Published in PLoS One on June 24, 2014
Sildenafil increased exercise capacity during hypoxia at low altitudes and at Mount Everest base camp: a randomized, double-blind, placebo-controlled crossover trial. Ann Intern Med (2004) 2.80
Physiological aspects of high-altitude pulmonary edema. J Appl Physiol (1985) (2005) 1.92
Does recombinant human Epo increase exercise capacity by means other than augmenting oxygen transport? J Appl Physiol (1985) (2008) 1.62
Pericyte-mediated regulation of capillary diameter: a component of neurovascular coupling in health and disease. Front Neuroenergetics (2010) 1.59
Physiological adaptation of the cardiovascular system to high altitude. Prog Cardiovasc Dis (2010) 1.49
Con: Hypoxic pulmonary vasoconstriction is not a limiting factor of exercise at high altitude. High Alt Med Biol (2011) 1.45
THE EFFECT OF TRANSFUSIONS OF RED BLOOD CELLS ON THE HYPOXIA TOLERANCE OF NORMAL MEN. Science (1945) 1.41
Dexamethasone improves maximal exercise capacity of individuals susceptible to high altitude pulmonary edema at 4559 m. High Alt Med Biol (2011) 1.41
Pro: Hypoxic pulmonary vasoconstriction is a limiting factor of exercise at high altitude. High Alt Med Biol (2011) 1.41
Effects of arterial oxygen content on peripheral locomotor muscle fatigue. J Appl Physiol (1985) (2006) 1.38
Effect of altitude on the heart and the lungs. Circulation (2007) 1.38
Adenosine contributes to blood flow regulation in the exercising human leg by increasing prostaglandin and nitric oxide formation. Hypertension (2009) 1.28
Maximal and submaximal exercise performance at altitude. Aviat Space Environ Med (1998) 1.20
The effects of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam on arterial blood pH, blood gases, mean arterial blood pressure and heart rate in adult male rats. Lab Anim Sci (1987) 1.17
Toxicity of over-the-counter stimulants. JAMA (1984) 1.17
Substitution of phenylephrine for pseudoephedrine as a nasal decongeststant. An illogical way to control methamphetamine abuse. Br J Clin Pharmacol (2006) 1.17
Sildenafil inhibits altitude-induced hypoxemia and pulmonary hypertension. Am J Respir Crit Care Med (2004) 1.13
Local control of skeletal muscle blood flow during exercise: influence of available oxygen. J Appl Physiol (1985) (2011) 1.11
Peripheral vasodilatation determines cardiac output in exercising humans: insight from atrial pacing. J Physiol (2012) 1.11
New insights in the pathogenesis of high-altitude pulmonary edema. Prog Cardiovasc Dis (2010) 1.11
Endothelin 1: mitogenic activity on pulmonary artery smooth muscle cells and release from hypoxic endothelial cells. Proc Soc Exp Biol Med (1992) 1.08
Systemic ETA receptor antagonism with BQ-123 blocks ET-1 induced forearm vasoconstriction and decreases peripheral vascular resistance in healthy men. Br J Pharmacol (2001) 1.08
Ephedra and ephedrine for weight loss and athletic performance enhancement: clinical efficacy and side effects. Evid Rep Technol Assess (Summ) (2003) 1.07
During hypoxic exercise some vasoconstriction is needed to match O2 delivery with O2 demand at the microcirculatory level. J Physiol (2007) 1.06
Muscle blood flow during locomotory exercise. Exerc Sport Sci Rev (1985) 1.04
The effects of acute dopamine reuptake inhibition on performance. Med Sci Sports Exerc (2008) 1.02
Alterations in cerebral autoregulation and cerebral blood flow velocity during acute hypoxia: rest and exercise. Am J Physiol Heart Circ Physiol (2006) 1.02
Ambrisentan therapy in patients with pulmonary arterial hypertension who discontinued bosentan or sitaxsentan due to liver function test abnormalities. Chest (2008) 1.00
Differences in EDNO contribution to arteriolar diameters at rest and during functional dilation in striated muscle. Am J Physiol (1993) 0.99
Effect of high-altitude exposure in the elderly: the Tenth Mountain Division study. Circulation (1997) 0.99
Central nervous system stimulants and sport practice. Br J Sports Med (2006) 0.95
Role of myogenic response in enhancing autoregulation of flow during sympathetic nerve stimulation. Am J Physiol (1992) 0.95
Catecholamines in plasma and urine at high altitude. J Appl Physiol (1965) 0.95
Regional muscle blood flow capacity and exercise hyperemia in high-intensity trained rats. J Appl Physiol (1985) (1988) 0.93
Pulmonary artery pressure limits exercise capacity at high altitude. Eur Respir J (2010) 0.92
Ephedrine, caffeine and aspirin: safety and efficacy for treatment of human obesity. Int J Obes Relat Metab Disord (1993) 0.91
A review of pulmonary arterial hypertension: role of ambrisentan. Vasc Health Risk Manag (2007) 0.90
Secretion pores in human endothelial cells during acute hypoxia. J Membr Biol (2002) 0.90
Prevention and treatment of high-altitude pulmonary edema. Prog Cardiovasc Dis (2010) 0.90
Endothelin receptor antagonists for the treatment of pulmonary artery hypertension. Life Sci (2012) 0.90
Dynamic cerebral autoregulation during and following acute hypoxia: role of carbon dioxide. J Appl Physiol (1985) (2013) 0.89
Endothelin-1 as a mediator in cardiovascular disease. Clin Exp Pharmacol Physiol (1999) 0.89
Automated measurement of blood flow velocity and direction and hemoglobin oxygen saturation in the rat lung using intravital microscopy. Am J Physiol Lung Cell Mol Physiol (2012) 0.89
Hypoxia has a greater effect than exercise on the redistribution of pulmonary blood flow in swine. J Appl Physiol (1985) (2007) 0.87
Effects of erythrocyte infusion on VO2max at high altitude. J Appl Physiol (1985) (1996) 0.87
Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism. Am J Physiol Lung Cell Mol Physiol (2012) 0.86
Pharmacokinetics and safety of ambrisentan in combination with sildenafil in healthy volunteers. J Clin Pharmacol (2008) 0.86
The sympathomimetic actions of l-ephedrine and d-pseudoephedrine: direct receptor activation or norepinephrine release? Anesth Analg (2003) 0.86
Improvement in lung diffusion by endothelin A receptor blockade at high altitude. J Appl Physiol (1985) (2011) 0.85
Pressor responses to ephedrine are mediated by a direct mechanism in the rat. J Pharmacol Exp Ther (2005) 0.84
Polymerized bovine hemoglobin decreases oxygen delivery during normoxia and acute hypoxia in the rat. Am J Physiol Heart Circ Physiol (2008) 0.84
Cardiotoxicity of Ma Huang/caffeine or ephedrine/caffeine in a rodent model system. Toxicol Pathol (2007) 0.84
Ephedra and its application to sport performance: another concern for the athletic trainer? J Athl Train (2001) 0.83
Caffeine and ephedrine: physiological, metabolic and performance-enhancing effects. Sports Med (2004) 0.83
Ambrisentan reduces pulmonary arterial hypertension but does not stimulate alveolar and vascular development in neonatal rats with hyperoxic lung injury. Am J Physiol Lung Cell Mol Physiol (2013) 0.83
Cessation of diastolic cerebral blood flow velocity: the role of critical closing pressure. Neurocrit Care (2014) 0.82
Short-term hypoxic vasodilation in vivo is mediated by bioactive nitric oxide metabolites, rather than free nitric oxide derived from haemoglobin-mediated nitrite reduction. J Physiol (2014) 0.81
Repeated administration of ephedrine induces behavioral sensitization in rats. Psychopharmacology (Berl) (1998) 0.81
Initial orthostatic hypotension at high altitude. High Alt Med Biol (2010) 0.81
Norepinephrine transporter -3081(A/T) and alpha-2A-adrenergic receptor MspI polymorphisms are associated with cardiovascular side effects of OROS-methylphenidate treatment. J Psychopharmacol (2011) 0.80
Pharmacokinetic determination of ephedrine in Herba Ephedrae and Wu Tou Tang decoctions in rats using ultra performance liquid chromatography tandem mass spectrometry. Xenobiotica (2012) 0.80
Endothelin-a receptor in rat skeletal muscle microvasculature. Microvasc Res (2002) 0.80
The combination of theophylline and endothelin receptor antagonism improves exercise performance of rats under simulated high altitude. J Appl Physiol (1985) (2012) 0.79
Endothelin receptor mediated constriction and dilatation in feline cerebral resistance arterioles in vivo. Eur J Pharmacol (1996) 0.79
Enhanced expression of endothelin-1 and endothelin-converting enzyme-1 in acute hypoxic rat aorta. Histol Histopathol (2002) 0.79
Methylphenidate: established and expanding roles in symptom management. Am J Hosp Palliat Care (2011) 0.78
In vivo and in vitro action of endothelin-1 on goat cerebrovascular bed. Eur J Pharmacol (1998) 0.78
Evaluating the safety of high-altitude travel in patients with adult congenital heart disease. Congenit Heart Dis (2010) 0.77
Endothelium-derived hyperpolarizing factor contributes to hypoxia-induced skeletal muscle vasodilation in humans. Am J Physiol Heart Circ Physiol (2013) 0.77
Effect of nifedipine on endothelin induced contractions of skeletal muscle arterioles of spontaneously hypertensive rats. Microcirc Endothelium Lymphatics (1991) 0.76
Effects of (-)-ephedrine on locomotion, feeding, and nucleus accumbens dopamine in rats. Psychopharmacology (Berl) (1998) 0.76
Endothelin-B receptors in cerebral resistance arterioles and their functional significance after focal cerebral ischemia in cats. J Cereb Blood Flow Metab (1997) 0.76
Con: Rebuttal. High Alt Med Biol (2011) 0.76
Distribution of pulmonary blood flow in conscious resting rats. Respir Physiol (1994) 0.76
Pro: Rebuttal. High Alt Med Biol (2011) 0.76
Effects of endothelin and endothelin receptor antagonism in arteriolar and venolar microcirculation. Vasa (1998) 0.76
Possible association with amphetamine usage and development of high altitude pulmonary edema. Wilderness Environ Med (2012) 0.76
Endothelin-1-induced vasoconstriction does not require intracellular Ca²⁺ waves in arteries from rats exposed to intermittent hypoxia. Am J Physiol Heart Circ Physiol (2014) 0.75
Discriminative stimulus effects of (-)-ephedrine in rats: analysis with catecholamine transporter and receptor ligands. Drug Alcohol Depend (2003) 0.75