Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial.

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🔗 View Article (PMID 25163906)

Published in Lancet Oncol on August 19, 2014

Authors

Roger Stupp1, Monika E Hegi2, Thierry Gorlia3, Sara C Erridge4, James Perry5, Yong-Kil Hong6, Kenneth D Aldape7, Benoit Lhermitte2, Torsten Pietsch8, Danica Grujicic9, Joachim Peter Steinbach10, Wolfgang Wick11, Rafał Tarnawski12, Do-Hyun Nam13, Peter Hau14, Astrid Weyerbrock15, Martin J B Taphoorn16, Chiung-Chyi Shen17, Nalini Rao18, László Thurzo19, Ulrich Herrlinger8, Tejpal Gupta20, Rolf-Dieter Kortmann21, Krystyna Adamska22, Catherine McBain23, Alba A Brandes24, Joerg Christian Tonn25, Oliver Schnell25, Thomas Wiegel26, Chae-Yong Kim27, Louis Burt Nabors28, David A Reardon29, Martin J van den Bent30, Christine Hicking31, Andriy Markivskyy31, Martin Picard31, Michael Weller32, European Organisation for Research and Treatment of Cancer (EORTC), Canadian Brain Tumor Consortium, CENTRIC study team

Author Affiliations

1: UniversitätsSpital Zürich, Zurich, Switzerland; Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland. Electronic address: roger.stupp@usz.ch.
2: Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
3: EORTC Headquarters, Brussels, Belgium.
4: Edinburgh Cancer Centre, University of Edinburgh, Edinburgh, UK.
5: Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
6: The Catholic University of Korea, Seoul St Mary's Hospital, Seoul, South Korea.
7: The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
8: Department of Neuropathology, Universität Bonn, Bonn, Germany.
9: Clinic for Neurosurgery, Clinical Center Serbia and Medical Faculty University of Belgrade, Belgrade, Serbia.
10: Klinikum der J W Goethe Universität Frankfurt, Frankfurt, Germany.
11: Heidelberg University Medical Center & German Cancer Research Center, Heidelberg, Germany.
12: Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology Gliwice Branch, Gliwice, Poland.
13: Samsung Medical Center, Sungkyunkwan Univ School of Medicine, Seoul, South Korea.
14: Universitätsklinikum Regensburg, Regensburg, Germany.
15: Universitätsklinikum Freiburg, Freiburg, Germany.
16: Medical Center Haaglanden, The Hague, Netherlands.
17: Taichung Veterans General Hospital, Taichung, Taiwan.
18: Bangalore Institute of Oncology, Bangalore, India.
19: Szegedi Tudományegyetem, Szeged, Hungary.
20: Tata Memorial Centre, Navi Mumbai, India.
21: Universitätsklinikum Leipzig, Leipzig, Germany.
22: Greater Poland Cancer Centre, Poznań, Poland.
23: The Christie NHS FT, Manchester, UK.
24: Bellaria-Maggiore Hospital, AUSL-IRCCS Institute of Neurological Sciences-Bologna, Italy.
25: Klinikum der Universität München, München, Germany.
26: University Hospital Ulm, Ulm, Germany.
27: Seoul National University Bundang Hospital, SNU College of Medicine, Seoul, South Korea.
28: University of Alabama at Birmingham, Birmingham, AL, USA.
29: Dana-Farber Cancer Institute, Boston, MA, USA.
30: Erasmus MC-Cancer Institute, Rotterdam, Netherlands.
31: Merck KGaA, Darmstadt, Germany.
32: UniversitätsSpital Zürich, Zurich, Switzerland.

Associated clinical trials:

Cilengitide, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma and Methylated Gene Promoter Status (CENTRIC) | NCT00689221

TIGER PRO-Active - Daily Activity, Sleep and Neurocognitive Functioning Study | NCT04717739

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