Published in Circulation on April 28, 2014
Spironolactone for Pulmonary Arterial Hypertension | NCT01712620
Systems medicine: evolution of systems biology from bench to bedside. Wiley Interdiscip Rev Syst Biol Med (2015) 0.83
Elevated pulmonary arterial and systemic plasma aldosterone levels associate with impaired cardiac reserve capacity during exercise in left ventricular systolic heart failure patients: A pilot study. J Heart Lung Transplant (2015) 0.76
A Time- and Compartment-Specific Activation of Lung Macrophages in Hypoxic Pulmonary Hypertension. J Immunol (2017) 0.75
Pulmonary vascular and ventricular dysfunction in the susceptible patient (2015 Grover Conference series). Pulm Circ (2016) 0.75
Transcription factors regulate GPR91-mediated expression of VEGF in hypoxia-induced retinopathy. Sci Rep (2017) 0.75
Involvement Of Vascular Aldosterone Synthase In Phosphate-Induced Osteogenic Transformation Of Vascular Smooth Muscle Cells. Sci Rep (2017) 0.75
Update on novel targets and potential treatment avenues in pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol (2016) 0.75
Oxymatrine inhibits aldosterone-induced rat cardiac fibroblast proliferation and differentiation by attenuating smad-2,-3 and-4 expression: an in vitro study. BMC Complement Altern Med (2016) 0.75
Hypoxia-induced suppression of c-Myc by HIF-2α in human pulmonary endothelial cells attenuates TFAM expression. Cell Signal (2017) 0.75
30 YEARS OF THE MINERALOCORTICOID RECEPTOR: The role of the mineralocorticoid receptor in the vasculature. J Endocrinol (2017) 0.75
MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2. Cell Metab (2009) 3.30
Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies. Circulation (2010) 2.85
Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage. Am J Pathol (2006) 2.70
Dysregulated renin-angiotensin-aldosterone system contributes to pulmonary arterial hypertension. Am J Respir Crit Care Med (2012) 2.52
Formation of plexiform lesions in experimental severe pulmonary arterial hypertension. Circulation (2010) 2.43
Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity. Nat Med (2007) 2.23
Myofibroblast-mediated mechanisms of pathological remodelling of the heart. Nat Rev Cardiol (2012) 2.03
MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach. Circulation (2012) 1.75
The proto-oncogene c-Fos transcriptionally regulates VEGF production during peritoneal inflammation. Kidney Int (2013) 1.54
CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis. Fibrogenesis Tissue Repair (2012) 1.49
Human steroidogenic acute regulatory protein: functional activity in COS-1 cells, tissue-specific expression, and mapping of the structural gene to 8p11.2 and a pseudogene to chromosome 13. Proc Natl Acad Sci U S A (1995) 1.44
Hypoxia increases AP-1 binding activity by enhancing capacitative Ca2+ entry in human pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol (2003) 1.35
Aldosterone inactivates the endothelin-B receptor via a cysteinyl thiol redox switch to decrease pulmonary endothelial nitric oxide levels and modulate pulmonary arterial hypertension. Circulation (2012) 1.27
Aldosterone-induced activation of signaling pathways requires activity of angiotensin type 1a receptors. Circ Res (2009) 1.17
Angiotensin receptor blockade attenuates cigarette smoke-induced lung injury and rescues lung architecture in mice. J Clin Invest (2011) 1.17
Transdifferentiation of pulmonary arteriolar endothelial cells into smooth muscle-like cells regulated by myocardin involved in hypoxia-induced pulmonary vascular remodelling. Int J Exp Pathol (2006) 1.14
New trial designs and potential therapies for pulmonary artery hypertension. J Am Coll Cardiol (2013) 1.08
Plasma aldosterone levels are elevated in patients with pulmonary arterial hypertension in the absence of left ventricular heart failure: a pilot study. Eur J Heart Fail (2012) 1.04
Mineralocorticoid receptor antagonism attenuates experimental pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol (2013) 0.99
Standardized LC-MS/MS based steroid hormone profile-analysis. J Steroid Biochem Mol Biol (2011) 0.97
Normobaric hypoxia stimulates endothelin-1 gene expression in the rat. Am J Physiol (1992) 0.97
Oxysterols regulate expression of the steroidogenic acute regulatory protein. J Mol Endocrinol (2004) 0.97
Mechanisms of action of hormone-sensitive lipase in mouse Leydig cells: its role in the regulation of the steroidogenic acute regulatory protein. J Biol Chem (2013) 0.95
Steroidogenic factor-1 influences protein-deoxyribonucleic acid interactions within the cyclic adenosine 3,5-monophosphate-responsive regions of the murine steroidogenic acute regulatory protein gene. Endocrinology (2000) 0.93
Regulation of aldosterone synthase in human vascular endothelial cells by angiotensin II and adrenocorticotropin. J Clin Endocrinol Metab (1996) 0.93
Involvement of the bone morphogenetic protein system in endothelin- and aldosterone-induced cell proliferation of pulmonary arterial smooth muscle cells isolated from human patients with pulmonary arterial hypertension. Hypertens Res (2010) 0.90
Interferon-γ promotes vascular remodeling in human microvascular endothelial cells by upregulating endothelin (ET)-1 and transforming growth factor (TGF) β2. J Cell Physiol (2013) 0.89
Transcriptional repression of the rat steroidogenic acute regulatory (StAR) protein gene by the AP-1 family member c-Fos. Mol Cell Endocrinol (2002) 0.89
Do human vascular endothelial cells produce aldosterone? Endocrinology (2004) 0.88
Is captopril effective in primary pulmonary hypertension? Jpn Circ J (1982) 0.87
Effectiveness of spironolactone plus ambrisentan for treatment of pulmonary arterial hypertension (from the [ARIES] study 1 and 2 trials). Am J Cardiol (2013) 0.86
Angiotensin II-aldosterone interaction in human coronary microarteries involves GPR30, EGFR, and endothelial NO synthase. Cardiovasc Res (2012) 0.86
Hypoxia in vivo inhibits aldosterone synthesis and aldosterone synthase mRNA in rats. J Appl Physiol (1985) (1996) 0.85
Spironolactone attenuates bleomycin-induced pulmonary injury partially via modulating mononuclear phagocyte phenotype switching in circulating and alveolar compartments. PLoS One (2013) 0.83
Non-adrenal synthesis of aldosterone: a reality check. Mol Cell Endocrinol (2011) 0.83
c-Fos mediates angiotensin II-induced aldosterone production and protein synthesis in bovine adrenal glomerulosa cells. Endocrinology (2008) 0.83
The role of hypoxia in pulmonary vascular diseases: a perspective. Am J Physiol Lung Cell Mol Physiol (2013) 0.83
Interactions among vascular-tone modulators contribute to high altitude pulmonary edema and augmented vasoreactivity in highlanders. PLoS One (2012) 0.81
Low oxygen selectively inhibits aldosterone secretion from bovine adrenocortical cells in vitro. Am J Physiol (1989) 0.80
Identification of a novel distal control region upstream of the human steroidogenic acute regulatory protein (StAR) gene that participates in SF-1-dependent chromatin architecture. J Biol Chem (2010) 0.80
Role of aldosterone on lung structural remodelling and right ventricular function in congestive heart failure. BMC Cardiovasc Disord (2011) 0.80
Steroidogenesis in isolated adrenocortical cells during development in rats. Mol Cell Endocrinol (1993) 0.78
Effect of exposure to hypoxia from birth on aldosterone in rabbits: role of unesterified fatty acids. Am J Physiol (1997) 0.77
O2 dependence of pregnenolone and aldosterone synthesis in mitochondria from bovine zona glomerulosa cells. J Appl Physiol (1985) (1995) 0.76