Published in J Gen Physiol on January 01, 1989
Divalent cation selectivity for external block of voltage-dependent Na+ channels prolonged by batrachotoxin. Zn2+ induces discrete substates in cardiac Na+ channels. J Gen Physiol (1991) 1.66
Calcium ion as a cofactor in Na channel gating. Proc Natl Acad Sci U S A (1991) 1.60
On the structural basis for size-selective permeation of organic cations through the voltage-gated sodium channel. Effect of alanine mutations at the DEKA locus on selectivity, inhibition by Ca2+ and H+, and molecular sieving. J Gen Physiol (1997) 1.59
Gating kinetics of batrachotoxin-modified Na+ channels in the squid giant axon. Voltage and temperature effects. Biophys J (1992) 1.44
Competitive binding interaction between Zn2+ and saxitoxin in cardiac Na+ channels. Evidence for a sulfhydryl group in the Zn2+/saxitoxin binding site. Biophys J (1991) 1.33
Ion permeation in normal and batrachotoxin-modified Na+ channels in the squid giant axon. J Gen Physiol (1991) 1.31
Zn2(+)-induced subconductance events in cardiac Na+ channels prolonged by batrachotoxin. Current-voltage behavior and single-channel kinetics. J Gen Physiol (1991) 1.31
Modeling ion permeation through batrachotoxin-modified Na+ channels from rat skeletal muscle with a multi-ion pore. Biophys J (1992) 1.22
External pH effects on the depolarization-activated K channels in guard cell protoplasts of Vicia faba. J Gen Physiol (1994) 1.15
Ion conduction in substates of the batrachotoxin-modified Na+ channel from toad skeletal muscle. Biophys J (1993) 1.11
Identification of new batrachotoxin-sensing residues in segment IIIS6 of the sodium channel. J Biol Chem (2011) 1.00
Permeation of Na+ through open and Zn(2+)-occupied conductance states of cardiac sodium channels modified by batrachotoxin: exploring ion-ion interactions in a multi-ion channel. Biophys J (1994) 1.00
Calcium block of single sodium channels: role of a pore-lining aromatic residue. Biophys J (2007) 0.95
Lipid surface charge does not influence conductance or calcium block of single sodium channels in planar bilayers. Biophys J (1992) 0.93
Voltage dependence and stability of the gating kinetics of the fast chloride channel from rat skeletal muscle. J Physiol (1990) 0.92
Ion channels in transit: voltage-gated Na and K channels in axoplasmic organelles of the squid Loligo pealei. Proc Natl Acad Sci U S A (1991) 0.90
A simple model for surface charge on ion channel proteins. Biophys J (1994) 0.86
Alkaloid-modified sodium channels from lobster walking leg nerves in planar lipid bilayers. J Gen Physiol (1992) 0.84
Purified, modified eel sodium channels are active in planar bilayers in the absence of activating neurotoxins. Proc Natl Acad Sci U S A (1989) 0.83
Profiles of permeation through Na-channels. Biophys J (1993) 0.81
A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol (1952) 160.83
The effect of sodium ions on the electrical activity of giant axon of the squid. J Physiol (1949) 149.79
The action of calcium on the electrical properties of squid axons. J Physiol (1957) 35.98
Voltage clamp experiments on internally perfused giant axons. J Physiol (1965) 14.69
Data transformations for improved display and fitting of single-channel dwell time histograms. Biophys J (1987) 9.64
Sodium channels and gating currents. Physiol Rev (1981) 5.73
Gating kinetics of Ca2+-activated K+ channels from rat muscle incorporated into planar lipid bilayers. Evidence for two voltage-dependent Ca2+ binding reactions. J Gen Physiol (1983) 5.30
Ion transport through pores: a rate-theory analysis. Biochim Biophys Acta (1973) 4.94
Potassium and sodium ion current noise in the membrane of the squid giant axon. J Physiol (1975) 4.03
Statistical analysis of single sodium channels. Effects of N-bromoacetamide. Biophys J (1984) 3.01
Ammonium ion currents in the squid giant axon. J Gen Physiol (1969) 2.98
A high capacity data recording device based on a digital audio processor and a video cassette recorder. Biophys J (1985) 2.84
Batrachotoxin-modified sodium channels in planar lipid bilayers. Ion permeation and block. J Gen Physiol (1987) 2.55
Single sodium channels from rat brain incorporated into planar lipid bilayer membranes. Nature (1983) 2.28
Batrachotoxin-activated Na+ channels in planar lipid bilayers. Competition of tetrodotoxin block by Na+. J Gen Physiol (1984) 2.26
Sodium channel selectivity. Dependence on internal permeant ion concentration. J Gen Physiol (1976) 2.26
Sodium channel permeation in squid axons. II: Non-independence and current-voltage relations. J Physiol (1980) 2.10
Voltage-dependent blockade of muscle Na+ channels by guanidinium toxins. J Gen Physiol (1984) 1.84
Further analysis of the mechanisms of action of batrachotoxin on the membrane of myelinated nerve. Neuroscience (1979) 1.63
Voltage-dependent block by saxitoxin of sodium channels incorporated into planar lipid bilayers. Biophys J (1984) 1.60
Gating of sodium and potassium channels. J Membr Biol (1985) 1.59
Gating kinetics of batrachotoxin-modified sodium channels in neuroblastoma cells determined from single-channel measurements. Biophys J (1984) 1.58
Batrachotoxin-modified sodium channels in planar lipid bilayers. Characterization of saxitoxin- and tetrodotoxin-induced channel closures. J Gen Physiol (1987) 1.57
Trimethyloxonium modification of single batrachotoxin-activated sodium channels in planar bilayers. Changes in unit conductance and in block by saxitoxin and calcium. J Gen Physiol (1986) 1.52
Functional reconstitution of the purified brain sodium channel in planar lipid bilayers. Proc Natl Acad Sci U S A (1985) 1.49
The effect of tetramethylammonium on single sodium channel currents. Biophys J (1981) 1.48
Single Na+ channels activated by veratridine and batrachotoxin. J Gen Physiol (1987) 1.41
Non-random openings and concentration-dependent lifetimes of glutamate-gated channels in muscle membrane. Nature (1981) 1.39
Batrachotoxin as a tool to study voltage-sensitive sodium channels of excitable membranes. Prog Biophys Mol Biol (1985) 1.35
Single-channel properties of the reconstituted voltage-regulated Na channel isolated from the electroplax of Electrophorus electricus. Proc Natl Acad Sci U S A (1984) 1.27
Comparison of ionic selectivity of batrachotoxin-activated channels with different tetrodotoxin dissociation constants. J Gen Physiol (1979) 1.26
Purified and unpurified sodium channels from eel electroplax in planar lipid bilayers. J Gen Physiol (1987) 1.23
Single sodium channels from the squid giant axon. Biophys J (1987) 1.18
Sodium channels in planar lipid bilayers. Channel gating kinetics of purified sodium channels modified by batrachotoxin. J Gen Physiol (1986) 1.13
Interactions of permeant cations with sodium channels of squid axon membranes. Biophys J (1985) 1.08
Analysis of sodium current fluctuations in the cut-open squid giant axon. J Gen Physiol (1984) 0.89
Partial purification and characterization of the (Ca2+ + Mg2+)-ATPase from squid optic nerve plasma membrane. Biochim Biophys Acta (1984) 0.85
Inactivation of the sodium channel. II. Gating current experiments. J Gen Physiol (1977) 14.17
Charge movement associated with the opening and closing of the activation gates of the Na channels. J Gen Physiol (1974) 13.07
Inactivation of the sodium channel. I. Sodium current experiments. J Gen Physiol (1977) 12.35
Negative conductance caused by entry of sodium and cesium ions into the potassium channels of squid axons. J Gen Physiol (1972) 10.92
Currents related to movement of the gating particles of the sodium channels. Nature (1973) 9.80
Destruction of sodium conductance inactivation in squid axons perfused with pronase. J Gen Physiol (1973) 8.53
Voltage-sensing residues in the S2 and S4 segments of the Shaker K+ channel. Neuron (1996) 8.20
Conduction and selectivity in potassium channels. J Membr Biol (1983) 6.41
Gating kinetics of Ca2+-activated K+ channels from rat muscle incorporated into planar lipid bilayers. Evidence for two voltage-dependent Ca2+ binding reactions. J Gen Physiol (1983) 5.30
Charybdotoxin, a protein inhibitor of single Ca2+-activated K+ channels from mammalian skeletal muscle. Nature (1985) 4.95
Varieties of calcium-activated potassium channels. Annu Rev Physiol (1989) 4.66
Atomic scale movement of the voltage-sensing region in a potassium channel measured via spectroscopy. Nature (1999) 4.56
Gating currents from a nonconducting mutant reveal open-closed conformations in Shaker K+ channels. Neuron (1993) 4.55
Gating currents of the sodium channels: three ways to block them. Science (1974) 4.13
Characterizing voltage-dependent conformational changes in the Shaker K+ channel with fluorescence. Neuron (1997) 4.08
Distribution and kinetics of membrane dielectric polarization. 1. Long-term inactivation of gating currents. J Gen Physiol (1982) 3.85
Reconstitution in planar lipid bilayers of a Ca2+-dependent K+ channel from transverse tubule membranes isolated from rabbit skeletal muscle. Proc Natl Acad Sci U S A (1982) 3.85
Calcium-activated potassium channels. Curr Opin Neurobiol (1998) 3.81
Voltage sensors in domains III and IV, but not I and II, are immobilized by Na+ channel fast inactivation. Neuron (1999) 3.74
Kinetics of Ca2+-activated K+ channels from rabbit muscle incorporated into planar bilayers. Evidence for a Ca2+ and Ba2+ blockade. J Gen Physiol (1983) 3.72
Voltage-dependent capacitance in lipid bilayers made from monolayers. Biophys J (1978) 3.54
Correlation between charge movement and ionic current during slow inactivation in Shaker K+ channels. J Gen Physiol (1997) 3.54
Voltage-dependent channels in planar lipid bilayer membranes. Physiol Rev (1981) 3.51
Voltage-dependent proton transport by the voltage sensor of the Shaker K+ channel. Neuron (1997) 3.29
Gating of Shaker K+ channels: I. Ionic and gating currents. Biophys J (1994) 3.28
Multi-ion conduction and selectivity in the high-conductance Ca++-activated K+ channel from skeletal muscle. Biophys J (1986) 3.24
Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit. Science (1999) 3.05
A sodium channel gating model based on single channel, macroscopic ionic, and gating currents in the squid giant axon. Biophys J (1991) 2.98
Sodium and potassium conductance changes during a membrane action potential. J Physiol (1970) 2.94
A high capacity data recording device based on a digital audio processor and a video cassette recorder. Biophys J (1985) 2.84
Histidine scanning mutagenesis of basic residues of the S4 segment of the shaker k+ channel. J Gen Physiol (2001) 2.79
Cut-open oocyte voltage-clamp technique. Methods Enzymol (1998) 2.67
Structural implications of fluorescence quenching in the Shaker K+ channel. J Gen Physiol (1998) 2.65
Phospholipid bilayers made from monolayers on patch-clamp pipettes. Biophys J (1983) 2.54
A method for determining the unitary functional capacity of cloned channels and transporters expressed in Xenopus laevis oocytes. J Membr Biol (1995) 2.46
Sodium influxes in internally perfused squid giant axon during voltage clamp. J Physiol (1969) 2.43
Coupling of voltage-dependent gating and Ba++ block in the high-conductance, Ca++-activated K+ channel. J Gen Physiol (1987) 2.41
Sodium channel activation in the squid giant axon. Steady state properties. J Gen Physiol (1985) 2.35
Gating currents in Shaker K+ channels. Implications for activation and inactivation models. Biophys J (1992) 2.27
Total charge movement per channel. The relation between gating charge displacement and the voltage sensitivity of activation. J Gen Physiol (1997) 2.26
Role of surface electrostatics in the operation of a high-conductance Ca2+-activated K+ channel. Biochemistry (1989) 2.25
Kinetic properties and inactivation of the gating currents of sodium channels in squid axon. Philos Trans R Soc Lond B Biol Sci (1975) 2.25
Characterization of and modulation by a beta-subunit of a human maxi KCa channel cloned from myometrium. Receptors Channels (1995) 2.24
Effect of phospholipid surface charge on the conductance and gating of a Ca2+-activated K+ channel in planar lipid bilayers. J Membr Biol (1985) 2.23
Analysis of the effects of calcium or magnesium on voltage-clamp currents in perfused squid axons bathed in solutions of high potassium. J Gen Physiol (1969) 2.19
Kinetics of the opening and closing of individual excitability-inducing material channels in a lipid bilayer. J Gen Physiol (1974) 2.15
Voltage-controlled gating in a large conductance Ca2+-sensitive K+channel (hslo). Proc Natl Acad Sci U S A (1997) 2.11
Distribution and kinetics of membrane dielectric polarization. II. Frequency domain studies of gating currents. J Gen Physiol (1982) 2.09
Role of the S4 segment in a voltage-dependent calcium-sensitive potassium (hSlo) channel. J Biol Chem (1998) 2.03
Solute inaccessible aqueous volume changes during opening of the potassium channel of the squid giant axon. Biophys J (1990) 2.02
Anatomy of the equine temporomandibular joint: study by gross dissection, vascular injection and section. Equine Vet J (2006) 2.00
S4 mutations alter gating currents of Shaker K channels. Biophys J (1994) 1.97
Activation of squid axon K+ channels. Ionic and gating current studies. J Gen Physiol (1985) 1.92
Conduction, Blockade and Gating in a Ca -activated K Channel Incorporated into Planar Lipid Bilayers. Biophys J (1984) 1.89
Mode of action of iberiotoxin, a potent blocker of the large conductance Ca(2+)-activated K+ channel. Biophys J (1992) 1.86
Sodium dependence of the inward spread of activation in isolated twitch muscle fibres of the frog. J Physiol (1972) 1.86
Nile blue fluorescence signals from cut single muscle fibers under voltage or current clamp conditions. J Gen Physiol (1978) 1.84
Temperature effects on gating currents in the squid giant axon. Biophys J (1978) 1.78
Effect of the anesthetics benzyl alcohol and chloroform on bilayers made from monolayers. Biophys J (1979) 1.78
Induced capacitance in the squid giant axon. Lipophilic ion displacement currents. J Gen Physiol (1983) 1.75
Mechanisms of Cs+ blockade in a Ca2+-activated K+ channel from smooth muscle. Biophys J (1987) 1.74
RNA editing generates a diverse array of transcripts encoding squid Kv2 K+ channels with altered functional properties. Neuron (1997) 1.71
Interaction of internal Ba2+ with a cloned Ca(2+)-dependent K+ (hslo) channel from smooth muscle. J Gen Physiol (1996) 1.70
Gating current noise produced by elementary transitions in Shaker potassium channels. Science (1994) 1.68
Influence of cholesterol on water penetration into bilayers. Science (1982) 1.68
Sodium channel gating currents. Origin of the rising phase. J Gen Physiol (1987) 1.68
Sodium and gating current time shifts resulting from changes in initial conditions. J Gen Physiol (1983) 1.68
Activation by divalent cations of a Ca2+-activated K+ channel from skeletal muscle membrane. J Gen Physiol (1988) 1.67
Three distinct and sequential steps in the release of sodium ions by the Na+/K+-ATPase. Nature (2000) 1.67
Voltage gating of Shaker K+ channels. The effect of temperature on ionic and gating currents. J Gen Physiol (1998) 1.66
Streaming potential measurements in Ca2+-activated K+ channels from skeletal and smooth muscle. Coupling of ion and water fluxes. Biophys J (1989) 1.65
Saxitoxin and ouabain binding activity of isolated skeletal muscle membrane as indicators of surface origin and purity. Biochim Biophys Acta (1983) 1.61
Phloretin-induced changes in ion transport across lipid bilayer membranes. J Gen Physiol (1977) 1.61
Gating of sodium and potassium channels. J Membr Biol (1985) 1.59
Localization of the K+ lock-In and the Ba2+ binding sites in a voltage-gated calcium-modulated channel. Implications for survival of K+ permeability. J Gen Physiol (1999) 1.58
Mechanism for channel gating in excitable bilayers. Ann N Y Acad Sci (1975) 1.51
Phosphorylation affects voltage gating of the delayed rectifier K+ channel by electrostatic interactions. Neuron (1990) 1.51
Properties of the sodium channel gating current. Cold Spring Harb Symp Quant Biol (1976) 1.50
The rate of action of tetrodotoxin on sodium conductance in the squid giant axon. Philos Trans R Soc Lond B Biol Sci (1975) 1.47
Single-channel, macroscopic, and gating currents from sodium channels in the squid giant axon. Biophys J (1991) 1.45
Gating kinetics of batrachotoxin-modified Na+ channels in the squid giant axon. Voltage and temperature effects. Biophys J (1992) 1.44
Probing a Ca2+-activated K+ channel with quaternary ammonium ions. Pflugers Arch (1988) 1.44
Nonactin-K+ complex as a probe for membrane asymmetry. Biophys J (1976) 1.44
Periodic perturbations in Shaker K+ channel gating kinetics by deletions in the S3-S4 linker. Proc Natl Acad Sci U S A (2001) 1.44
[Latin-American consensus document on irritable bowel syndrome]. Gastroenterol Hepatol (2004) 1.42
Detection of K+ and Cl-channels from calf cardiac sarcolemma in planar lipid bilayer membranes. Nature (1982) 1.42
Gating currents associated with potassium channel activation. Nature (1982) 1.42
Some anthropological aspects of the prehistoric Tyrolean ice man. Science (1992) 1.41
Charge-shift probes of membrane potential. Characterization of aminostyrylpyridinium dyes on the squid giant axon. Biophys J (1985) 1.41
Extracellular Mg(2+) modulates slow gating transitions and the opening of Drosophila ether-à-Go-Go potassium channels. J Gen Physiol (2000) 1.39
Kramers' diffusion theory applied to gating kinetics of voltage-dependent ion channels. Biophys J (1999) 1.39
Potassium conductance of the squid giant axon. Single-channel studies. J Gen Physiol (1988) 1.38
Characterization of oral double balloon endoscopy in the dog. Vet J (2012) 1.38
Fluorescence intensity changes associated with contractile activation in frog muscle stained with Nile Blue A. J Physiol (1975) 1.38
Comments on the measurement of gating currents in the frequency domain. Biophys J (1979) 1.37
Modulation of the Shaker K(+) channel gating kinetics by the S3-S4 linker. J Gen Physiol (2000) 1.37