The combination of circulating Ang1 and Tie2 levels predicts progression-free survival advantage in bevacizumab-treated patients with ovarian cancer.

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Published in Clin Cancer Res on June 19, 2014

Authors

Alison Backen1, Andrew G Renehan2, Andrew R Clamp3, Carlo Berzuini4, Cong Zhou1, Amit Oza5, Selina Bannoo6, Stefan J Scherer7, Rosamonde E Banks8, Caroline Dive1, Gordon C Jayson9

Author Affiliations

1: Clinical and Experimental Pharmacology, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Withington, Manchester M20 4BX, United Kingdom.
2: Institute of Cancer Sciences, University of Manchester, Manchester Academic Health Science Center, The Christie NHS Foundation Trust, Wilmslow Road, Withington, Manchester, M20 4BX, UK.
3: Dept Medical Oncology, University of Manchester and Christie Hospital, Wilmslow Road, Withington, Manchester M20 4BX, UK.
4: Center for Biostatistics, Institute of Population Health, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
5: Bras Family Drug Development Program, Princess Margaret Hospital, 610 University Avenue, Toronto M5G 2M9.
6: MRC Clinical Trials Unit, Aviation House, 125 Kingsway, London WC2B 6NH.
7: Biocartis SA, EPFL-Quartier de l'Innovation, Bâtimont G, CH-1015 Lausanne.
8: Leeds Institute of Cancer and Pathology, St James University Hospital, Leeds LS9 7TF, UK.
9: Translational Angiogenesis Group, University of Manchester and Christie Hospital, Wilmslow Road, Withington, Manchester, M20 4BX, UK.

Associated clinical trials:

Evaluation of the Predictive Value of Blood Levels of Angiopoietin 1 and Endothelial Internal Tunica Cell Kinase 2 in Patients With Ovarian Cancer Treated With Chemotherapy Associated to Bevacizumab | NCT04770376

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