A charged residue in S4 regulates coupling among the activation gate, voltage, and Ca2+ sensors in BK channels.

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Published in J Neurosci on September 10, 2014

Authors

Guohui Zhang1, Huanghe Yang2, Hongwu Liang3, Junqiu Yang3, Jingyi Shi3, Kelli McFarland3, Yihan Chen4, Jianmin Cui5

Author Affiliations

1: Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, Missouri 63130, Department of Pharmacology, Soochow University College of Pharmaceutical Sciences, Suzhou 215123, China.
2: Department of Physiology, University of California at San Francisco, San Francisco, California 94143, and.
3: Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, Missouri 63130.
4: Key Laboratory of Basic Research in Cardiology of the Ministry of Education of China (Tongji University), Shanghai 200120, China.
5: Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, Missouri 63130, Department of Pharmacology, Soochow University College of Pharmaceutical Sciences, Suzhou 215123, China, jcui@wustl.edu.

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