Published in Front Genet on October 07, 2014
The primate-specific noncoding RNA HPAT5 regulates pluripotency during human preimplantation development and nuclear reprogramming. Nat Genet (2015) 0.98
The Reverse Transcriptase Encoded by LINE-1 Retrotransposons in the Genesis, Progression, and Therapy of Cancer. Front Chem (2016) 0.81
Activation of LINE-1 Retrotransposon Increases the Risk of Epithelial-Mesenchymal Transition and Metastasis in Epithelial Cancer. Curr Mol Med (2015) 0.77
Human LINE retrotransposons generate processed pseudogenes. Nat Genet (2000) 6.64
Lin28 promotes transformation and is associated with advanced human malignancies. Nat Genet (2009) 6.35
Hot L1s account for the bulk of retrotransposition in the human population. Proc Natl Acad Sci U S A (2003) 6.16
Natural mutagenesis of human genomes by endogenous retrotransposons. Cell (2010) 5.50
Human l1 retrotransposition is associated with genetic instability in vivo. Cell (2002) 4.79
Landscape of somatic retrotransposition in human cancers. Science (2012) 4.37
Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences. Nat Commun (2011) 4.07
The role of let-7 in cell differentiation and cancer. Endocr Relat Cancer (2010) 3.95
Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation. Proc Natl Acad Sci U S A (2009) 3.76
The maleless protein associates with the X chromosome to regulate dosage compensation in Drosophila. Cell (1991) 2.98
Viral-human chimeric transcript predisposes risk to liver cancer development and progression. Cancer Cell (2014) 2.53
Hypermethylation of let-7a-3 in epithelial ovarian cancer is associated with low insulin-like growth factor-II expression and favorable prognosis. Cancer Res (2007) 2.45
Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis. Nat Struct Mol Biol (2010) 2.30
Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma. Cell (2013) 2.28
Hypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer. PLoS Genet (2010) 2.27
Transposable elements are major contributors to the origin, diversification, and regulation of vertebrate long noncoding RNAs. PLoS Genet (2013) 2.07
Autoregulation of microRNA biogenesis by let-7 and Argonaute. Nature (2012) 1.85
LINE-1 ORF1 protein localizes in stress granules with other RNA-binding proteins, including components of RNA interference RNA-induced silencing complex. Mol Cell Biol (2007) 1.79
Human LINE-1 retrotransposon induces DNA damage and apoptosis in cancer cells. Cancer Cell Int (2006) 1.59
Distinct mechanisms for trans-mediated mobilization of cellular RNAs by the LINE-1 reverse transcriptase. Genome Res (2007) 1.50
Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks. PLoS Genet (2013) 1.48
Mapping the LINE1 ORF1 protein interactome reveals associated inhibitors of human retrotransposition. Nucleic Acids Res (2013) 1.31
Inhibition of endogenous reverse transcriptase antagonizes human tumor growth. Oncogene (2005) 1.30
Human endogenous retrovirus (HERV-K) reverse transcriptase as a breast cancer prognostic marker. Neoplasia (2008) 1.24
MOV10 RNA helicase is a potent inhibitor of retrotransposition in cells. PLoS Genet (2012) 1.17
Association of nuclear localization of a long interspersed nuclear element-1 protein in breast tumors with poor prognostic outcomes. Genes Cancer (2010) 1.12
Hsa-let-7a functions as a tumor suppressor in renal cell carcinoma cell lines by targeting c-myc. Biochem Biophys Res Commun (2011) 1.10
Isolation of cancer-specific chimeric transcripts induced by hypomethylation of the LINE-1 antisense promoter. Genomics (2009) 1.08
The Microprocessor controls the activity of mammalian retrotransposons. Nat Struct Mol Biol (2013) 1.07
Naturally occurring endo-siRNA silences LINE-1 retrotransposons in human cells through DNA methylation. Epigenetics (2012) 1.04
Comprehensive analysis of microRNA genomic loci identifies pervasive repetitive-element origins. Mob Genet Elements (2011) 1.02
Prognostic value of LINE-1 retrotransposon expression and its subcellular localization in breast cancer. Breast Cancer Res Treat (2012) 0.98
Burgeoning evidence indicates that microRNAs were initially formed from transposable element sequences. Mob Genet Elements (2014) 0.94
A new lncRNA, APTR, associates with and represses the CDKN1A/p21 promoter by recruiting polycomb proteins. PLoS One (2014) 0.94
Mutation in a primate-conserved retrotransposon reveals a noncoding RNA as a mediator of infantile encephalopathy. Proc Natl Acad Sci U S A (2012) 0.91
Characterization of L1 ORF1p self-interaction and cellular localization using a mammalian two-hybrid system. PLoS One (2013) 0.89
Structural insights into RISC assembly facilitated by dsRNA-binding domains of human RNA helicase A (DHX9). Nucleic Acids Res (2013) 0.86
Functional microRNAs and target sites are created by lineage-specific transposition. Hum Mol Genet (2013) 0.86
Distinctive patterns of epigenetic marks are associated with promoter regions of mouse LINE-1 and LTR retrotransposons. Mob DNA (2013) 0.84
Feedback inhibition of L1 and alu retrotransposition through altered double strand break repair kinetics. Mob DNA (2010) 0.84
OrbId: Origin-based identification of microRNA targets. Mob Genet Elements (2012) 0.83
Protein interactions with piALU RNA indicates putative participation of retroRNA in the cell cycle, DNA repair and chromatin assembly. Mob Genet Elements (2012) 0.81
Does Lin28 Antagonize miRNA-Mediated Repression by Displacing miRISC from Target mRNAs? Front Genet (2012) 0.81
Silencing of LINE-1 retrotransposons contributes to variation in small noncoding RNA expression in human cancer cells. Oncotarget (2014) 0.81