Published in PLoS One on August 14, 2014
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MatInspector and beyond: promoter analysis based on transcription factor binding sites. Bioinformatics (2005) 11.75
JASPAR 2010: the greatly expanded open-access database of transcription factor binding profiles. Nucleic Acids Res (2009) 9.42
PROMO: detection of known transcription regulatory elements using species-tailored searches. Bioinformatics (2002) 4.74
Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN. Nucleic Acids Res (2003) 4.00
Structure-function-rescue: the diverse nature of common p53 cancer mutants. Oncogene (2007) 2.96
Genetics of hepatocellular tumors. Oncogene (2006) 2.43
The multifunctional roles of the four-and-a-half-LIM only protein FHL2. Cell Mol Life Sci (2006) 1.99
Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes. Proc Natl Acad Sci U S A (1993) 1.95
Cardiac-specific LIM protein FHL2 modifies the hypertrophic response to beta-adrenergic stimulation. Circulation (2001) 1.74
The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleus. EMBO J (2002) 1.72
Molecular cloning and characterization of FHL2, a novel LIM domain protein preferentially expressed in human heart. Gene (1998) 1.40
Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway. J Clin Invest (2009) 1.39
DRAL is a p53-responsive gene whose four and a half LIM domain protein product induces apoptosis. J Cell Biol (2000) 1.21
Insulin-like growth factor-binding protein 5 (IGFBP-5) interacts with a four and a half LIM protein 2 (FHL2). J Biol Chem (2002) 1.20
Focal adhesion kinase interacts with the transcriptional coactivator FHL2 and both are overexpressed in epithelial ovarian cancer. Anticancer Res (2004) 1.12
Possible biomarkers for ionizing radiation exposure in human peripheral blood lymphocytes. Radiat Res (2003) 1.11
Suppression of FHL2 expression induces cell differentiation and inhibits gastric and colon carcinogenesis. Gastroenterology (2006) 1.10
BRCA1 interacts with FHL2 and enhances FHL2 transactivation function. FEBS Lett (2003) 1.02
Cooperation of tumor-derived HBx mutants and p53-249(ser) mutant in regulating cell proliferation, anchorage-independent growth and aneuploidy in a telomerase-immortalized normal human hepatocyte-derived cell line. Int J Cancer (2010) 1.00
The LIM-only protein FHL2 is a negative regulator of E4F1. Oncogene (2006) 0.98
The four-and-a-half-LIM protein 2 (FHL2) is overexpressed in gliomas and associated with oncogenic activities. Glia (2008) 0.97
Four-and-a-half LIM protein 2 promotes invasive potential and epithelial-mesenchymal transition in colon cancer. Carcinogenesis (2010) 0.96
The biological relevance of FHL2 in tumour cells and its role as a putative cancer target. Anticancer Res (2007) 0.91
FHL2 silencing reduces Wnt signaling and osteosarcoma tumorigenesis in vitro and in vivo. PLoS One (2013) 0.91
Epithelial expression of FHL2 is negatively associated with metastasis-free and overall survival in colorectal cancer. Br J Cancer (2013) 0.88
249 TP53 mutation has high prevalence and is correlated with larger and poorly differentiated HCC in Brazilian patients. BMC Cancer (2009) 0.88
LIM-only protein FHL2 activates NF-κB signaling in the control of liver regeneration and hepatocarcinogenesis. Mol Cell Biol (2013) 0.87
FHL2 exhibits anti-proliferative and anti-apoptotic activities in liver cancer cells. Cancer Lett (2011) 0.86
The four and a half LIM-only protein 2 regulates liver homeostasis and contributes to carcinogenesis. J Hepatol (2012) 0.84
The LIM-only protein FHL2 regulates interleukin-6 expression through p38 MAPK mediated NF-κB pathway in muscle cells. Cytokine (2012) 0.84
Regulation of the transcriptional coactivator FHL2 licenses activation of the androgen receptor in castrate-resistant prostate cancer. Cancer Res (2013) 0.83
Synergistic repression of estrogen receptor transcriptional activity by FHL2 and Smad4 in breast cancer cells. IUBMB Life (2010) 0.83
The four and a half LIM-only protein 2 (FHL2) activates transforming growth factor β (TGF-β) signaling by regulating ubiquitination of the E3 ligase Arkadia. J Biol Chem (2012) 0.81
FHL2 mediates p53-induced transcriptional activation through a direct association with HIPK2. Biochem Biophys Res Commun (2005) 0.79
Characterization of human FHL2 transcript variants and gene expression regulation in hepatocellular carcinoma. Gene (2011) 0.78