Disruption of prion protein-HOP engagement impairs glioblastoma growth and cognitive decline and improves overall survival.

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Published in Oncogene on August 25, 2014

Authors

M H Lopes1, T G Santos2, B R Rodrigues2, N Queiroz-Hazarbassanov2, I W Cunha3, A P Wasilewska-Sampaio2, B Costa-Silva2, F A Marchi4, L F Bleggi-Torres5, P I Sanematsu6, S H Suzuki6, S M Oba-Shinjo7, S K N Marie7, E Toulmin8, A F Hill8, V R Martins9

Author Affiliations

1: 1] International Research Center, AC Camargo Cancer Center, São Paulo, Brazil [2] Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil [3] National Institute for Translational Neuroscience and National Institute of Oncogenomics (CNPq/MCT/FAPESP), São Paulo, Brazil.
2: 1] International Research Center, AC Camargo Cancer Center, São Paulo, Brazil [2] National Institute for Translational Neuroscience and National Institute of Oncogenomics (CNPq/MCT/FAPESP), São Paulo, Brazil.
3: Department of Pathology, AC Camargo Cancer Center, São Paulo, Brazil.
4: 1] International Research Center, AC Camargo Cancer Center, São Paulo, Brazil [2] National Institute for Translational Neuroscience and National Institute of Oncogenomics (CNPq/MCT/FAPESP), São Paulo, Brazil [3] Inter-institutional Grad Program on Bioinformatics, Institute of Mathematics and Statistics, USP-São Paulo University, São Paulo, Brazil.
5: 1] Department of Pathology, Federal University of Paraná, Curitiba, Brazil [2] Pelé Pequeno Príncipe Research Institute, Curitiba, Brazil.
6: Department of Neurosurgery, AC Camargo Cancer Center, São Paulo, Brazil.
7: Department of Neurology, School of Medicine, University of São Paulo, Brazil.
8: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, VIC, Australia.
9: 1] International Research Center, AC Camargo Cancer Center, São Paulo, Brazil [2] National Institute for Translational Neuroscience and National Institute of Oncogenomics (CNPq/MCT/FAPESP), São Paulo, Brazil [3] Ludwig Institute for Cancer Research, São Paulo, Brazil.

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