Published in Oxid Med Cell Longev on May 14, 2014
Secret talk between adipose tissue and central nervous system via secreted factors-an emerging frontier in the neurodegenerative research. J Neuroinflammation (2016) 0.86
Reduced flexibility associated with metabolic syndrome in community-dwelling elders. PLoS One (2015) 0.84
Diagnostic Value of Cell-free Circulating MicroRNAs for Obesity and Type 2 Diabetes: A Meta-analysis. J Mol Biomark Diagn (2015) 0.78
Mitochondrial control of cell bioenergetics in Parkinson's disease. Free Radic Biol Med (2016) 0.78
Converging roles of ion channels, calcium, metabolic stress, and activity pattern of Substantia nigra dopaminergic neurons in health and Parkinson's disease. J Neurochem (2016) 0.77
Upregulation of Glutaredoxin-1 Activates Microglia and Promotes Neurodegeneration: Implications for Parkinson's Disease. Antioxid Redox Signal (2016) 0.76
Lardy brains make Parkinson's disease mice worse. J Neurochem (2014) 0.75
Aging of perennial cells and organ parts according to the programmed aging paradigm. Age (Dordr) (2016) 0.75
Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med (2004) 17.79
C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA (2001) 15.85
The spread of the obesity epidemic in the United States, 1991-1998. JAMA (1999) 11.52
Adiposity as compared with physical activity in predicting mortality among women. N Engl J Med (2004) 8.63
Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. Proc Natl Acad Sci U S A (1981) 8.45
Orchestrating the unfolded protein response in health and disease. J Clin Invest (2002) 7.60
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med (2007) 7.27
The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev (2006) 6.80
Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology (1988) 6.79
Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study. BMJ (2005) 5.34
The role of exercise and PGC1alpha in inflammation and chronic disease. Nature (2008) 5.31
An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin. Cell (2001) 4.41
Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat (2005) 4.14
Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity. J Biol Chem (2000) 3.86
Association of coffee and caffeine intake with the risk of Parkinson disease. JAMA (2000) 2.89
Immune function in sport and exercise. J Appl Physiol (1985) (2007) 2.82
Serum vitamin D and the risk of Parkinson disease. Arch Neurol (2010) 2.81
Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress. Toxicol Appl Pharmacol (2006) 2.80
Inflammation as a causative factor in the aetiology of Parkinson's disease. Br J Pharmacol (2007) 2.71
Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects. Brain Res Brain Res Rev (1992) 2.61
CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity. Mol Cell (2002) 2.53
Type 2 diabetes and the risk of Parkinson's disease. Diabetes Care (2007) 2.48
Changes in physical fitness and changes in mortality. Lancet (1998) 2.40
Oral hydrogen water prevents chronic allograft nephropathy in rats. Kidney Int (2009) 2.35
Glucose neurotoxicity. Nat Rev Neurosci (2008) 2.32
Body mass index and the risk of Parkinson disease. Neurology (2006) 2.28
Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochem Biophys Res Commun (2007) 2.27
Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. J Neurosci (2000) 2.21
Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients. Neurosci Lett (1995) 2.19
Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients. Neurosci Lett (1994) 2.17
Reduced risk factors for vascular disorders in Parkinson disease patients: a case-control study. Stroke (2006) 2.11
Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem Biophys Res Commun (2008) 2.04
Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutr Res (2008) 2.02
Vitamin D and neurocognitive dysfunction: preventing "D"ecline? Mol Aspects Med (2008) 2.01
Hypertension, hypercholesterolemia, diabetes, and risk of Parkinson disease. Neurology (2007) 1.97
Oxidative stress in Parkinson's disease: a mechanism of pathogenic and therapeutic significance. Ann N Y Acad Sci (2008) 1.92
Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury. Am J Transplant (2008) 1.86
Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both. J Heart Lung Transplant (2009) 1.78
Multiple pathways of peroxynitrite cytotoxicity. Toxicol Lett (2003) 1.77
The oxidant stress of hyperhomocyst(e)inemia. J Clin Invest (1996) 1.76
Is there anything good in uric acid? QJM (2011) 1.75
Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study. J Clin Biochem Nutr (2010) 1.70
Oxidative stress and programmed cell death in diabetic neuropathy. Ann N Y Acad Sci (2002) 1.67
Hyperhomocyst(e)inemia is a risk factor for arterial endothelial dysfunction in humans. Circulation (1997) 1.67
Recent advances in hydrogen research as a therapeutic medical gas. Free Radic Res (2010) 1.65
Homocysteine-induced endothelial cell injury in vitro: a model for the study of vascular injury. Thromb Res (1980) 1.63
Vitamin D and Parkinson's disease--a hypothesis. Mov Disord (2007) 1.62
Plasma urate and Parkinson's disease in the Atherosclerosis Risk in Communities (ARIC) study. Am J Epidemiol (2009) 1.56
Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice. Neuropsychopharmacology (2008) 1.55
Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice. Cancer Chemother Pharmacol (2009) 1.54
Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease. Neurosci Lett (2009) 1.54
Midlife adiposity and the future risk of Parkinson's disease. Neurology (2002) 1.52
Oxidative-nitrosative stress and poly(ADP-ribose) polymerase (PARP) activation in experimental diabetic neuropathy: the relation is revisited. Diabetes (2005) 1.50
Heat treatment improves glucose tolerance and prevents skeletal muscle insulin resistance in rats fed a high-fat diet. Diabetes (2008) 1.47
Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. PLoS One (2009) 1.46
Caffeine analogs: biomedical impact. Cell Mol Life Sci (2007) 1.41
Exercise and Toll-like receptors. Exerc Immunol Rev (2006) 1.35
Caffeine as an antioxidant: inhibition of lipid peroxidation induced by reactive oxygen species. Biochim Biophys Acta (1996) 1.34
Risk-factors for Parkinson's disease: case-control study in the province of Cáceres, Spain. Acta Neurol Scand (1994) 1.27
Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice. Biochem Biophys Res Commun (2008) 1.24
The role of oxidative stress in the metabolic syndrome. Rev Cardiovasc Med (2011) 1.23
Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation. J Neurosci Res (2008) 1.22
Intake of vitamin E, vitamin C, and carotenoids and the risk of Parkinson's disease: a meta-analysis. Lancet Neurol (2005) 1.20
Current perspective on exercise immunology. Curr Sports Med Rep (2003) 1.18
Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice. Obesity (Silver Spring) (2011) 1.17
S-adenosylmethionine levels in psychiatric and neurological disorders: a review. Acta Neurol Scand Suppl (1994) 1.16
Is physical exercise beneficial for persons with Parkinson's disease? Clin J Sport Med (2006) 1.14
Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury. Invest Ophthalmol Vis Sci (2009) 1.13
Dietary polyphenols protect dopamine neurons from oxidative insults and apoptosis: investigations in primary rat mesencephalic cultures. Biochem Pharmacol (2004) 1.12
Protective effects of resveratrol and quercetin against MPP+ -induced oxidative stress act by modulating markers of apoptotic death in dopaminergic neurons. Cell Mol Neurobiol (2009) 1.12
Mechanisms of high glucose-induced apoptosis and its relationship to diabetic complications. J Nutr Biochem (2005) 1.11
Interleukin-6 levels in cerebrospinal fluid inversely correlate to severity of Parkinson's disease. Acta Neurol Scand (1998) 1.10
Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes. J Neurol Sci (2007) 1.07
Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptor-independent properties. Brain Res (2006) 1.06
Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress. Free Radic Biol Med (2011) 1.05
Dietary antioxidants and Parkinson disease. The Rotterdam Study. Arch Neurol (1997) 1.05
Antioxidants and aging. Am J Clin Nutr (1991) 1.04
Serum uric acid levels in patients with Parkinson's disease: their relationship to treatment and disease duration. Clin Neurol Neurosurg (2009) 1.03
Are the effects of alpha-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract? FEBS Lett (2009) 1.02
Neuroprotective effect of estradiol and phytoestrogens on MPP+-induced cytotoxicity in neuronal PC12 cells. J Neurosci Res (2002) 1.01
Neurodegeneration in an animal model of Parkinson's disease is exacerbated by a high-fat diet. Am J Physiol Regul Integr Comp Physiol (2010) 1.01
Neuroinflammation in Parkinson's disease: is there sufficient evidence for mechanism-based interventional therapy? Front Biosci (2008) 0.98
Enhanced susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in high-fat diet-induced obesity. Free Radic Biol Med (2005) 0.98
Higher serum uric acid associated with decreased Parkinson's disease prevalence in a large community-based survey. Mov Disord (2010) 0.97
Cannabidiol for the treatment of psychosis in Parkinson's disease. J Psychopharmacol (2008) 0.97
Effect of a high-fat diet on 24-hour pattern of circulating adipocytokines in rats. Obesity (Silver Spring) (2009) 0.96
Intersection between metabolic dysfunction, high fat diet consumption, and brain aging. J Neurochem (2010) 0.96
Applications and bioefficacy of the functional food supplement fermented papaya preparation. Toxicology (2010) 0.95
The antioxidant response as a drug target in diabetic neuropathy. Curr Drug Targets (2008) 0.94
Hyperglycemia enhances excessive superoxide anion radical generation, oxidative stress, early inflammation, and endothelial injury in forebrain ischemia/reperfusion rats. Brain Res (2009) 0.94
Urate and its transgenic depletion modulate neuronal vulnerability in a cellular model of Parkinson's disease. PLoS One (2012) 0.93
Exercise therapy for Parkinson's disease. Arch Phys Med Rehabil (1986) 0.93
Biological effects of electrolyzed water in hemodialysis. Nephron Clin Pract (2009) 0.91
Quercetin and sesamin protect neuronal PC12 cells from high-glucose-induced oxidation, nitrosative stress, and apoptosis. Rejuvenation Res (2012) 0.89
Therapeutic value of exercise training in Parkinson's disease. Med Sci Sports Exerc (1999) 0.89
Is homocysteine a pro-oxidant? Free Radic Res (2001) 0.88
Plasma homocysteine and l-dopa metabolism in patients with Parkinson disease. Clin Chem (2001) 0.87
Decreased methionine adenosyltransferase activity in erythrocytes of patients with dementia disorders. Eur Neuropsychopharmacol (1995) 0.80
Akinesia due to catecholamine depletion in mice is prevented by caffeine. Further evidence for an involvement of adenosinergic system in the control of motility. J Pharm Pharmacol (1991) 0.76
Efficacy of Acupuncture in Itch: A Systematic Review and Meta-Analysis of Clinical Randomized Controlled Trials. Evid Based Complement Alternat Med (2015) 0.75