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The journal impact factor: too much of an impact? Ann Acad Med Singapore (2006) 2.98

Targeted inhibition of the extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) in the treatment of hepatocellular carcinoma. Mol Cancer Ther (2007) 2.01

Oncogenic pathway combinations predict clinical prognosis in gastric cancer. PLoS Genet (2009) 1.96

Bevacizumab and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma. J Hepatol (2008) 1.87

The effect of photodynamic therapy on tumor angiogenesis. Cell Mol Life Sci (2009) 1.62

A combined comparative genomic hybridization and expression microarray analysis of gastric cancer reveals novel molecular subtypes. Cancer Res (2003) 1.60

Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma. Clin Cancer Res (2008) 1.57

Over-expression of the mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK in hepatocellular carcinoma: its role in tumor progression and apoptosis. BMC Gastroenterol (2003) 1.55

Serglycin is a theranostic target in nasopharyngeal carcinoma that promotes metastasis. Cancer Res (2011) 1.49

Loss of parafibromin immunoreactivity is a distinguishing feature of parathyroid carcinoma. Clin Cancer Res (2004) 1.47

Postoperative endocrine function in patients with surgically treated thyrotoxicosis. Head Neck (2004) 1.42

Sorafenib and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma. J Cell Mol Med (2009) 1.30

Nanoparticles in photodynamic therapy. Chem Rev (2015) 1.26

RAD001 (everolimus) inhibits tumour growth in xenograft models of human hepatocellular carcinoma. J Cell Mol Med (2008) 1.19

AZD6244 enhances the anti-tumor activity of sorafenib in ectopic and orthotopic models of human hepatocellular carcinoma (HCC). J Hepatol (2009) 1.12

Retroperitoneal liposarcomas: the experience of a tertiary Asian center. World J Surg Oncol (2011) 1.10

Xenografts of human hepatocellular carcinoma: a useful model for testing drugs. Clin Cancer Res (2006) 1.07

Sorafenib induces growth suppression in mouse models of gastrointestinal stromal tumor. Mol Cancer Ther (2009) 1.07

Head & neck optical diagnostics: vision of the future of surgery. Head Neck Oncol (2009) 1.05

Primary malignant melanoma of the esophagus with multiple esophageal lesions. Nat Clin Pract Gastroenterol Hepatol (2007) 1.00

Cancer trends and incidences in Singapore. Jpn J Clin Oncol (2013) 0.97

Bevacizumab and rapamycin inhibit tumor growth in peritoneal model of human ovarian cancer. Mol Cancer Ther (2007) 0.95

Amplification and overexpression of PPFIA1, a putative 11q13 invasion suppressor gene, in head and neck squamous cell carcinoma. Genes Chromosomes Cancer (2008) 0.95

Early diagnosis of oral cancer based on the surface plasmon resonance of gold nanoparticles. Int J Nanomedicine (2007) 0.95

Foretinib demonstrates anti-tumor activity and improves overall survival in preclinical models of hepatocellular carcinoma. Angiogenesis (2011) 0.93

AZD6244 (ARRY-142886) enhances the therapeutic efficacy of sorafenib in mouse models of gastric cancer. Mol Cancer Ther (2009) 0.93

Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal mesothelioma. Ann Acad Med Singapore (2013) 0.92

A global partnership in medical education between Duke University and the National University of Singapore. Acad Med (2008) 0.91

The use of digitized endoscopic imaging of 5-ALA-induced PPIX fluorescence to detect and diagnose oral premalignant and malignant lesions in vivo. Int J Cancer (2004) 0.91

Dovitinib demonstrates antitumor and antimetastatic activities in xenograft models of hepatocellular carcinoma. J Hepatol (2011) 0.90

Targeting EGFR with photodynamic therapy in combination with Erbitux enhances in vivo bladder tumor response. Mol Cancer (2009) 0.90

Prolonged survival following maximal cytoreductive effort for peritoneal metastases from recurrent granulosa cell tumor of the ovary. J Gynecol Oncol (2011) 0.90

Hypericin-photodynamic therapy (PDT) using an alternative treatment regime suitable for multi-fraction PDT. J Photochem Photobiol B (2005) 0.89

Improved formulation of photosensitizer chlorin e6 polyvinylpyrrolidone for fluorescence diagnostic imaging and photodynamic therapy of human cancer. Eur J Pharm Biopharm (2008) 0.88

Novel photodynamic diagnosis of bladder cancer: ex vivo fluorescence cytology using hypericin. Int J Oncol (2003) 0.87

2011 Young Surgeon's Award Winner: high endothelial venules: a novel prognostic marker in cancer metastasis and the missing link? Ann Acad Med Singapore (2012) 0.86

Anti-angiogenic effects of Hypericin-photodynamic therapy in combination with Celebrex in the treatment of human nasopharyngeal carcinoma. Int J Mol Med (2005) 0.86

Clinical validation of a customized multiple signature microarray for breast cancer. Clin Cancer Res (2008) 0.85

Optimal excitation-emission wavelengths for autofluorescence diagnosis of bladder tumors. Int J Cancer (2003) 0.85

Confocal endomicroscopic imaging of normal and neoplastic human tongue tissue using ALA-induced-PPIX fluorescence: a preliminary study. Oncol Rep (2004) 0.85

Titania coated upconversion nanoparticles for near-infrared light triggered photodynamic therapy. ACS Nano (2015) 0.85

Photolon™ --photosensitization induces apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes. Int J Oncol (2011) 0.83

Tobacco: deadly in any form or disguise. Lancet (2006) 0.83

Detection of squamous cell carcinomas and pre-cancerous lesions in the oral cavity by quantification of 5-aminolevulinic acid induced fluorescence endoscopic images. Lasers Surg Med (2002) 0.82

On-table diagnostic accuracy and the clinical significance of routine exploration in open appendectomies. Asian J Surg (2005) 0.82

Squamous cell carcinoma of the head and neck (HNSCC)--multi-modality treatment and impact on survival. Asian J Surg (2002) 0.81

Renal pelvis squamous cell carcinoma with inferior vena cava infiltration: Case report and review of the literature. Int J Surg Case Rep (2014) 0.81

Effect of hypericin-mediated photodynamic therapy on the expression of vascular endothelial growth factor in human nasopharyngeal carcinoma. Int J Mol Med (2007) 0.81

Investigation into a surface plasmon related heating effect in surface enhanced Raman spectroscopy. Anal Chem (2007) 0.81

Detection of neoplasms in the oral cavity by digitized endoscopic imaging of 5-aminolevulinic acid-induced protoporphyrin IX fluorescence. Int J Oncol (2002) 0.80

Transport of hypericin across chick chorioallantoic membrane and photodynamic therapy vasculature assessment. Biol Pharm Bull (2005) 0.79

First somatic mutation of E2F1 in a critical DNA binding residue discovered in well-differentiated papillary mesothelioma of the peritoneum. Genome Biol (2011) 0.79

A study of 5-aminolevulinic acid and its methyl ester used in in vitro and in vivo systems of human bladder cancer. Int J Oncol (2003) 0.78

Macro-microscopic fluorescence of human bladder cancer using hypericin fluorescence cystoscopy and laser confocal microscopy. Int J Oncol (2003) 0.78

Delivery of hypericin for photodynamic applications. Cancer Lett (2005) 0.78

Enhanced photodynamic activity of hypericin by penetration enhancer N-methyl pyrrolidone formulations in the chick chorioallantoic membrane model. Cancer Lett (2005) 0.77

Superiority of N-methyl pyrrolidone over albumin with hypericin for fluorescence diagnosis of human bladder cancer cells implanted in the chick chorioallantoic membrane model. J Photochem Photobiol B (2006) 0.77

Spectroscopic characterization and photobleaching kinetics of hypericin-N-methyl pyrrolidone formulations. Photochem Photobiol Sci (2006) 0.77

A study comparing endogenous protoporphyrin IX induced by 5-ALA and ALA-methyl ester with exogenous PpIX and PpIX dimethyl ester in photodynamic diagnosis of human nasopharyngeal carcinoma xenografts. Int J Oncol (2006) 0.77

In-vivo optical detection of cancer using chlorin e6--polyvinylpyrrolidone induced fluorescence imaging and spectroscopy. BMC Med Imaging (2009) 0.77

Quality of life after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: an Asian perspective. Ann Surg Oncol (2013) 0.76

Surgical management of colorectal peritoneal metastases: treatment and outcomes compared with hepatic metastases. J Gastrointest Cancer (2013) 0.76

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in Asian patients: 100 consecutive patients in a single institution. Ann Surg Oncol (2013) 0.76

Ovarian preservation with subcutaneous transposition in the setting of cytoreductive surgery. Int J Surg Case Rep (2013) 0.75

Medullary thyroid carcinoma in ethnic Chinese with MEN2A: a case report and literature review. J Pediatr Surg (2013) 0.75

A comparison of protoporphyrin IX and protoporphyrin IX dimethyl ester as a photosensitizer in poorly differentiated human nasopharyngeal carcinoma cells. Photochem Photobiol (2002) 0.75

Endovascular Aneurysm Repair (EVAR) of an Infrarenal Abdominal Aortic Aneurysm (AAA) in a Young Patient with Systemic Lupus Erythematosus (SLE). EJVES Short Rep (2017) 0.75

Deposition method for preparing SERS-active gold nanoparticle substrates. Anal Chem (2005) 0.75

An evaluation of exogenous application of protoporphyrin IX and its dimethyl ester as a photodynamic diagnostic agent in poorly differentiated human nasopharyngeal carcinoma. Photochem Photobiol (2004) 0.75

Macro-microscopic fluorescence imaging of human NPC xenografts in a murine model using topical vs intravenous administration of 5-aminolevulinic acid. Int J Oncol (2002) 0.75

Effects of N-methyl pyrrolidone on the uptake of hypericin in human bladder carcinoma and co-staining with DAPI investigated by confocal microscopy. Technol Cancer Res Treat (2007) 0.75