Hierarchical cascades of instability govern the mechanics of coiled coils: helix unfolding precedes coil unzipping.

PubWeight™: 0.75‹?›

🔗 View Article (PMC 4104036)

Published in Biophys J on July 15, 2014

Authors

Elham Hamed1, Sinan Keten2

Author Affiliations

1: Department of Civil and Environmental Engineering and Department of Mechanical Engineering, Northwestern University, Evanston, Illinois.
2: Department of Civil and Environmental Engineering and Department of Mechanical Engineering, Northwestern University, Evanston, Illinois. Electronic address: s-keten@northwestern.edu.

Articles cited by this

Scalable molecular dynamics with NAMD. J Comput Chem (2005) 59.49

All-atom empirical potential for molecular modeling and dynamics studies of proteins. J Phys Chem B (1998) 54.00

Predicting coiled coils from protein sequences. Science (1991) 38.18

Design of a novel globular protein fold with atomic-level accuracy. Science (2003) 13.06

X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil. Science (1991) 10.81

Toward high-resolution de novo structure prediction for small proteins. Science (2005) 9.18

Mechanisms of viral membrane fusion and its inhibition. Annu Rev Biochem (2001) 8.96

Coiled coils: new structures and new functions. Trends Biochem Sci (1996) 8.63

Escaping free-energy minima. Proc Natl Acad Sci U S A (2002) 7.98

Coiled coils: a highly versatile protein folding motif. Trends Cell Biol (2001) 5.55

Unfolding of titin immunoglobulin domains by steered molecular dynamics simulation. Biophys J (1998) 5.01

Selection of peptides with semiconductor binding specificity for directed nanocrystal assembly. Nature (2000) 4.57

The structure of alpha-helical coiled coils. Adv Protein Chem (2005) 3.99

A computationally directed screen identifying interacting coiled coils from Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2000) 3.92

The design of coiled-coil structures and assemblies. Adv Protein Chem (2005) 2.87

Dynamics and folding of single two-stranded coiled-coil peptides studied by fluorescent energy transfer confocal microscopy. Proc Natl Acad Sci U S A (2000) 2.75

The myosin coiled-coil is a truly elastic protein structure. Nat Mater (2002) 2.38

Transcription factors 1: bZIP proteins. Protein Profile (1995) 1.90

Alpha-helical coiled coils: more facts and better predictions. Science (1994) 1.86

Probing the folding mechanism of a leucine zipper peptide by stopped-flow circular dichroism spectroscopy. Biochemistry (1995) 1.78

Structure of the molecular chaperone prefoldin: unique interaction of multiple coiled coil tentacles with unfolded proteins. Cell (2000) 1.74

The role of helix formation in the folding of a fully alpha-helical coiled coil. Proteins (1996) 1.58

Transition state heterogeneity in GCN4 coiled coil folding studied by using multisite mutations and crosslinking. Proc Natl Acad Sci U S A (1999) 1.51

Hierarchical structure controls nanomechanical properties of vimentin intermediate filaments. PLoS One (2009) 1.49

Kinetics of folding of leucine zipper domains. Biochemistry (1995) 1.47

Alpha-helical protein assembly motifs. J Biol Chem (1997) 1.46

The crystal structure of the designed trimeric coiled coil coil-VaLd: implications for engineering crystals and supramolecular assemblies. Protein Sci (1997) 1.42

Thermodynamic analysis of a designed three-stranded coiled coil. Biochemistry (1996) 1.31

Stably folded de novo proteins from a designed combinatorial library. Protein Sci (2003) 1.29

Boehringer Mannheim award lecture 1995. La conference Boehringer Mannheim 1995. De novo design of alpha-helical proteins: basic research to medical applications. Biochem Cell Biol (1996) 1.28

Exploring folding free energy landscapes using computational protein design. Curr Opin Struct Biol (2004) 1.27

Protein- and peptide-modified synthetic polymeric biomaterials. Biopolymers (2010) 1.26

Preformed secondary structure drives the association reaction of GCN4-p1, a model coiled-coil system. J Mol Biol (2000) 1.23

Prospects for de novo phasing with de novo protein models. Acta Crystallogr D Biol Crystallogr (2009) 1.22

Thermal unfolding in a GCN4-like leucine zipper: 13C alpha NMR chemical shifts and local unfolding curves. Biophys J (1997) 1.17

Coiled coils: attractive protein folding motifs for the fabrication of self-assembled, responsive and bioactive materials. Chem Soc Rev (2010) 1.17

Helix packing in proteins: prediction and energetic analysis of dimeric, trimeric, and tetrameric GCN4 coiled coil structures. Proteins (1994) 1.14

Structure and dynamics of de novo proteins from a designed superfamily of 4-helix bundles. Protein Sci (2008) 1.08

Single-molecule dynamics of mechanical coiled-coil unzipping. Langmuir (2007) 1.04

Successful prediction of the coiled coil geometry of the GCN4 leucine zipper domain by simulated annealing: comparison to the X-ray structure. Proteins (1993) 1.04

Solution NMR structure of a designed metalloprotein and complementary molecular dynamics refinement. Structure (2008) 1.03

Observation via one-dimensional 13Calpha NMR of local conformational substates in thermal unfolding equilibria of a synthetic analog of the GCN4 leucine zipper. Proc Natl Acad Sci U S A (1996) 1.03

Coiled-coil based drug-free macromolecular therapeutics: in vivo efficacy. J Control Release (2011) 1.00

New design of helix bundle peptide-polymer conjugates. Biomacromolecules (2008) 1.00

Single molecule unzipping of coiled coils: sequence resolved stability profiles. Phys Rev Lett (2006) 1.00

Coiled-coils: stability, specificity, and drug delivery potential. Adv Drug Deliv Rev (2002) 0.98

Site-specific thermodynamics and kinetics of a coiled-coil transition by spin inversion transfer NMR. Biophys J (1998) 0.98

Genetically engineered block copolymers: influence of the length and structure of the coiled-coil blocks on hydrogel self-assembly. Pharm Res (2007) 0.98

Use of a heterodimeric coiled-coil system for biosensor application and affinity purification. J Chromatogr B Biomed Sci Appl (1998) 0.96

Single molecule mechanics of the kinesin neck. Proc Natl Acad Sci U S A (2009) 0.94

Peptide-based and polypeptide-based hydrogels for drug delivery and tissue engineering. Top Curr Chem (2012) 0.92

Macromolecule-induced assembly of coiled-coils in alternating multiblock polymers. Biomacromolecules (2009) 0.92

Incorporation of designed extended chromophores into amphiphilic 4-helix bundle peptides for nonlinear optical biomolecular materials. Nano Lett (2006) 0.92

Designing heterodimeric two-stranded alpha-helical coiled-coils: the effect of chain length on protein folding, stability and specificity. J Pept Res (2001) 0.91

Engineering a de novo-designed coiled-coil heterodimerization domain off the rapid detection, purification and characterization of recombinantly expressed peptides and proteins. Protein Eng (1996) 0.91

Temperature dependence of the folding and unfolding kinetics of the GCN4 leucine zipper via 13C(alpha)-NMR. Biophys J (2001) 0.90

Folding of a three-stranded coiled coil. Protein Sci (2000) 0.87

Site-specific experiments on folding/unfolding of Jun coiled coils: thermodynamic and kinetic parameters from spin inversion transfer nuclear magnetic resonance at leucine-18. Biopolymers (2006) 0.87

Structural studies of amphiphilic 4-helix bundle peptides incorporating designed extended chromophores for nonlinear optical biomolecular materials. Nano Lett (2006) 0.86

Mechanical response and conformational amplification in α-helical coiled coils. Biophys J (2010) 0.86

Reorganization free energies for long-range electron transfer in a porphyrin-binding four-helix bundle protein. J Am Chem Soc (2006) 0.86

Coiled-coil intermediate filament stutter instability and molecular unfolding. Comput Methods Biomech Biomed Engin (2011) 0.85

De novo design of Ln(III) coiled coils for imaging applications. J Am Chem Soc (2014) 0.82

Computer modeling of polyleucine-based coiled coil dimers in a realistic membrane environment: insight into helix-helix interactions in membrane proteins. Biochemistry (2004) 0.81

Poly(ethylene glycol) conjugation stabilizes the secondary structure of α-helices by reducing peptide solvent accessible surface area. Biomacromolecules (2013) 0.79

Length-dependent force characteristics of coiled coils. Phys Rev E Stat Nonlin Soft Matter Phys (2009) 0.79

Controlling assembly of helical polypeptides via PEGylation strategies. Soft Matter (2011) 0.77

Directing the self-assembly of supra-biomolecular nanotubes using entropic forces. Soft Matter (2014) 0.76