α-1-Antitrypsin (AAT)-modified donor cells suppress GVHD but enhance the GVL effect: a role for mitochondrial bioenergetics.

PubWeight™: 0.78‹?›

🔗 View Article (PMC 4215316)

Published in Blood on September 15, 2014

Authors

A Mario Marcondes1, Ekapun Karoopongse2, Marina Lesnikova2, Daciana Margineantu2, Tobias Welte3, Charles A Dinarello4, David Hockenbery1, Sabina Janciauskiene3, H Joachim Deeg1

Author Affiliations

1: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Division of Oncology, University of Washington, Seattle, WA;
2: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA;
3: Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany;
4: Department of Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; and Department of Medicine, University of Colorado Denver, Aurora, CO.

Articles cited by this

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol (2006) 14.33

Prevention of graft versus host disease by inactivation of host antigen-presenting cells. Science (1999) 6.02

Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages. Nat Immunol (2000) 5.45

An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin. Blood (1996) 4.65

The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. Biochim Biophys Acta (1998) 4.50

Graft-versus-leukemia effects of transplantation and donor lymphocytes. Blood (2008) 3.85

Relation of an interleukin-10 promoter polymorphism to graft-versus-host disease and survival after hematopoietic-cell transplantation. N Engl J Med (2003) 3.57

Interleukin-32: a cytokine and inducer of TNFalpha. Immunity (2005) 3.39

Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1. Circ Res (2008) 3.12

Hematopoietic-cell transplantation at 50. N Engl J Med (2007) 2.98

IL-32, a proinflammatory cytokine in rheumatoid arthritis. Proc Natl Acad Sci U S A (2006) 2.67

Preemptive HMG-CoA reductase inhibition provides graft-versus-host disease protection by Th-2 polarization while sparing graft-versus-leukemia activity. Blood (2007) 2.19

Donor APCs are required for maximal GVHD but not for GVL. Nat Med (2004) 2.18

Regulatory dendritic cells protect mice from murine acute graft-versus-host disease and leukemia relapse. Immunity (2003) 1.97

Prevention of GVHD while sparing GVL effect by targeting Th1 and Th17 transcription factor T-bet and RORγt in mice. Blood (2011) 1.97

TLI and ATG conditioning with low risk of graft-versus-host disease retains antitumor reactions after allogeneic hematopoietic cell transplantation from related and unrelated donors. Blood (2009) 1.89

Alpha1-antitrypsin deficiency. 1: epidemiology of alpha1-antitrypsin deficiency. Thorax (2004) 1.89

Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice. Proc Natl Acad Sci U S A (2008) 1.83

Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantation. Blood (2012) 1.71

Manipulating the bioenergetics of alloreactive T cells causes their selective apoptosis and arrests graft-versus-host disease. Sci Transl Med (2011) 1.61

alpha1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice. Proc Natl Acad Sci U S A (2008) 1.53

Rapid natural killer cell recovery determines outcome after T-cell-depleted HLA-identical stem cell transplantation in patients with myeloid leukemias but not with acute lymphoblastic leukemia. Leukemia (2007) 1.47

Recipient tumor necrosis factor-alpha and interleukin-10 gene polymorphisms associate with early mortality and acute graft-versus-host disease severity in HLA-matched sibling bone marrow transplants. Blood (1999) 1.46

Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality. Blood (2013) 1.44

Alpha-1-antitrypsin and a broad spectrum metalloprotease inhibitor, RS113456, have similar acute anti-inflammatory effects. Lab Invest (2001) 1.43

The role of alpha 1-antitrypsin deficiency in the pathogenesis of immune disorders. Clin Immunol Immunopathol (1985) 1.39

NCI First International Workshop on The Biology, Prevention, and Treatment of Relapse After Allogeneic Hematopoietic Stem Cell Transplantation: Report from the Committee on the Biology Underlying Recurrence of Malignant Disease following Allogeneic HSCT: Graft-versus-Tumor/Leukemia Reaction. Biol Blood Marrow Transplant (2010) 1.38

A defined donor activating natural killer cell receptor genotype protects against leukemic relapse after related HLA-identical hematopoietic stem cell transplantation. Leukemia (2005) 1.33

Alpha-1 antitrypsin inhibits caspase-1 and protects from acute myocardial ischemia-reperfusion injury. J Mol Cell Cardiol (2011) 1.23

Heme oxygenase-1 is essential for and promotes tolerance to transplanted organs. FASEB J (2006) 1.14

Alpha-1-antitrypsin monotherapy reduces graft-versus-host disease after experimental allogeneic bone marrow transplantation. Proc Natl Acad Sci U S A (2011) 1.13

α-1 antitrypsin promotes semimature, IL-10-producing and readily migrating tolerogenic dendritic cells. J Immunol (2012) 1.04

Inhibition of IL-32 activation by α-1 antitrypsin suppresses alloreactivity and increases survival in an allogeneic murine marrow transplantation model. Blood (2011) 0.97

The circulating proteinase inhibitor α-1 antitrypsin regulates neutrophil degranulation and autoimmunity. Sci Transl Med (2014) 0.97

Pharmacologic inhibition of PKCα and PKCθ prevents GVHD while preserving GVL activity in mice. Blood (2013) 0.96

Concentration-dependent effects of native and polymerised alpha1-antitrypsin on primary human monocytes, in vitro. BMC Cell Biol (2004) 0.93

An association between Type 2 diabetes and alpha-antitrypsin deficiency. Diabet Med (2008) 0.92

Induction of transplantation tolerance-the potential of regulatory T cells. Transpl Immunol (2005) 0.92

Oxidative stress mediates a reduced expression of the activating receptor NKG2D in NK cells from end-stage renal disease patients. J Immunol (2009) 0.91

Tolerogenic dendritic cells and their potential applications. Immunology (2011) 0.88

Characterization of alpha1-antitrypsin as a heme oxygenase-1 suppressor in Alzheimer plasma. Neurobiol Dis (2006) 0.86

Reference and interpretive ranges for α(1)-antitrypsin quantitation by phenotype in adult and pediatric populations. Am J Clin Pathol (2012) 0.84

Differential graft-versus-leukaemia effect by CD28 and CD40 co-stimulatory blockade after graft-versus-host disease prophylaxis. Clin Exp Immunol (2002) 0.83

Immunoregulation effect by overexpression of heme oxygenase-1 on cardiac xenotransplantation. Transplant Proc (2011) 0.83

Microchimerism, donor dendritic cells, and alloimmune reactivity in recipients of Flt3 ligand-mobilized hemopoietic cells: modulation by tacrolimus. J Immunol (2000) 0.81

Are non-traditional CD4(+) CD69(+) CD25(-) regulatory T cells involved in disease progression of human hepatocellular carcinoma? J Gastroenterol Hepatol (2011) 0.80

Antioxidant status and alpha1-antiproteinase activity in subarachnoid hemorrhage patients. Life Sci (1998) 0.80

Human α1-Antitrypsin Binds to Heat-Shock Protein gp96 and Protects from Endogenous gp96-Mediated Injury In vivo. Front Immunol (2013) 0.80

Alpha-1--antitrypsin in aqueous humour from patients with corneal allograft rejection. Acta Ophthalmol Scand (2005) 0.79

Presence of alpha1-antitrypsin and transferrin in human follicular fluid--correlation with fertilization. Comp Biochem Physiol B Biochem Mol Biol (2002) 0.78