Clinical profiling of BCL-2 family members in the setting of BRAF inhibition offers a rationale for targeting de novo resistance using BH3 mimetics.

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Published in PLoS One on July 01, 2014

Authors

Dennie T Frederick1, Roberto A Salas Fragomeni2, Aislyn Schalck3, Isabel Ferreiro-Neira1, Taylor Hoff1, Zachary A Cooper4, Rizwan Haq5, David J Panka6, Lawrence N Kwong4, Michael A Davies4, James C Cusack2, Keith T Flaherty5, David E Fisher7, James W Mier6, Jennifer A Wargo4, Ryan J Sullivan5

Author Affiliations

1: Division of Surgical Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
2: Division of Surgical Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America; Harvard Medical School, Boston, Massachusetts, United States of America.
3: Division of Medical Oncology, Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States of America.
4: Department of Surgical Oncology and Genomic Medicine, University of Texas, M.D.Anderson Cancer Center, Houston, Texas, United States of America.
5: Harvard Medical School, Boston, Massachusetts, United States of America; Division of Medical Oncology, Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States of America.
6: Harvard Medical School, Boston, Massachusetts, United States of America; Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America.
7: Harvard Medical School, Boston, Massachusetts, United States of America; Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.

Associated clinical trials:

A Study of Vemurafenib (RO5185426) in Comparison With Dacarbazine in Previously Untreated Patients With Metastatic Melanoma (BRIM 3) | NCT01006980

Investigate Safety, Pharmacokinetics and Pharmacodynamics of GSK2118436 & GSK1120212 | NCT01072175

A Study of Vemurafenib in Previously Treated Patients With Metastatic Melanoma | NCT00949702

Dabrafenib, Trametinib, and Navitoclax in Treating Patients With BRAF Mutant Melanoma or Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery | NCT01989585

A Study of RO5185426 in Patients With Metastatic Melanoma | NCT01248936

A Pharmacokinetic/Pharmacodynamic Study of RO5185426 in Previously Treated Patients With Metastatic Melanoma | NCT01107418

A Study of the Effect of Food on the Pharmacokinetics of Single Dose RO5185426 And the Safety And Efficacy of Continuous Administration in Patients With BRAF V600E Mutation-Positive Metastatic Melanoma | NCT01264380

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