Immunohistochemical characterization of cyclin dependent kinase-4 in different histological grades of oral leukoplakia and oral squamous cell carcinoma.

PubWeight™: 0.75‹?›

🔗 View Article (PMC 4065445)

Published in J Oral Maxillofac Pathol on January 01, 2014

Authors

Ndvn Shyam1, Nirmala N Rao2, Raman Ds Narang3, Jiji George4, Sanjay R Bommu5, G Kiran1

Author Affiliations

1: Department of Oral and Maxillofacial Pathology, Government Dental College and Hospital, Hyderabad, Andhra Pradesh, India.
2: Department of Oral and Maxillofacial Pathology, Manipal College of Dental Sciences, Manipal, Karnataka, India.
3: Department of Oral and Maxillofacial Pathology, SGRD Institute of Dental Sciences and Research, Amritsar, Punjab, India.
4: Department of Oral and Maxillofacial Pathology, BBD College of Dental Sciences, Lucknow, Uttar Pradesh, India.
5: Department of Oral and Maxillofacial Pathology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA.

Articles cited by this

High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma. Cancer Res (1996) 3.18

Oral white lesions with special reference to precancerous and tobacco- related lesions: conclusions of an international symposium held in Uppsala, Sweden, May 18-21 1994. International Collaborative Group on Oral White Lesions. J Oral Pathol Med (1996) 2.29

Molecular biology of squamous cell carcinoma of the head and neck. J Clin Pathol (2006) 1.76

Gene amplification and overexpression of CDK4 in sporadic breast carcinomas is associated with high tumor cell proliferation. Am J Pathol (1999) 1.41

A comparison of two immunoperoxidase staining methods based on the avidin-biotin interaction. Diagn Immunol (1984) 1.31

Immunohistochemical detection of the cyclin-dependent kinase inhibitor 2/multiple tumor suppressor gene 1 (CDKN2/MTS1) product p16INK4A in archival human solid tumors: correlation with retinoblastoma protein expression. Cancer Res (1995) 1.28

Induction of S phase by G1 regulatory factors. Front Biosci (1999) 1.15

Enhanced malignant tumorigenesis in Cdk4 transgenic mice. Oncogene (2004) 1.15

MTS1/CDK4I is altered in cell lines derived from primary and metastatic oral squamous cell carcinoma. Carcinogenesis (1994) 1.10

Increased expression of cyclin-dependent kinase inhibitor 2 (CDKN2A) gene product P16INK4A in ovarian cancer is associated with progression and unfavourable prognosis. Int J Cancer (1997) 1.02

Deregulated expression of cyclin D1 and other cell cycle-related genes in carcinogen-induced rat mammary tumors. Carcinogenesis (1995) 1.00

Alteration in the expression of cdk4 and cdk6 proteins in oral cancer and premalignant lesions. J Oral Pathol Med (2010) 0.99

Immunohistochemical detection of CDK4 and p16INK4 proteins in cutaneous malignant melanoma. Br J Dermatol (1996) 0.96

Overexpression of cdk4/cyclin D1, a possible mediator of apoptosis and an indicator of prognosis in human primary lung carcinoma. Int J Cancer (2004) 0.91

Aberrations in the MTS1 tumor suppressor locus in oral squamous cell carcinoma lines preferentially affect the INK4A gene and result in increased cdk6 activity. Oral Oncol (2002) 0.91

Expression of p16 and CDK4 in oral premalignant lesions and oral squamous cell carcinomas: a semi-quantitative immunohistochemical study. J Oral Pathol Med (1999) 0.90

Alteration of pRb expression in the development of rat tongue carcinoma induced by 4-nitroquinoline 1-oxide. Oral Oncol (2001) 0.90

Amplification of the CDK4 gene in sarcomas: tumor specificity and relationship with the RB gene mutation. Anticancer Res (1998) 0.90

Alterations of p53, pRb, cyclin D(1) and cdk4 in human oral and pharyngeal squamous cell carcinomas. Oral Oncol (2000) 0.89

Altered expression and activity of G1/S cyclins and cyclin-dependent kinases characterize squamous cell carcinomas of the head and neck. Int J Cancer (1997) 0.88

Immunohistochemical analysis of the expression of cdk4 and p16INK4 in human endometrioid-type endometrial carcinoma. Cancer (1997) 0.86

Alterations of p16/CDKN2, p53 and ras genes in oral squamous cell carcinomas and premalignant lesions. J Oral Pathol Med (1996) 0.85

Alterations of tumor suppressor genes and the H-ras oncogene in oral squamous cell carcinoma. J Oral Pathol Med (1996) 0.81

Clinical evaluation of biologically targeted drugs: obstacles and opportunities. Cancer Chemother Pharmacol (1998) 0.81

Orofacial disease: update for the dental clinical team: 3. White lesions. Dent Update (1999) 0.79

[A study on methodology and the criteria for positive immunohistostaining of estrogen and progesterone receptors in paraffin embedded sections of breast cancer]. Zhonghua Bing Li Xue Za Zhi (1996) 0.77

MTS1 gene mutations in archival oral squamous cell carcinomas. J Oral Pathol Med (1996) 0.77