Published in Int J Mol Med on October 20, 2014
Genetic instabilities in human cancers. Nature (1998) 22.76
The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol (2007) 18.33
A DNA damage checkpoint response in telomere-initiated senescence. Nature (2003) 12.55
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature (2006) 11.76
Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat Genet (1998) 8.91
On the road to cancer: aneuploidy and the mitotic checkpoint. Nat Rev Cancer (2005) 7.53
A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J (1998) 7.39
Clinical implications of the p53 tumor-suppressor gene. N Engl J Med (1993) 7.29
p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis. Cancer Res (1990) 5.70
The spindle checkpoint: structural insights into dynamic signalling. Nat Rev Mol Cell Biol (2002) 4.53
Aurora-A - a guardian of poles. Nat Rev Cancer (2005) 4.11
Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death. Cancer Cell (2005) 3.69
Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint. Proc Natl Acad Sci U S A (2004) 3.69
The spindle checkpoint, aneuploidy, and cancer. Oncogene (2004) 3.61
Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53. Nat Genet (2003) 3.38
The Aurora kinase family in cell division and cancer. Biochim Biophys Acta (2008) 2.84
Mutations in the p53 gene: an early marker of neoplastic progression in ulcerative colitis. Gastroenterology (1994) 2.55
The causes and consequences of polyploidy in normal development and cancer. Annu Rev Cell Dev Biol (2011) 2.54
Regulation of p53 stability. Oncogene (1999) 2.54
DNA aneuploidy in colonic biopsies predicts future development of dysplasia in ulcerative colitis. Gastroenterology (1992) 2.48
Increased p53 mutation load in noncancerous colon tissue from ulcerative colitis: a cancer-prone chronic inflammatory disease. Cancer Res (2000) 2.31
APC/C Cdh1 targets aurora kinase to control reorganization of the mitotic spindle at anaphase. Curr Biol (2008) 2.18
Ulcerative colitis is a disease of accelerated colon aging: evidence from telomere attrition and DNA damage. Gastroenterology (2008) 2.14
Aurora A kinase (AURKA) in normal and pathological cell division. Cell Mol Life Sci (2012) 1.84
Early detection of malignancy in ulcerative colitis. A flow-cytometric DNA study. Cancer (1984) 1.80
Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions. EMBO J (2012) 1.71
Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53. Proc Natl Acad Sci U S A (1996) 1.68
Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice. Cancer Cell (2007) 1.59
Dysplasia complicating chronic ulcerative colitis: is immediate colectomy warranted? Dis Colon Rectum (2000) 1.59
Oxidative stress in ulcerative colitis-associated carcinogenesis. Pathol Res Pract (2008) 1.57
Telomere dysfunction, genome instability and cancer. Front Biosci (2008) 1.53
Pancolonic chromosomal instability precedes dysplasia and cancer in ulcerative colitis. Cancer Res (1999) 1.53
Aurora-A expression is independently associated with chromosomal instability in colorectal cancer. Neoplasia (2009) 1.39
DNA aneuploidy in ulcerative colitis. Gut (1986) 1.38
Genomic instability is an early event during the progression pathway of ulcerative-colitis-related neoplasia. Am J Pathol (1999) 1.35
The fate of low grade dysplasia in ulcerative colitis. Am J Gastroenterol (2002) 1.30
Chromosomal gains and losses in primary colorectal carcinomas detected by CGH and their associations with tumour DNA ploidy, genotypes and phenotypes. Br J Cancer (1999) 1.28
p53: guardian of ploidy. Mol Oncol (2011) 1.25
Ulcerative colitis-associated colorectal cancer arises in a field of short telomeres, senescence, and inflammation. Cancer Res (2011) 1.23
Telomere instability and cancer. Biochimie (2007) 1.16
p53 negatively regulates Aurora A via both transcriptional and posttranslational regulation. Cell Cycle (2012) 1.15
Aurora kinase A promotes inflammation and tumorigenesis in mice and human gastric neoplasia. Gastroenterology (2013) 1.07
Telomere shortening in human diseases. FEBS J (2013) 1.03
Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73. Cancer Cell (2012) 1.02
Diverse p53 alterations in ulcerative colitis-associated low-grade dysplasia: full-length gene sequencing in microdissected single crypts. J Pathol (2003) 1.01
Aurora A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice. Oncogene (2008) 1.00
p53 protein expression in ulcerative colitis-associated colorectal dysplasia and carcinoma. Hum Pathol (1994) 0.99
Spindle proteins Aurora A and BUB1B, but not Mad2, are aberrantly expressed in dysplastic mucosa of patients with longstanding ulcerative colitis. J Clin Pathol (2007) 0.96
Subcellular localization of the spindle proteins Aurora A, Mad2, and BUBR1 assessed by immunohistochemistry. J Histochem Cytochem (2007) 0.95
p53 immunohistochemistry of ulcerative colitis-associated with dysplasia and carcinoma. Pathol Int (1999) 0.92
Oxidative stress overrides the spindle checkpoint. Cell Cycle (2007) 0.92
High Frequency of Aneuploidy Defines Ulcerative Colitis-Associated Carcinomas: A Prognostic Comparison to Sporadic Colorectal Carcinomas. Ann Surg (2010) 0.91
Aurora kinase A (AURKA) expression in colorectal cancer liver metastasis is associated with poor prognosis. Br J Cancer (2013) 0.91
Immunohistochemical assessment of Ki67 and p53 expression assists the diagnosis and grading of ulcerative colitis-related dysplasia. Histopathology (2000) 0.89
Distribution of cell populations with DNA aneuploidy and p53 protein expression in ulcerative colitis. Eur J Gastroenterol Hepatol (1997) 0.88
Role of immunohistochemical markers in predicting progression of dysplasia to advanced neoplasia in patients with ulcerative colitis. Inflamm Bowel Dis (2011) 0.87
Immunohistochemical analysis of chromogranin A and p53 expressions in ulcerative colitis-associated neoplasia: neuroendocrine differentiation as an early event in the colitis-neoplasia sequence. Hum Pathol (2013) 0.84
Analysis of mutational spectra by denaturing capillary electrophoresis. Nat Protoc (2008) 0.84
Flow cytometric DNA ploidy pattern in dysplastic mucosa, and in primary and metastatic carcinomas in patients with longstanding ulcerative colitis. Br J Cancer (1991) 0.84
Reduced hTERT protein levels are associated with DNA aneuploidy in the colonic mucosa of patients suffering from longstanding ulcerative colitis. Int J Mol Med (2014) 0.84
Association of p53 accumulation with TP53 mutations, loss of heterozygosity at 17p13, and DNA ploidy status in 273 colorectal carcinomas. Diagn Mol Pathol (1998) 0.83
Separation principles of cycling temperature capillary electrophoresis. Electrophoresis (2012) 0.81
Telomere shortening correlates to dysplasia but not to DNA aneuploidy in longstanding ulcerative colitis. BMC Gastroenterol (2014) 0.80
Clonal expansions and short telomeres are associated with neoplasia in early-onset, but not late-onset, ulcerative colitis. Inflamm Bowel Dis (2013) 0.80
Aneuploidy is associated with TP53 expression but not with BRCA1 or TERT expression in sporadic colorectal cancer. Anticancer Res (2009) 0.79
Aneuploidy characterizes adjacent non-malignant mucosa of ulcerative colitis-associated but not sporadic colorectal carcinomas: a matched-pair analysis. Scand J Gastroenterol (2013) 0.78
Activation of p53 protein by telomeric (TTAGGG)n repeats. Nucleic Acids Res (2001) 0.78
Aneuploidy-associated gene expression signatures characterize malignant transformation in ulcerative colitis. Inflamm Bowel Dis (2013) 0.78
Mitotic Kinases and p53 Signaling. Biochem Res Int (2012) 0.78
Mutation analysis of TP53 exons 5-8 by automated constant denaturant capillary electrophoresis. Tumour Biol (2001) 0.76