Upregulation of the miR-17-92 cluster and its two paraloga in osteosarcoma - reasons and consequences.

PubWeight™: 0.88‹?›

🔗 View Article (PMC 4063253)

Published in Genes Cancer on April 01, 2014

Authors

Leila Arabi1,2, Joël R Gsponer1, Jan Smida3, Michaela Nathrath3, Valeria Perrina1, Gernot Jundt1,4, Christian Ruiz1, Luca Quagliata1,5, Daniel Baumhoer1,4,5

Author Affiliations

1: Institute of Pathology, University Hospital Basel, Basel, Switzerland.
2: Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
3: Clinical Cooperation Group Osteosarcoma, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg, Germany.
4: Bone Tumor Reference Center at the Institute of Pathology, University Hospital Basel, Basel, Switzerland.
5: Shared senior authorship.

Articles cited by this

Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27

A microRNA polycistron as a potential human oncogene. Nature (2005) 40.21

Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell (2011) 16.72

Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols. J Clin Oncol (2002) 10.03

The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease. Cell Death Differ (2013) 2.41

Neoadjuvant chemotherapy with high-dose Ifosfamide, high-dose methotrexate, cisplatin, and doxorubicin for patients with localized osteosarcoma of the extremity: a joint study by the Italian and Scandinavian Sarcoma Groups. J Clin Oncol (2005) 2.17

Modulation of the osteosarcoma expression phenotype by microRNAs. PLoS One (2012) 2.06

miR-20a encoded by the miR-17-92 cluster increases the metastatic potential of osteosarcoma cells by regulating Fas expression. Cancer Res (2011) 2.06

New molecular insights into osteosarcoma targeted therapy. Curr Opin Oncol (2013) 1.97

mir-17-92: a polycistronic oncomir with pleiotropic functions. Immunol Rev (2013) 1.32

Loss of heterozygosity of the RB gene is a poor prognostic factor in patients with osteosarcoma. J Clin Oncol (1996) 1.26

Genomic alterations and allelic imbalances are strong prognostic predictors in osteosarcoma. Clin Cancer Res (2010) 1.25

Cancer genomes evolve by pulverizing single chromosomes. Cell (2011) 1.20

miR-92a family and their target genes in tumorigenesis and metastasis. Exp Cell Res (2014) 1.13

Feud or Friend? The Role of the miR-17-92 Cluster in Tumorigenesis. Curr Genomics (2010) 1.09

MicroRNA profiling with correlation to gene expression revealed the oncogenic miR-17-92 cluster to be up-regulated in osteosarcoma. Cancer Genet (2012) 1.08

Involvement of the retinoblastoma gene in primary osteosarcomas and other bone and soft-tissue tumors. Clin Orthop Relat Res (1991) 1.05

miR-106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS. Mol Carcinog (2012) 1.01

Biomarkers in Osteosarcoma. Expert Opin Med Diagn (2009) 0.97

MicroRNA-17-92 cluster regulates osteoblast proliferation and differentiation. Endocrine (2013) 0.96

MicroRNA-17-92a upregulation by estrogen leads to Bim targeting and inhibition of osteoblast apoptosis. J Cell Sci (2012) 0.91

microRNA-17~92 is a powerful cancer driver and a therapeutic target. Cell Cycle (2014) 0.89