Monoclonal antibodies against Vibrio vulnificus RtxA1 elicit protective immunity through distinct mechanisms.

PubWeight™: 0.75‹?›

🔗 View Article (PMC 4249331)

Published in Infect Immun on August 25, 2014

Authors

Tae Hee Lee1, Sun-Shin Cha2, Chang-Seop Lee3, Joon Haeng Rhee4, Kyung Min Chung5

Author Affiliations

1: Department of Microbiology and Immunology, Chonbuk National University Medical School, Jeonju, Jeonbuk, South Korea Institute for Medical Science, Chonbuk National University Medical School, Jeonju, Jeonbuk, South Korea.
2: Marine Biotechnology Research Division, Korea Institute of Ocean Science and Technology, Ansan, South Korea Department of Convergence Study on the Ocean Science and Technology, Ocean Science and Technology School, Korea Maritime and Ocean University, Pusan, South Korea Department of Marine Biotechnology, Korea University of Science and Technology, DaeJeon, South Korea.
3: Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Jeonbuk, South Korea.
4: Department of Microbiology and Clinical Vaccine R&D Center, Chonnam National University Medical School, Gwangju, South Korea.
5: Department of Microbiology and Immunology, Chonbuk National University Medical School, Jeonju, Jeonbuk, South Korea Institute for Medical Science, Chonbuk National University Medical School, Jeonju, Jeonbuk, South Korea kmin@jbnu.ac.kr.

Articles cited by this

Disease caused by a marine Vibrio. Clinical characteristics and epidemiology. N Engl J Med (1979) 10.57

Innate immunity. N Engl J Med (2000) 7.03

Syndromes of Vibrio vulnificus infections. Clinical and epidemiologic features in Florida cases, 1981-1987. Ann Intern Med (1988) 4.11

The epidemiology of Vibrio infections in Florida, 1981-1993. J Infect Dis (1996) 4.05

Distribution and ecology of Vibrio vulnificus and other lactose-fermenting marine vibrios in coastal waters of the southeastern United States. Appl Environ Microbiol (1982) 3.83

Epidemiology and pathogenesis of Vibrio vulnificus. Microbes Infect (2000) 3.10

Vibrio vulnificus: disease and pathogenesis. Infect Immun (2009) 2.83

Experimental pathogenicity and mortality in ligated ileal loop studies of the newly reported halophilic lactose-positive Vibrio sp. Infect Immun (1978) 2.67

The interaction between RTX toxins and target cells. Trends Microbiol (1999) 2.27

Clinical, epidemiological, and microbiological features of Vibrio vulnificus biogroup 3 causing outbreaks of wound infection and bacteraemia in Israel. Israel Vibrio Study Group. Lancet (1999) 2.24

RTX toxins recognize a beta2 integrin on the surface of human target cells. J Biol Chem (1997) 2.12

Molecular Pathogenesis of Vibrio vulnificus. J Microbiol (2005) 2.12

Protection of mice against Vibrio vulnificus disease by vaccination with surface antigen preparations and anti-surface antigen antisera. Infect Immun (1984) 1.95

Antibodies against West Nile Virus nonstructural protein NS1 prevent lethal infection through Fc gamma receptor-dependent and -independent mechanisms. J Virol (2006) 1.91

Vibrio vulnificus from raw oysters. Leading cause of reported deaths from foodborne illness in Florida. J Fla Med Assoc (1993) 1.75

MARTX, multifunctional autoprocessing repeats-in-toxin toxins. Infect Immun (2007) 1.69

Identification and characterization of the Vibrio vulnificus rtxA essential for cytotoxicity in vitro and virulence in mice. J Microbiol (2007) 1.67

Hemochromatosis, iron and septicemia caused by Vibrio vulnificus. Arch Intern Med (1991) 1.65

Vibrio vulnificus RTX toxin kills host cells only after contact of the bacteria with host cells. Cell Microbiol (2007) 1.64

Structure and function of MARTX toxins and other large repetitive RTX proteins. Annu Rev Microbiol (2011) 1.62

A requirement for FcγR in antibody-mediated bacterial toxin neutralization. J Exp Med (2010) 1.58

Capsular types of Vibrio vulnificus: an analysis of strains from clinical and environmental sources. J Infect Dis (1993) 1.47

Evidence that mortality from Vibrio vulnificus infection results from single strains among heterogeneous populations in shellfish. J Clin Microbiol (1997) 1.44

Pathogenesis of infection by clinical and environmental strains of Vibrio vulnificus in iron-dextran-treated mice. Infect Immun (2000) 1.42

Differential expression of Vibrio vulnificus capsular polysaccharide. Infect Immun (1999) 1.36

Vibrio vulnificus rtxA1 gene recombination generates toxin variants with altered potency during intestinal infection. Proc Natl Acad Sci U S A (2011) 1.22

The role of seafood in bacterial foodborne diseases. Microbes Infect (2000) 1.22

Additive function of Vibrio vulnificus MARTX(Vv) and VvhA cytolysins promotes rapid growth and epithelial tissue necrosis during intestinal infection. PLoS Pathog (2012) 1.18

Mechanism of high susceptibility of iron-overloaded mouse to Vibrio vulnificus infection. Microbiol Immunol (2000) 1.13

Survival of Vibrio vulnificus in whole blood from patients with chronic liver diseases: association with phagocytosis by neutrophils and serum ferritin levels. J Infect Dis (1999) 1.13

Domain organization and evolution of multifunctional autoprocessing repeats-in-toxin (MARTX) toxin in Vibrio vulnificus. Appl Environ Microbiol (2010) 1.11

Growth of Vibrio vulnificus in serum from alcoholics: association with high transferrin iron saturation. J Infect Dis (1991) 1.11

RTX cytotoxins recognize beta2 integrin receptors through N-linked oligosaccharides. Proc Natl Acad Sci U S A (2008) 1.10

RTX toxin enhances the survival of Vibrio vulnificus during infection by protecting the organism from phagocytosis. J Infect Dis (2011) 1.10

Neutralizing antibodies to adenylate cyclase toxin promote phagocytosis of Bordetella pertussis by human neutrophils. Infect Immun (2000) 1.09

Vibrio vulnificus RTX toxin plays an important role in the apoptotic death of human intestinal epithelial cells exposed to Vibrio vulnificus. Microbes Infect (2008) 1.06

Neutrophils are essential for containment of Vibrio cholerae to the intestine during the proinflammatory phase of infection. Infect Immun (2012) 1.02

Detection of free-living and plankton-bound vibrios in coastal waters of the Adriatic Sea (Italy) and study of their pathogenicity-associated properties. Environ Microbiol (2006) 1.02

Human CD18 is the functional receptor for Aggregatibacter actinomycetemcomitans leukotoxin. Infect Immun (2007) 0.98

A bacterial RTX toxin causes programmed necrotic cell death through calcium-mediated mitochondrial dysfunction. J Infect Dis (2012) 0.97

RtxA1-induced expression of the small GTPase Rac2 plays a key role in the pathogenicity of Vibrio vulnificus. J Infect Dis (2010) 0.96

Mechanisms underlying Mannheimia haemolytica leukotoxin-induced oncosis and apoptosis of bovine alveolar macrophages. Microb Pathog (2005) 0.96

MARTX of Vibrio vulnificus biotype 2 is a virulence and survival factor. Environ Microbiol (2012) 0.91

Capsular polysaccharide-protein conjugate vaccines of carbotype 1 Vibrio vulnificus: construction, immunogenicity, and protective efficacy in a murine model. Infect Immun (1995) 0.90

Temporal and spatial distribution patterns of potentially pathogenic Vibrio spp. at recreational beaches of the German north sea. Microb Ecol (2013) 0.89

Pasteurella haemolytica leukotoxin induced apoptosis of bovine lymphocytes involves DNA fragmentation. Vet Microbiol (1999) 0.88

Vibrio vulnificus infection: an important cause of septicemia in patients with cirrhosis. South Med J (1997) 0.88

Vibrio vulnificus infection and iron overload. J Am Acad Dermatol (1992) 0.87

The pyrH gene of Vibrio vulnificus is an essential in vivo survival factor. Infect Immun (2007) 0.86

Preclinical immunoprophylactic and immunotherapeutic efficacy of antisera to capsular polysaccharide-tetanus toxoid conjugate vaccines of Vibrio vulnificus. Infect Immun (1996) 0.86

Vibrio vulnificus induces macrophage apoptosis in vitro and in vivo. Infect Immun (2003) 0.86

Vibrio cholerae-induced inflammation in the neonatal mouse cholera model. Infect Immun (2014) 0.85

Vibrio vulnificus damages macrophages during the early phase of infection. Infect Immun (2007) 0.85

The role of RTX toxins in host specificity of animal pathogenic Pasteurellaceae. Vet Microbiol (2011) 0.85

Adenylate cyclase toxin promotes internalisation of integrins and raft components and decreases macrophage adhesion capacity. PLoS One (2011) 0.84

The anti-Pseudomonas aeruginosa antibody Panobacumab is efficacious on acute pneumonia in neutropenic mice and has additive effects with meropenem. PLoS One (2013) 0.84

Vibrio infections and surveillance in Maryland, 2002-2008. Public Health Rep (2013) 0.81

Protection against Vibrio vulnificus infection by active and passive immunization with the C-terminal region of the RtxA1/MARTXVv protein. Vaccine (2013) 0.81

Autoproteolytic activation of bacterial toxins. Toxins (Basel) (2010) 0.79

A recombinant metalloprotease antigen of Vibrio vulnificus elicits protective antibodies in a murine model. Lett Appl Microbiol (2009) 0.77