Published in PLoS Genet on July 10, 2014
Chromatin-Remodeling-Factor ARID1B Represses Wnt/β-Catenin Signaling. Am J Hum Genet (2015) 0.83
Emerging Molecular and Biological Functions of MBD2, a Reader of DNA Methylation. Front Genet (2016) 0.80
The chromatin-remodeling enzyme BRG1 promotes colon cancer progression via positive regulation of WNT3A. Oncotarget (2016) 0.75
Suppression of intestinal tumors by targeting the mitotic spindle of intestinal stem cells. Oncogene (2016) 0.75
Cdx2 Regulates Gene Expression Through the Recruitment of Brg1-Associated SWI/SNF Chromatin Remodeling Activity. J Biol Chem (2017) 0.75
Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature (2007) 29.32
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature (2009) 19.18
Crypt stem cells as the cells-of-origin of intestinal cancer. Nature (2008) 11.66
Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol Cell Biol (2002) 10.95
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature (2010) 10.60
A restricted cell population propagates glioblastoma growth after chemotherapy. Nature (2012) 8.88
Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell (2002) 8.08
Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta (2003) 7.85
Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis (2004) 6.83
BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription. Nature (1993) 6.41
beadarray: R classes and methods for Illumina bead-based data. Bioinformatics (2007) 6.08
Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev (2004) 5.66
Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model. Cancer Cell (2009) 4.82
The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. Cell Stem Cell (2011) 4.79
Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science (1997) 4.62
Telomerase modulates Wnt signalling by association with target gene chromatin. Nature (2009) 3.96
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers. EMBO J (2012) 3.70
OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells. Gastroenterology (2009) 3.39
BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines. Cancer Res (2000) 3.01
The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation. EMBO J (2001) 2.87
ROAST: rotation gene set tests for complex microarray experiments. Bioinformatics (2010) 2.86
Epigenetics in cancer: targeting chromatin modifications. Mol Cancer Ther (2009) 2.50
Loss of BRG1/BRM in human lung cancer cell lines and primary lung cancers: correlation with poor prognosis. Cancer Res (2003) 2.28
SNF2beta-BRG1 is essential for the viability of F9 murine embryonal carcinoma cells. Mol Cell Biol (1997) 2.14
The BRG1 transcriptional coregulator. Nucl Recept Signal (2008) 2.00
Genomic loss of miR-486 regulates tumor progression and the OLFM4 antiapoptotic factor in gastric cancer. Clin Cancer Res (2011) 1.86
Oncogenesis caused by loss of the SNF5 tumor suppressor is dependent on activity of BRG1, the ATPase of the SWI/SNF chromatin remodeling complex. Cancer Res (2009) 1.82
The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis. PLoS Biol (2010) 1.81
Characterization of mammary tumors from Brg1 heterozygous mice. Oncogene (2007) 1.70
Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation. Nat Genet (2008) 1.50
Elimination of background recombination: somatic induction of Cre by combined transcriptional regulation and hormone binding affinity. Nucleic Acids Res (2004) 1.43
Genetic and epigenetic screening for gene alterations of the chromatin-remodeling factor, SMARCA4/BRG1, in lung tumors. Genes Chromosomes Cancer (2004) 1.27
Targeted knockout of BRG1 potentiates lung cancer development. Cancer Res (2008) 1.24
The chromatin-remodeling enzyme BRG1 modulates vascular Wnt signaling at two levels. Proc Natl Acad Sci U S A (2011) 1.21
Achaete-scute like 2 (ascl2) is a target of Wnt signalling and is upregulated in intestinal neoplasia. Oncogene (2006) 1.17
A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts. Gut (2012) 1.16
Targeting the WNT/beta-catenin/TCF/LEF1 axis in solid and haematological cancers: Multiplicity of therapeutic options. Eur J Cancer (2009) 1.12
The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a. Mol Cancer (2009) 1.06
Critical role of Brg1 member of the SWI/SNF chromatin remodeling complex during neurogenesis and neural crest induction in zebrafish. Dev Dyn (2006) 1.06
Olfactomedin 4, a novel marker for the differentiation and progression of gastrointestinal cancers. Neoplasma (2011) 1.05
Deficiency of Mbd2 attenuates Wnt signaling. Mol Cell Biol (2008) 0.97
Depletion of OLFM4 gene inhibits cell growth and increases sensitization to hydrogen peroxide and tumor necrosis factor-alpha induced-apoptosis in gastric cancer cells. J Biomed Sci (2012) 0.86
Brg1 is required for stem cell maintenance in the murine intestinal epithelium in a tissue-specific manner. Stem Cells (2013) 0.83
Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine. PLoS One (2009) 1.18
Brg1 is required for stem cell maintenance in the murine intestinal epithelium in a tissue-specific manner. Stem Cells (2013) 0.83
Assessment of the In Vivo Activity of PI3K and MEK Inhibitors in Genetically Defined Models of Colorectal Cancer. Mol Cancer Ther (2015) 0.78