Molecular recognition of gangliosides and their potential for cancer immunotherapies.

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Published in Front Immunol on July 21, 2014

Authors

Ute Krengel1, Paula A Bousquet1

Author Affiliations

1: Department of Chemistry, University of Oslo , Oslo , Norway.

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Angiogenesis as a therapeutic target. Nature (2005) 11.89

The prioritization of cancer antigens: a national cancer institute pilot project for the acceleration of translational research. Clin Cancer Res (2009) 6.83

CHROMATOGRAPHIC SEPARATION OF HUMAN BRAIN GANGLIOSIDES. J Neurochem (1963) 6.22

A comprehensive pathway map of epidermal growth factor receptor signaling. Mol Syst Biol (2005) 5.68

Molecular machinery for non-vesicular trafficking of ceramide. Nature (2003) 5.19

Autophosphorylation sites on the epidermal growth factor receptor. Nature (1984) 5.11

Breakthrough of the year 2013. Cancer immunotherapy. Science (2013) 5.05

Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation. Science (2002) 4.38

Tumor malignancy defined by aberrant glycosylation and sphingo(glyco)lipid metabolism. Cancer Res (1996) 3.73

A mutation in human CMP-sialic acid hydroxylase occurred after the Homo-Pan divergence. Proc Natl Acad Sci U S A (1998) 3.26

Lectins: Carbohydrate-Specific Proteins That Mediate Cellular Recognition. Chem Rev (1998) 3.22

Crystal structure of cholera toxin B-pentamer bound to receptor GM1 pentasaccharide. Protein Sci (1994) 3.19

Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid. Proc Natl Acad Sci U S A (2003) 3.13

The complex life of simple sphingolipids. EMBO Rep (2004) 3.10

Membrane organization and lipid rafts. Cold Spring Harb Perspect Biol (2011) 2.98

De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway. J Biol Chem (2002) 2.79

GD3, a prominent ganglioside of human melanoma. Detection and characterisation by mouse monoclonal antibody. J Exp Med (1982) 2.74

Lipidomics: coming to grips with lipid diversity. Nat Rev Mol Cell Biol (2010) 2.72

Enhanced insulin sensitivity in mice lacking ganglioside GM3. Proc Natl Acad Sci U S A (2003) 2.56

Structural basis of GM1 ganglioside recognition by simian virus 40. Proc Natl Acad Sci U S A (2008) 2.37

Architecture and membrane interactions of the EGF receptor. Cell (2013) 2.29

Mechanism of uptake and incorporation of the non-human sialic acid N-glycolylneuraminic acid into human cells. J Biol Chem (2004) 2.17

Enhancement of antibody detection in cancer using panel of recombinant tumor-associated antigens. Cancer Epidemiol Biomarkers Prev (2003) 2.14

Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system. Proc Natl Acad Sci U S A (1996) 2.10

The molecular basis for the absence of N-glycolylneuraminic acid in humans. J Biol Chem (1998) 2.07

Molecular arrangements in sphingolipids. Conformation and hydrogen bonding of ceramide and their implication on membrane stability and permeability. Biochim Biophys Acta (1976) 2.06

Combinatorial ganglioside biosynthesis. J Biol Chem (2002) 2.06

A vital role for glycosphingolipid synthesis during development and differentiation. Proc Natl Acad Sci U S A (1999) 2.05

Ganglioside-mediated modulation of cell growth. Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor. J Biol Chem (1986) 2.00

EGF mutant receptor vIII as a molecular target in cancer therapy. Endocr Relat Cancer (2001) 1.97

Crystal structure of the N-terminal domain of sialoadhesin in complex with 3' sialyllactose at 1.85 A resolution. Mol Cell (1998) 1.86

Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance. Proc Natl Acad Sci U S A (2007) 1.79

Monoclonal antibodies to a glycolipid antigen on human neuroblastoma cells. Cancer Res (1985) 1.78

Functional role of glycosphingolipids in cell recognition and signaling. J Biochem (1995) 1.75

Autoantibodies in lung cancer: possibilities for early detection and subsequent cure. Thorax (2007) 1.73

Gangliosides as components of lipid membrane domains. Glycobiology (2006) 1.71

Disialoganglioside GD2 on human neuroblastoma cells: target antigen for monoclonal antibody-mediated cytolysis and suppression of tumor growth. Cancer Res (1987) 1.68

Regulation of human EGF receptor by lipids. Proc Natl Acad Sci U S A (2011) 1.64

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Gangliosides in cell recognition and membrane protein regulation. Curr Opin Struct Biol (2009) 1.57

2.2 A resolution structure analysis of two refined N-acetylneuraminyl-lactose--wheat germ agglutinin isolectin complexes. J Mol Biol (1990) 1.55

N-Glycolylneuraminic acid in human tumours. Biochimie (2001) 1.55

Crystal structure of botulinum neurotoxin type A in complex with the cell surface co-receptor GT1b-insight into the toxin-neuron interaction. PLoS Pathog (2008) 1.54

Sialic acid-specific lectins: occurrence, specificity and function. Cell Mol Life Sci (2006) 1.49

Gangliosides expressed in human breast cancer. Cancer Res (1996) 1.49

From lectin structure to functional glycomics: principles of the sugar code. Trends Biochem Sci (2011) 1.46

Epidermal growth factor receptor tyrosine kinase is modulated by GM3 interaction with N-linked GlcNAc termini of the receptor. Proc Natl Acad Sci U S A (2006) 1.43

Partitioning, diffusion, and ligand binding of raft lipid analogs in model and cellular plasma membranes. Biochim Biophys Acta (2012) 1.42

Cholesterol modulates glycolipid conformation and receptor activity. Nat Chem Biol (2011) 1.41

Anti-N-glycolylneuraminic acid antibodies identified in healthy human serum. Xenotransplantation (2002) 1.40

Disialoganglioside directed immunotherapy of neuroblastoma. Cancer Invest (2007) 1.40

Ganglioside/glycosphingolipid turnover: new concepts. Glycoconj J (2004) 1.39

Microbial recognition of human cell surface glycoconjugates. Curr Opin Struct Biol (2008) 1.36

Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanisms. Eur J Immunol (2003) 1.35

Hypoxic culture induces expression of sialin, a sialic acid transporter, and cancer-associated gangliosides containing non-human sialic acid on human cancer cells. Cancer Res (2006) 1.34

The effect of hydrogen bonds on the conformation of glycosphingolipids. Methylated and unmethylated cerebroside studied by X-ray single crystal analysis and model calculations. Chem Phys Lipids (1990) 1.31

The hapten structure of a developmentally regulated glycolipid antigen (SSEA-1) isolated from human erythrocytes and adenocarcinoma: a preliminary note. Biochem Biophys Res Commun (1981) 1.31

Biosynthesis and degradation of mammalian glycosphingolipids. Philos Trans R Soc Lond B Biol Sci (2003) 1.29

A specific type of ganglioside as a modulator of insulin-dependent cell growth and insulin receptor tyrosine kinase activity. Possible association of ganglioside-induced inhibition of insulin receptor function and monocytic differentiation induction in HL-60 cells. J Biol Chem (1991) 1.27

Density-dependent recognition of cell surface GM3 by a certain anti-melanoma antibody, and GM3 lactone as a possible immunogen: requirements for tumor-associated antigen and immunogen. J Immunol (1987) 1.27

Interaction of the extracellular domain of the epidermal growth factor receptor with gangliosides. J Biol Chem (2002) 1.26

Regulation of the catalytic activity of the EGF receptor. Curr Opin Struct Biol (2011) 1.26

Antigen of "serum sickness" type of heterophile antibodies in human sera: indentification as gangliosides with N-glycolylneuraminic acid. Biochem Biophys Res Commun (1977) 1.23

Human influenza A virus hemagglutinin distinguishes sialyloligosaccharides in membrane-associated gangliosides as its receptor which mediates the adsorption and fusion processes of virus infection. Specificity for oligosaccharides and sialic acids and the sequence to which sialic acid is attached. J Biol Chem (1986) 1.22

Tissue micro array analysis of ganglioside N-glycolyl GM3 expression and signal transducer and activator of transcription (STAT)-3 activation in relation to dendritic cell infiltration and microvessel density in non-small cell lung cancer. BMC Cancer (2009) 1.20

Molecular recognition of saccharides by proteins. Insights on the origin of the carbohydrate-aromatic interactions. J Am Chem Soc (2005) 1.19

Lipid polymorphisms and membrane shape. Cold Spring Harb Perspect Biol (2011) 1.19

Analysis of cholera toxin-ganglioside interactions by flow cytometry. Biochemistry (2002) 1.19

Characterization of N-glycolylneuraminic acid-containing gangliosides as tumor-associated Hanganutziu-Deicher antigen in human colon cancer. Cancer Res (1985) 1.15

Glycoimmunomics of human cancer: current concepts and future perspectives. Future Oncol (2007) 1.14

Characterization of the Hanganutziu-Deicher (serum-sickness) antigen as gangliosides containing n-glycolylneuraminic acid. Int Arch Allergy Appl Immunol (1978) 1.13

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Membrane rafting: from apical sorting to phase segregation. FEBS Lett (2009) 1.09

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Syngeneic monoclonal antibody against melanoma antigen with interspecies cross-reactivity recognizes GM3, a prominent ganglioside of B16 melanoma. J Biol Chem (1985) 1.03

Unique conformer selection of human growth-regulatory lectin galectin-1 for ganglioside GM1 versus bacterial toxins. Biochemistry (2003) 1.02

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Crystal structures of the staphylococcal toxin SSL5 in complex with sialyl Lewis X reveal a conserved binding site that shares common features with viral and bacterial sialic acid binding proteins. J Mol Biol (2007) 1.02

Suppression of ganglioside GD3 expression in a rat F-11 tumor cell line reduces tumor growth, angiogenesis, and vascular endothelial growth factor production. Cancer Res (2000) 1.01

Making a fitting choice: common aspects of sugar-binding sites in plant and animal lectins. Structure (1997) 1.01

GM2 expression in renal cell carcinoma: potential role in tumor-induced T-cell dysfunction. Cancer Res (2006) 1.00

The localization of gangliosides in neurons of the central nervous system: the use of anti-ganglioside antibodies. Biochim Biophys Acta (1996) 1.00

Occurrence of tumor-associated ganglioside antigens with Hanganutziu-Deicher antigenic activity on human melanomas. Jpn J Cancer Res (1987) 1.00

Specific expression of unusual GM2 ganglioside with Hanganutziu-Deicher antigen activity on human colon cancers. Jpn J Cancer Res (1987) 0.99

Membrane ganglioside enrichment lowers the threshold for vascular endothelial cell angiogenic signaling. Cancer Res (2006) 0.99

Gangliosides expressed by the renal cell carcinoma cell line SK-RC-45 are involved in tumor-induced apoptosis of T cells. Cancer Res (2003) 0.98

Inhibition of human neuroblastoma cell proliferation and EGF receptor phosphorylation by gangliosides GM1, GM3, GD1A and GT1B. Cell Prolif (2002) 0.97

Extension of the GLYCAM06 Biomolecular Force Field to Lipids, Lipid Bilayers and Glycolipids. Mol Simul (2008) 0.97

Atomic-resolution conformational analysis of the GM3 ganglioside in a lipid bilayer and its implications for ganglioside-protein recognition at membrane surfaces. Glycobiology (2008) 0.96

Vascular endothelial growth factor production is stimulated by gangliosides and TGF-beta isoforms in human glioma cells in vitro. Cancer Lett (1996) 0.95

Ganglioside GM3 inhibits VEGF/VEGFR-2-mediated angiogenesis: direct interaction of GM3 with VEGFR-2. Glycobiology (2008) 0.95

Helicobacter pylori and complex gangliosides. Infect Immun (2004) 0.94

Gangliosides of normal and neoplastic human melanocytes. Biochem Biophys Res Commun (1984) 0.94