Published in Acc Chem Res on July 03, 2014
Radical S-adenosylmethionine (SAM) enzymes in cofactor biosynthesis: a treasure trove of complex organic radical rearrangement reactions. J Biol Chem (2014) 0.87
Advanced paramagnetic resonance spectroscopies of iron-sulfur proteins: Electron nuclear double resonance (ENDOR) and electron spin echo envelope modulation (ESEEM). Biochim Biophys Acta (2015) 0.81
Connecting lipoxygenase function to structure by electron paramagnetic resonance. Acc Chem Res (2014) 0.78
N-Substituted Derivatives of the Azadithiolate Cofactor from the [FeFe] Hydrogenases: Stability and Complexation. Inorg Chem (2015) 0.77
Transient intermediates in enzymology, 1964-2008. J Biol Chem (2015) 0.75
Biosynthesis of the [FeFe] Hydrogenase H Cluster: A Central Role for the Radical SAM Enzyme HydG. Inorg Chem (2015) 0.75
Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods. Nucleic Acids Res (2001) 6.49
The Radical SAM Superfamily. Crit Rev Biochem Mol Biol (2008) 4.05
Crystal structure of biotin synthase, an S-adenosylmethionine-dependent radical enzyme. Science (2004) 2.65
The free radical in pyruvate formate-lyase is located on glycine-734. Proc Natl Acad Sci U S A (1992) 2.30
Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism. Proc Natl Acad Sci U S A (2006) 2.16
The HydG enzyme generates an Fe(CO)2(CN) synthon in assembly of the FeFe hydrogenase H-cluster. Science (2014) 1.78
Structural insights into radical generation by the radical SAM superfamily. Chem Rev (2011) 1.77
The x-ray crystal structure of lysine-2,3-aminomutase from Clostridium subterminale. Proc Natl Acad Sci U S A (2005) 1.72
S-adenosylmethionine as an oxidant: the radical SAM superfamily. Trends Biochem Sci (2007) 1.70
Radical S-adenosylmethionine enzymes. Chem Rev (2014) 1.64
Structural basis for methyl transfer by a radical SAM enzyme. Science (2011) 1.61
RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA. J Am Chem Soc (2010) 1.60
ENDOR spectroscopy shows that guanine N1 binds to [4Fe-4S] cluster II of the S-adenosylmethionine-dependent enzyme MoaA: mechanistic implications. J Am Chem Soc (2009) 1.54
[FeFe]-hydrogenase cyanide ligands derived from S-adenosylmethionine-dependent cleavage of tyrosine. Angew Chem Int Ed Engl (2010) 1.51
Coordination and mechanism of reversible cleavage of S-adenosylmethionine by the [4Fe-4S] center in lysine 2,3-aminomutase. J Am Chem Soc (2003) 1.42
Direct FeS cluster involvement in generation of a radical in lysine 2,3-aminomutase. Biochemistry (2000) 1.41
Radical-mediated enzymatic methylation: a tale of two SAMS. Acc Chem Res (2011) 1.33
[FeFe]-hydrogenase maturation: HydG-catalyzed synthesis of carbon monoxide. J Am Chem Soc (2010) 1.33
The role of the maturase HydG in [FeFe]-hydrogenase active site synthesis and assembly. FEBS Lett (2009) 1.26
Closing in on complete pathways of biotin biosynthesis. Mol Biosyst (2011) 1.26
Characterization of an allylic analogue of the 5'-deoxyadenosyl radical: an intermediate in the reaction of lysine 2,3-aminomutase. Biochemistry (2001) 1.17
Role of the [2Fe-2S] cluster in recombinant Escherichia coli biotin synthase. Biochemistry (2004) 1.15
A radical intermediate in tyrosine scission to the CO and CN- ligands of FeFe hydrogenase. Science (2013) 1.15
A consensus mechanism for Radical SAM-dependent dehydrogenation? BtrN contains two [4Fe-4S] clusters. Biochemistry (2010) 1.13
Structure of a substrate radical intermediate in the reaction of lysine 2,3-aminomutase. Biochemistry (1992) 1.12
Cell-free H-cluster synthesis and [FeFe] hydrogenase activation: all five CO and CN⁻ ligands derive from tyrosine. PLoS One (2011) 1.12
Unexpected electron transfer mechanism upon AdoMet cleavage in radical SAM proteins. Proc Natl Acad Sci U S A (2009) 1.12
An organic radical in the lysine 2,3-aminomutase reaction. Biochemistry (1992) 1.07
Structural diversity in the AdoMet radical enzyme superfamily. Biochim Biophys Acta (2012) 1.06
The [4Fe-4S](2+) cluster in reconstituted biotin synthase binds S-adenosyl-L-methionine. J Am Chem Soc (2002) 1.03
Mechanistic study on the reaction of a radical SAM dehydrogenase BtrN by electron paramagnetic resonance spectroscopy. Biochemistry (2008) 1.02
Identification and function of auxiliary iron-sulfur clusters in radical SAM enzymes. Biochim Biophys Acta (2012) 1.02
Lysine 2,3-aminomutase and trans-4,5-dehydrolysine: characterization of an allylic analogue of a substrate-based radical in the catalytic mechanism. Biochemistry (2000) 1.02
The substrate radical of Escherichia coli oxygen-independent coproporphyrinogen III oxidase HemN. J Biol Chem (2006) 1.00
Biotin synthase: insights into radical-mediated carbon-sulfur bond formation. Biochim Biophys Acta (2012) 0.98
How an enzyme tames reactive intermediates: positioning of the active-site components of lysine 2,3-aminomutase during enzymatic turnover as determined by ENDOR spectroscopy. J Am Chem Soc (2006) 0.96
Reaction of AdoMet with ThiC generates a backbone free radical. Biochemistry (2009) 0.96
A substrate radical intermediate in catalysis by the antibiotic resistance protein Cfr. Nat Chem Biol (2013) 0.93
Mechanistic studies of the radical S-adenosyl-L-methionine enzyme DesII: EPR characterization of a radical intermediate generated during its catalyzed dehydrogenation of TDP-D-quinovose. J Am Chem Soc (2011) 0.92
Catalytic activity of the anaerobic tyrosine lyase required for thiamine biosynthesis in Escherichia coli. J Biol Chem (2009) 0.92
Biosynthesis of F0, precursor of the F420 cofactor, requires a unique two radical-SAM domain enzyme and tyrosine as substrate. J Am Chem Soc (2012) 0.90
Pulsed electron paramagnetic resonance studies of the lysine 2,3-aminomutase substrate radical: evidence for participation of pyridoxal 5'-phosphate in a radical rearrangement. Biochemistry (1995) 0.90
Characterization of NocL involved in thiopeptide nocathiacin I biosynthesis: a [4Fe-4S] cluster and the catalysis of a radical S-adenosylmethionine enzyme. J Biol Chem (2011) 0.90
NirJ, a radical SAM family member of the d1 heme biogenesis cluster. FEBS Lett (2010) 0.90
9-Mercaptodethiobiotin is generated as a ligand to the [2Fe-2S]+ cluster during the reaction catalyzed by biotin synthase from Escherichia coli. J Am Chem Soc (2012) 0.89
Glycyl radical activating enzymes: structure, mechanism, and substrate interactions. Arch Biochem Biophys (2014) 0.88
S K-edge XAS and DFT calculations on SAM dependent pyruvate formate-lyase activating enzyme: nature of interaction between the Fe4S4 cluster and SAM and its role in reactivity. J Am Chem Soc (2011) 0.87
14,15N, 13C, 57Fe, and 1,2H Q-band ENDOR study of Fe-S proteins with clusters that have endogenous sulfur ligands. Biochemistry (1992) 0.86
Glutamate 2,3-aminomutase: a new member of the radical SAM superfamily of enzymes. Biochim Biophys Acta (2006) 0.85
Reduction of the [2Fe-2S] cluster accompanies formation of the intermediate 9-mercaptodethiobiotin in Escherichia coli biotin synthase. Biochemistry (2011) 0.85
Regioselectivity in the homolytic cleavage of S-adenosylmethionine. Biochemistry (2010) 0.85
Pyridoxal-5'-phosphate as the catalyst for radical isomerization in reactions of PLP-dependent aminomutases. Biochim Biophys Acta (2011) 0.83
Hydrogen bonds guide the short-lived 5'-deoxyadenosyl radical to the place of action. Angew Chem Int Ed Engl (2012) 0.82
Kinetic characterization of transient free radical intermediates in reaction of lysine 2,3-aminomutase by EPR lineshape analysis. Methods Enzymol (2002) 0.76
The HydG enzyme generates an Fe(CO)2(CN) synthon in assembly of the FeFe hydrogenase H-cluster. Science (2014) 1.78
Synthetic model of the asymmetric [Mn3CaO4] cubane core of the oxygen-evolving complex of photosystem II. Proc Natl Acad Sci U S A (2012) 1.38
Pyrroloquinoline quinone biogenesis: demonstration that PqqE from Klebsiella pneumoniae is a radical S-adenosyl-L-methionine enzyme. Biochemistry (2009) 1.34
Spectroscopic and electronic structure studies of the trinuclear Cu cluster active site of the multicopper oxidase laccase: nature of its coordination unsaturation. J Am Chem Soc (2005) 1.16
A radical intermediate in tyrosine scission to the CO and CN- ligands of FeFe hydrogenase. Science (2013) 1.15
A high-spin iron(IV)-oxo complex supported by a trigonal nonheme pyrrolide platform. J Am Chem Soc (2012) 1.14
New insights into [FeFe] hydrogenase activation and maturase function. PLoS One (2012) 1.14
General and efficient simulation of pulse EPR spectra. Phys Chem Chem Phys (2009) 1.12
Binding of histidine in the (Cys)3(His)1-coordinated [2Fe-2S] cluster of human mitoNEET. J Am Chem Soc (2010) 1.06
Coordination environment of a site-bound metal ion in the hammerhead ribozyme determined by 15N and 2H ESEEM spectroscopy. J Am Chem Soc (2006) 1.05
Metal trafficking for nitrogen fixation: NifQ donates molybdenum to NifEN/NifH for the biosynthesis of the nitrogenase FeMo-cofactor. Proc Natl Acad Sci U S A (2008) 1.02
Characterization of two different five-coordinate soluble guanylate cyclase ferrous-nitrosyl complexes. Biochemistry (2008) 1.01
Multifrequency pulsed electron paramagnetic resonance study of the S2 state of the photosystem II manganese cluster. Inorg Chem (2008) 0.99
Structural analysis of metal ion ligation to nucleotides and nucleic acids using pulsed EPR spectroscopy. J Am Chem Soc (2002) 0.97
Biliverdin reduction by cyanobacterial phycocyanobilin:ferredoxin oxidoreductase (PcyA) proceeds via linear tetrapyrrole radical intermediates. J Am Chem Soc (2004) 0.97
Synthesis and characterization of manganese-doped silicon nanoparticles: bifunctional paramagnetic-optical nanomaterial. J Am Chem Soc (2007) 0.97
Interaction of PqqE and PqqD in the pyrroloquinoline quinone (PQQ) biosynthetic pathway links PqqD to the radical SAM superfamily. Chem Commun (Camb) (2010) 0.95
EPR evidence for Co(IV) species produced during water oxidation at neutral pH. J Am Chem Soc (2010) 0.95
Acetate binding at the photosystem II oxygen evolving complex: an S(2)-state multiline signal ESEEM study. J Am Chem Soc (2002) 0.94
The conformation of P450cam in complex with putidaredoxin is dependent on oxidation state. J Am Chem Soc (2013) 0.94
Manganese binding properties of human calprotectin under conditions of high and low calcium: X-ray crystallographic and advanced electron paramagnetic resonance spectroscopic analysis. J Am Chem Soc (2015) 0.93
Pterin-centered radical as a mechanistic probe of the second step of nitric oxide synthase. J Am Chem Soc (2010) 0.93
EPR spectroscopic characterization of the manganese center and a free radical in the oxalate decarboxylase reaction: identification of a tyrosyl radical during turnover. J Biol Chem (2004) 0.93
Investigation of the calcium-binding site of the oxygen evolving complex of photosystem II using 87Sr ESEEM spectroscopy. J Am Chem Soc (2004) 0.92
NO formation by a catalytically self-sufficient bacterial nitric oxide synthase from Sorangium cellulosum. Proc Natl Acad Sci U S A (2009) 0.92
Probing the coupling between proton and electron transfer in photosystem II core complexes containing a 3-fluorotyrosine. J Am Chem Soc (2009) 0.92
Nitric oxide synthase stabilizes the tetrahydrobiopterin cofactor radical by controlling its protonation state. J Am Chem Soc (2010) 0.92
Mechanism of assembly of the dimanganese-tyrosyl radical cofactor of class Ib ribonucleotide reductase: enzymatic generation of superoxide is required for tyrosine oxidation via a Mn(III)Mn(IV) intermediate. J Am Chem Soc (2013) 0.91
No evidence from FTIR difference spectroscopy that aspartate-342 of the D1 polypeptide ligates a Mn ion that undergoes oxidation during the S0 to S1, S1 to S2, or S2 to S3 transitions in photosystem II. Biochemistry (2007) 0.89
Double electron-electron resonance shows cytochrome P450cam undergoes a conformational change in solution upon binding substrate. Proc Natl Acad Sci U S A (2012) 0.89
9-Mercaptodethiobiotin is generated as a ligand to the [2Fe-2S]+ cluster during the reaction catalyzed by biotin synthase from Escherichia coli. J Am Chem Soc (2012) 0.89
Electrochemical water oxidation with cobalt-based electrocatalysts from pH 0-14: the thermodynamic basis for catalyst structure, stability, and activity. J Am Chem Soc (2011) 0.88
Hydrogen bonding of tryptophan radicals revealed by EPR at 700 GHz. J Am Chem Soc (2011) 0.87
Investigation of the highly active manganese superoxide dismutase from Saccharomyces cerevisiae. J Am Chem Soc (2010) 0.86
Ligation of D1-His332 and D1-Asp170 to the manganese cluster of photosystem II from Synechocystis assessed by multifrequency pulse EPR spectroscopy. Biochemistry (2011) 0.86
Does aspartate 170 of the D1 polypeptide ligate the manganese cluster in photosystem II? An EPR and ESEEM Study. Biochemistry (2003) 0.86
Electronic structure description of a [Co(III)3Co(IV)O4] cluster: a model for the paramagnetic intermediate in cobalt-catalyzed water oxidation. J Am Chem Soc (2011) 0.86
Structure of the biliverdin radical intermediate in phycocyanobilin:ferredoxin oxidoreductase identified by high-field EPR and DFT. J Am Chem Soc (2009) 0.85
Reduction of the [2Fe-2S] cluster accompanies formation of the intermediate 9-mercaptodethiobiotin in Escherichia coli biotin synthase. Biochemistry (2011) 0.85
Effects of pH on the Rieske protein from Thermus thermophilus: a spectroscopic and structural analysis. Biochemistry (2009) 0.85
Glutamate-354 of the CP43 polypeptide interacts with the oxygen-evolving Mn4Ca cluster of photosystem II: a preliminary characterization of the Glu354Gln mutant. Philos Trans R Soc Lond B Biol Sci (2008) 0.84
Role of Oxido Incorporation and Ligand Lability in Expanding Redox Accessibility of Structurally Related Mn4 Clusters. Chem Sci (2013) 0.84
An EPR, ESEEM, structural NMR, and DFT study of a synthetic model for the covalently ring-linked tyrosine-histidine structure in the heme-copper oxidases. J Am Chem Soc (2004) 0.84
Multifrequency electron spin-echo envelope modulation studies of nitrogen ligation to the manganese cluster of photosystem II. Philos Trans R Soc Lond B Biol Sci (2008) 0.84
Infrared and EPR spectroscopic characterization of a Ni(I) species formed by photolysis of a catalytically competent Ni(I)-CO intermediate in the acetyl-CoA synthase reaction. Biochemistry (2010) 0.84
Comparison of two yeast MnSODs: mitochondrial Saccharomyces cerevisiae versus cytosolic Candida albicans. J Am Chem Soc (2011) 0.84
Nuclear resonance vibrational spectroscopy and electron paramagnetic resonance spectroscopy of 57Fe-enriched [FeFe] hydrogenase indicate stepwise assembly of the H-cluster. Biochemistry (2013) 0.82
Multifrequency EPR studies of manganese catalases provide a complete description of proteinaceous nitrogen coordination. J Phys Chem B (2010) 0.82
The cyanide ligands of [FeFe] hydrogenase: pulse EPR studies of (13)C and (15)N-labeled H-cluster. J Am Chem Soc (2014) 0.82
Redox, haem and CO in enzymatic catalysis and regulation. Biochem Soc Trans (2012) 0.82
Evidence that azide occupies the chloride binding site near the manganese cluster in photosystem II. Biochemistry (2005) 0.82
A conserved histidine-aspartate pair is required for exovinyl reduction of biliverdin by a cyanobacterial phycocyanobilin:ferredoxin oxidoreductase. J Biol Chem (2005) 0.81
Engineered mononuclear variants in Bacillus cereus metallo-beta-lactamase BcII are inactive. Biochemistry (2008) 0.81
Model complexes of cobalt-substituted matrix metalloproteinases: tools for inhibitor design. Inorg Chem (2006) 0.81
EPR-ENDOR characterization of (17O, 1H, 2H) water in manganese catalase and its relevance to the oxygen-evolving complex of photosystem II. J Am Chem Soc (2012) 0.80
A redox series of aluminum complexes: characterization of four oxidation states including a ligand biradical state stabilized via exchange coupling. J Am Chem Soc (2011) 0.80
Anomalous reactivity of ceric nitrate in ruthenium "blue dimer"-catalyzed water oxidation. J Am Chem Soc (2012) 0.79
Water counting: quantitating the hydration level of paramagnetic metal ions bound to nucleotides and nucleic acids. RNA (2002) 0.79
13C ENDOR reveals that the D1 polypeptide C-terminus is directly bound to Mn in the photosystem II oxygen evolving complex. J Am Chem Soc (2010) 0.79
Synthesis and characterization of [Ru@Ge12]3-: an endohedral 3-connected cluster. J Am Chem Soc (2014) 0.79
Rates of water exchange for two cobalt(II) heteropolyoxotungstate compounds in aqueous solution. Chemistry (2011) 0.79
Conformationally distinct five-coordinate heme-NO complexes of soluble guanylate cyclase elucidated by multifrequency electron paramagnetic resonance (EPR). Biochemistry (2012) 0.79
Acceptor and donor-side interactions of phenolic inhibitors in Photosystem II. Biochim Biophys Acta (2003) 0.79
The 33 kDa protein can be removed without affecting the association of the 23 and 17 kDa proteins with the luminal side of PS II of spinach. Biochemistry (2006) 0.78
Atomic hydrogen as high-precision field standard for high-field EPR. J Magn Reson (2010) 0.78
Simulations of the (1)H electron spin echo-electron nuclear double resonance and (2)H electron spin echo envelope modulation spectra of exchangeable hydrogen nuclei coupled to the S(2)-state photosystem II manganese cluster. Philos Trans R Soc Lond B Biol Sci (2002) 0.78
Double electron-electron resonance probes Ca²⁺-induced conformational changes and dimerization of recoverin. Biochemistry (2013) 0.78
The role of arginine-127 at the proximal NO-binding site in determining the electronic structure and function of 5-coordinate NO-heme in cytochrome c' of Rhodobacter sphaeroides. Biochemistry (2009) 0.77
A (31) P NMR investigation of the CoPi water-oxidation catalyst. Chemistry (2012) 0.77
The preparation of a phosphorus doped silicon film from phosphorus containing silicon nanoparticles. Chem Commun (Camb) (2006) 0.77
The internal dynamics of mini c TAR DNA probed by electron paramagnetic resonance of nitroxide spin-labels at the lower stem, the loop, and the bulge. Biochemistry (2012) 0.77
Mechanism, decomposition pathway and new evidence for self-healing of manganese oxides as efficient water oxidizing catalysts: new insights. Dalton Trans (2013) 0.77
Mn(II) Binding and Subsequent Oxidation by the Multicopper Oxidase MnxG Investigated by Electron Paramagnetic Resonance Spectroscopy. J Am Chem Soc (2015) 0.77
Protonation of the Hydroperoxo Intermediate of Cytochrome P450 2B4 Is Slower in the Presence of Cytochrome P450 Reductase Than in the Presence of Cytochrome b5. Biochemistry (2016) 0.76
Pulse electron paramagnetic resonance studies of the interaction of methanol with the S2 state of the Mn4O5Ca cluster of photosystem II. Biochemistry (2014) 0.76
High-frequency and -field EPR spectroscopy of tris(2,4-pentanedionato)manganese(III): investigation of solid-state versus solution Jahn-Teller effects. Inorg Chem (2003) 0.76
Structural basis for hydration dynamics in radical stabilization of bilin reductase mutants. Biochemistry (2010) 0.75
Influence of the 33 kDa manganese-stabilizing protein on the structure and substrate accessibility of the oxygen-evolving complex of photosystem II. Biochemistry (2005) 0.75
Mn(II) oxidation by the multicopper oxidase complex Mnx: A binuclear activation mechanism. J Am Chem Soc (2017) 0.75
Mn(II) oxidation by the multicopper oxidase complex Mnx: A coordinated two-stage Mn(II)/(III) and Mn(III)/(IV) mechanism. J Am Chem Soc (2017) 0.75
Biochemical and Spectroscopic Observation of Mn(II) Sequestration from Bacterial Mn(II) Transport Machinery by Calprotectin. J Am Chem Soc (2017) 0.75
Copper Binding Sites in the Manganese-Oxidizing Mnx Protein Complex Investigated by Electron Paramagnetic Resonance Spectroscopy. J Am Chem Soc (2017) 0.75
Solid-state (55)Mn NMR spectroscopy of bis(μ-oxo)dimanganese(IV) [Mn(2)O(2)(salpn)(2)], a model for the oxygen evolving complex in photosystem II. J Am Chem Soc (2010) 0.75
Metal ion oxidation state assignment based on coordinating ligand hyperfine interaction. Photosynth Res (2015) 0.75
Formation of MgO-supported manganese carbonyl complexes by chemisorption of Mn(CO)5CH3. Langmuir (2013) 0.75
Probing defect sites on TiO2 with [Re3(CO)12H3]: spectroscopic characterization of the surface species. Chemistry (2008) 0.75
Reduction of terphenyl iron(II) or cobalt(II) halides in the presence of trimethylphosphine: an unusual triple dehydrogenation of an alkyl group. Dalton Trans (2009) 0.75
Electron paramagnetic resonance analysis of a transient species formed during water oxidation catalyzed by the complex ion [(bpy)2Ru(OH2)]2O(4+). Inorg Chem (2013) 0.75