PubRank

Nicola J Hewitt

Author PubWeight™ 12.73‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol 2013 3.00
2 A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: eye irritation. Regul Toxicol Pharmacol 2009 0.94
3 Generation of proliferating human hepatocytes using Upcyte® technology: characterisation and applications in induction and cytotoxicity assays. Xenobiotica 2012 0.87
4 The reconstructed skin micronucleus assay (RSMN) in EpiDerm™: detailed protocol and harmonized scoring atlas. Mutat Res 2010 0.82
5 Evaluation of chemicals requiring metabolic activation in the EpiDerm™ 3D human reconstructed skin micronucleus (RSMN) assay. Mutat Res 2012 0.82
6 International prevalidation studies of the EpiDerm 3D human reconstructed skin micronucleus (RSMN) assay: transferability and reproducibility. Mutat Res 2010 0.81
7 A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: genotoxicity. A COLIPA analysis. Regul Toxicol Pharmacol 2010 0.81
8 Optimization of upcyte® human hepatocytes for the in vitro micronucleus assay. Mutat Res 2013 0.80
9 Differential in vitro hepatotoxicity of troglitazone and rosiglitazone among cryopreserved human hepatocytes from 37 donors. Chem Biol Interact 2002 0.79
10 Prediction of hepatic clearance using cryopreserved human hepatocytes: a comparison of serum and serum-free incubations. J Pharm Pharmacol 2006 0.79
11 The effect of EGF and the comitogen, norepinephrine, on the proliferative responses of fresh and cryopreserved rat and mouse hepatocytes. Cryobiology 2006 0.77
12 A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: skin irritation. Regul Toxicol Pharmacol 2009 0.77
13 An estimate of the number of hepatocyte donors required to provide reasonable estimates of human hepatic clearance from in vitro experiments. Drug Metab Lett 2007 0.77
14 A novel strategy for ADME screening of prodrugs: combined use of serum and hepatocytes to integrate bioactivation and clearance, and predict exposure to both active and prodrug to the systemic circulation. J Pharm Sci 2014 0.75
15 Dermal xenobiotic metabolism: a comparison between native human skin, four in vitro skin test systems and a liver system. Skin Pharmacol Physiol 2014 0.75
16 Effects of the genotoxic compounds, benzo[a]pyrene and cyclophosphamide on phase 1 and 2 activities in EpiDerm™ models. Xenobiotica 2011 0.75