.13
Long-term dynamics of adaptation in asexual populations. Science (2013) 2.09
Lamin B1 loss is a senescence-associated biomarker. Mol Biol Cell (2012) 2.03
Thirty-thousand-year-old distant relative of giant icosahedral DNA viruses with a pandoravirus morphology. Proc Natl Acad Sci U S A (2014) 1.95
Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan. Nat Cell Biol (2012) 1.94
Glutamate and neurotrophic factors in neuronal plasticity and disease. Ann N Y Acad Sci (2008) 1.94
Prelamin A acts to accelerate smooth muscle cell senescence and is a novel biomarker of human vascular aging. Circulation (2010) 1.93
Protein homeostasis and the phenotypic manifestation of genetic diversity: principles and mechanisms. Annu Rev Genet (2010) 1.88
The planarian Schmidtea mediterranea as a model for epigenetic germ cell specification: analysis of ESTs from the hermaphroditic strain. Proc Natl Acad Sci U S A (2005) 1.85
Regeneration in the metazoans: why does it happen? Bioessays (2000) 1.84
Protein homeostasis and aging: The importance of exquisite quality control. Ageing Res Rev (2010) 1.84
Regeneration of whole fertile plants from 30,000-y-old fruit tissue buried in Siberian permafrost. Proc Natl Acad Sci U S A (2012) 1.72
Regeneration of hydra from reaggregated cells. Nat New Biol (1972) 1.69
Mitochondrial dysfunction as a cause of ageing. J Intern Med (2008) 1.69
Reactive oxygen species production by mitochondria. Methods Mol Biol (2009) 1.69
A neural signaling triumvirate that influences ageing and age-related disease: insulin/IGF-1, BDNF and serotonin. Ageing Res Rev (2004) 1.68
Energy intake and exercise as determinants of brain health and vulnerability to injury and disease. Cell Metab (2012) 1.64
Nice neighborhood: emerging concepts of the stem cell niche. Cell (2014) 1.63
Adult somatic stem cells in the human parasite Schistosoma mansoni. Nature (2013) 1.61
Replicative senescence of mesenchymal stem cells causes DNA-methylation changes which correlate with repressive histone marks. Aging (Albany NY) (2011) 1.58
nanos function is essential for development and regeneration of planarian germ cells. Proc Natl Acad Sci U S A (2007) 1.56
Extreme longevity in proteinaceous deep-sea corals. Proc Natl Acad Sci U S A (2009) 1.56
Mitochondrial quality control during inheritance is associated with lifespan and mother-daughter age asymmetry in budding yeast. Aging Cell (2011) 1.54
Multiple Wnts are involved in Hydra organizer formation and regeneration. Dev Biol (2009) 1.54
Cell differentiation and morphogenesis in the colony-forming choanoflagellate Salpingoeca rosetta. Dev Biol (2011) 1.53
Stem cell systems and regeneration in planaria. Dev Genes Evol (2012) 1.51
The power of regeneration and the stem-cell kingdom: freshwater planarians (Platyhelminthes). Bioessays (2006) 1.50
Mechanisms of protein-folding diseases at a glance. Dis Model Mech (2014) 1.45
FOXO in aging: did evolutionary diversification of FOXO function distract it from prolonging life? Bioessays (2013) 1.45
Clonal dynamics in western North American aspen (Populus tremuloides). Mol Ecol (2008) 1.43
The molecular logic for planarian regeneration along the anterior-posterior axis. Nature (2013) 1.41
Rethinking differentiation: stem cells, regeneration, and plasticity. Cell (2014) 1.41
Do perennials really senesce? Trends Plant Sci (2008) 1.39
Reactivating head regrowth in a regeneration-deficient planarian species. Nature (2013) 1.35
Cellular and molecular dissection of pluripotent adult somatic stem cells in planarians. Dev Growth Differ (2010) 1.34
Growing old: metabolic control and yeast aging. Annu Rev Microbiol (2002) 1.32
Gene expression of pluripotency determinants is conserved between mammalian and planarian stem cells. EMBO J (2012) 1.31
Restoration of anterior regeneration in a planarian with limited regenerative ability. Nature (2013) 1.29
Mitochondrial function as a determinant of life span. Pflugers Arch (2009) 1.27
Genomic organization, evolution, and expression of photoprotein and opsin genes in Mnemiopsis leidyi: a new view of ctenophore photocytes. BMC Biol (2012) 1.23
Histone methylation makes its mark on longevity. Trends Cell Biol (2011) 1.21
Aging and long-term temporal regulation in ciliated protozoa. A critical review. Mech Ageing Dev (1975) 1.19
Overfeeding and life span in Tokophrya infusionum. J Gerontol (1952) 1.19
Hydra and the evolution of stem cells. Bioessays (2009) 1.18
FoxO is a critical regulator of stem cell maintenance in immortal Hydra. Proc Natl Acad Sci U S A (2012) 1.17
Echinococcus multilocularis as an experimental model in stem cell research and molecular host-parasite interaction. Parasitology (2009) 1.14
Molecular phylogeny of unikonts: new insights into the position of apusomonads and ancyromonads and the internal relationships of opisthokonts. Protist (2012) 1.14
Fission yeast does not age under favorable conditions, but does so after stress. Curr Biol (2013) 1.12
Stem cells are differentially regulated during development, regeneration and homeostasis in flatworms. Dev Biol (2009) 1.11
Evolution and regeneration of the planarian central nervous system. Dev Growth Differ (2009) 1.11
Why polyps regenerate and we don't: towards a cellular and molecular framework for Hydra regeneration. Dev Biol (2006) 1.10
Somatic stem cells express Piwi and Vasa genes in an adult ctenophore: ancient association of "germline genes" with stemness. Dev Biol (2010) 1.10
Induced stem cell neoplasia in a cnidarian by ectopic expression of a POU domain transcription factor. Development (2011) 1.09
The sirtuins, oxidative stress and aging: an emerging link. Aging (Albany NY) (2013) 1.08
The use of a protozoan for studies on aging. I. Differences between young and old organisms of Tokophyra infusionum as revealed by light and electron microscopy. J Gerontol (1961) 1.08
Closing the circle of germline and stem cells: the Primordial Stem Cell hypothesis. Evodevo (2013) 1.07
Choanoflagellate lorica construction and assembly: the nudiform condition. I. Savillea species. Protist (2007) 1.06
Radical modification of the A-P axis and the evolution of asexual reproduction in Convolutriloba acoels. Evol Dev (2008) 1.06
Telomere maintenance and telomerase activity are differentially regulated in asexual and sexual worms. Proc Natl Acad Sci U S A (2012) 1.06
Genes, mitochondria and aging in filamentous fungi. Ageing Res Rev (2002) 1.06
Hormesis/preconditioning mechanisms, the nervous system and aging. Ageing Res Rev (2006) 1.04
The Trox-2 Hox/ParaHox gene of Trichoplax (Placozoa) marks an epithelial boundary. Dev Genes Evol (2004) 1.04
The budding yeast, Saccharomyces cerevisiae, as a model for aging research: a critical review. Mech Ageing Dev (2000) 1.02
Characterization of the stem cell system of the acoel Isodiametra pulchra. BMC Dev Biol (2009) 1.02
Regeneration, stem cells, and the evolution of tumor suppression. Cold Spring Harb Symp Quant Biol (2009) 1.01
Communication breakdown: the impact of ageing on synapse structure. Ageing Res Rev (2014) 0.92