Quantity of dietary protein intake, but not pattern of intake, affects net protein balance primarily through differences in protein synthesis in older adults.

PubWeight™: 0.94‹?›

🔗 View Article (PMID 25352437)

Published in Am J Physiol Endocrinol Metab on October 28, 2014

Authors

Il-Young Kim1, Scott Schutzler2, Amy Schrader3, Horace Spencer3, Patrick Kortebein2, Nicolaas E P Deutz2, Robert R Wolfe2, Arny A Ferrando2

Author Affiliations

1: Department of Geriatrics, the Center for Translational Research in Aging & Longevity, Donald W. Reynolds Institute on Aging, Little Rock, Arkansas; and iykim@uams.edu.
2: Department of Geriatrics, the Center for Translational Research in Aging & Longevity, Donald W. Reynolds Institute on Aging, Little Rock, Arkansas; and.
3: College of Medicine Biostatistics, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

Articles citing this

Hypoenergetic diet-induced reductions in myofibrillar protein synthesis are restored with resistance training and balanced daily protein ingestion in older men. Am J Physiol Endocrinol Metab (2015) 0.98

Protein Considerations for Optimising Skeletal Muscle Mass in Healthy Young and Older Adults. Nutrients (2016) 0.80

The anabolic response to a meal containing different amounts of protein is not limited by the maximal stimulation of protein synthesis in healthy young adults. Am J Physiol Endocrinol Metab (2015) 0.79

Applications of stable, nonradioactive isotope tracers in in vivo human metabolic research. Exp Mol Med (2016) 0.77

The Link between Dietary Protein Intake, Skeletal Muscle Function and Health in Older Adults. Healthcare (Basel) (2015) 0.75

Optimizing Protein Intake in Adults: Interpretation and Application of the Recommended Dietary Allowance Compared with the Acceptable Macronutrient Distribution Range. Adv Nutr (2017) 0.75

Live strong and prosper: the importance of skeletal muscle strength for healthy ageing. Biogerontology (2016) 0.75

Is Meeting the Recommended Dietary Allowance (RDA) for Protein Related to Body Composition among Older Adults?: Results from the Cardiovascular Health of Seniors and Built Environment Study. J Nutr Health Aging (2016) 0.75

Preserving Healthy Muscle during Weight Loss. Adv Nutr (2017) 0.75

Protein Consumption and the Elderly: What Is the Optimal Level of Intake? Nutrients (2016) 0.75

Dietary Protein in Older Adults: Adequate Daily Intake but Potential for Improved Distribution. Nutrients (2017) 0.75

Effectiveness of essential amino acid supplementation in stimulating whole body net protein anabolism is comparable between COPD patients and healthy older adults. Metabolism (2016) 0.75

Growing older with health and vitality: a nexus of physical activity, exercise and nutrition. Biogerontology (2016) 0.75

Short term elevation in dietary protein intake does not worsen insulin resistance or lipids in older adults with metabolic syndrome: a randomized-controlled trial. BMC Nutr (2017) 0.75

Articles cited by this

Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol (1998) 10.23

Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults. Am J Clin Nutr (2003) 2.65

Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased eIF4F formation. J Nutr (2000) 2.46

Amino acid ingestion improves muscle protein synthesis in the young and elderly. Am J Physiol Endocrinol Metab (2003) 2.41

Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men. Am J Clin Nutr (2008) 2.39

Human muscle protein synthesis is modulated by extracellular, not intramuscular amino acid availability: a dose-response study. J Physiol (2003) 2.39

Transmembrane transport and intracellular kinetics of amino acids in human skeletal muscle. Am J Physiol (1995) 2.29

Exogenous amino acids stimulate net muscle protein synthesis in the elderly. J Clin Invest (1998) 2.25

Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first-pass splanchnic extraction. Am J Physiol (1999) 2.21

Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids. Am J Clin Nutr (2005) 2.15

Physiologic hyperinsulinemia stimulates protein synthesis and enhances transport of selected amino acids in human skeletal muscle. J Clin Invest (1995) 2.12

Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6. J Biol Chem (1999) 2.09

Resistance exercise enhances myofibrillar protein synthesis with graded intakes of whey protein in older men. Br J Nutr (2012) 1.87

Protein ingestion to stimulate myofibrillar protein synthesis requires greater relative protein intakes in healthy older versus younger men. J Gerontol A Biol Sci Med Sci (2014) 1.84

Dietary protein distribution positively influences 24-h muscle protein synthesis in healthy adults. J Nutr (2014) 1.76

A moderate serving of high-quality protein maximally stimulates skeletal muscle protein synthesis in young and elderly subjects. J Am Diet Assoc (2009) 1.70

Aging does not impair the anabolic response to a protein-rich meal. Am J Clin Nutr (2007) 1.58

Regulation of muscle protein by amino acids. J Nutr (2002) 1.53

Acute response of net muscle protein balance reflects 24-h balance after exercise and amino acid ingestion. Am J Physiol Endocrinol Metab (2002) 1.48

Differences in muscle protein synthesis and anabolic signaling in the postabsorptive state and in response to food in 65-80 year old men and women. PLoS One (2008) 1.31

Precursor pools of protein synthesis: a stable isotope study in a swine model. Am J Physiol (1994) 1.29

Nonessential amino acids are not necessary to stimulate net muscle protein synthesis in healthy volunteers. J Nutr Biochem (1999) 1.19

Molecular mechanisms involved in muscle wasting in cancer and ageing: cachexia versus sarcopenia. Int J Biochem Cell Biol (2004) 1.12

Exogenous amino acids stimulate human muscle anabolism without interfering with the response to mixed meal ingestion. Am J Physiol Endocrinol Metab (2004) 1.09

Is there a maximal anabolic response to protein intake with a meal? Clin Nutr (2012) 1.08

Anabolic resistance of muscle protein synthesis with aging. Exerc Sport Sci Rev (2013) 1.04

Increased intestinal amino-acid retention from the addition of carbohydrates to a meal. Clin Nutr (1995) 1.01

Dose-dependent responses of myofibrillar protein synthesis with beef ingestion are enhanced with resistance exercise in middle-aged men. Appl Physiol Nutr Metab (2012) 0.96

Dietary essential amino acids are highly anabolic in pediatric patients with cystic fibrosis. J Cyst Fibros (2013) 0.93

Hydrolyzed casein and whey protein meals comparably stimulate net whole-body protein synthesis in COPD patients with nutritional depletion without an additional effect of leucine co-ingestion. Clin Nutr (2013) 0.93

Sexually dimorphic effect of aging on skeletal muscle protein synthesis. Biol Sex Differ (2012) 0.87

Whole-body protein turnover in elderly men and women: responses to two protein intakes. Am J Clin Nutr (1995) 0.81

Effect of variable protein intake on whole-body protein turnover in young men and women. Am J Clin Nutr (1995) 0.81

Animal models for determining amino acid digestibility in humans - a review. Br J Nutr (2012) 0.80

Prior protein intake may affect phenylalanine kinetics measured in healthy adult volunteers consuming 1 g protein. kg-1. d-1. J Nutr (1999) 0.79

An approach to defining the upper safe limits of amino acid intake. J Nutr (2008) 0.78