Published in Chin J Cancer Res on October 01, 2014
Superoxide radical and superoxide dismutases. Annu Rev Biochem (1995) 8.49
The phenomenon of the acute phase response. Ann N Y Acad Sci (1982) 6.14
Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group. Ann Intern Med (2004) 5.63
Myofibroblasts. I. Paracrine cells important in health and disease. Am J Physiol (1999) 4.99
Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor. EMBO J (1988) 4.54
Free radicals in biology: oxidative stress and the effects of ionizing radiation. Int J Radiat Biol (1994) 4.04
Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor. J Biol Chem (1990) 3.25
Cytokine therapeutics: lessons from interferon alpha. Proc Natl Acad Sci U S A (1994) 2.90
Interactions between cytokines and alpha 2-macroglobulin. Immunol Today (1990) 2.49
Trends in the development of radioprotective agents. Drug Discov Today (2007) 2.01
The radiation-induced fibroatrophic process: therapeutic perspective via the antioxidant pathway. Radiother Oncol (2004) 1.92
Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues. Cell Tissue Res (1992) 1.90
Alpha 2-macroglobulin, a multifunctional binding protein with targeting characteristics. FASEB J (1992) 1.86
Alpha-macroglobulins: structure, shape, and mechanism of proteinase complex formation. J Biol Chem (1989) 1.84
Subcutaneous administration of amifostine during fractionated radiotherapy: a randomized phase II study. J Clin Oncol (2000) 1.78
Serious adverse effects of amifostine during radiotherapy in head and neck cancer patients. Radiother Oncol (2004) 1.74
Radioprotectors in radiotherapy. J Radiat Res (2001) 1.74
Recent progress in defining mechanisms and potential targets for prevention of normal tissue injury after radiation therapy. Int J Radiat Oncol Biol Phys (2005) 1.73
Matrix metalloproteinases and their inhibitors in tumour growth and invasion. Ann Med (1999) 1.71
Radioprotectors and mitigators of radiation-induced normal tissue injury. Oncologist (2010) 1.71
A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury. Free Radic Biol Med (2002) 1.65
LDL receptor-related protein: a multiligand receptor for lipoprotein and proteinase catabolism. FASEB J (1995) 1.64
Role of interleukin 6 (IL-6) in protection from lethal irradiation and in endocrine responses to IL-1 and tumor necrosis factor. J Exp Med (1992) 1.38
Identification of alpha 2-macroglobulin as a carrier protein for IL-6. J Immunol (1989) 1.36
Detection of interleukin-6 and alpha 2-macroglobulin immunoreactivity in cortex and hippocampus of Alzheimer's disease patients. Lab Invest (1992) 1.28
Temporal modulation of TGF-beta 1 and beta-actin gene expression in pig skin and muscular fibrosis after ionizing radiation. Radiat Res (1993) 1.26
The gut: a cytokine-generating organ in systemic inflammation? Shock (1995) 1.25
Intratracheal injection of manganese superoxide dismutase (MnSOD) plasmid/liposomes protects normal lung but not orthotopic tumors from irradiation. Gene Ther (2000) 1.23
Role of cytokines (interleukin 1, tumor necrosis factor, and transforming growth factor beta) in natural and lipopolysaccharide-enhanced radioresistance. J Exp Med (1991) 1.23
Osteoradionecrosis of the jaws: current understanding of its pathophysiology and treatment. Br J Oral Maxillofac Surg (2008) 1.14
Cytokine binding and clearance properties of proteinase-activated alpha 2-macroglobulins. Lab Invest (1991) 1.14
Bacq and Alexander Award lecture--chemical radioprotection: past, present, and future prospects. Int J Radiat Biol (1998) 1.01
Delayed radioprotection by nuclear transcription factor kappaB -mediated induction of manganese superoxide dismutase in human microvascular endothelial cells after exposure to the free radical scavenger WR1065. Free Radic Biol Med (2005) 1.00
Serum alpha globulin fraction: survival-and-recovery effect in irradiated mice. Science (1967) 0.99
alpha 1-Proteinase inhibitor, alpha 1-antichymotrypsin, and alpha 2-macroglobulin are the antiapoptotic factors of vascular smooth muscle cells. J Biol Chem (2000) 0.99
Preclinical modeling of improved amifostine (Ethyol) use in radiation therapy. Semin Radiat Oncol (2002) 0.95
Oxidized alpha2-macroglobulin (alpha2M) differentially regulates receptor binding by cytokines/growth factors: implications for tissue injury and repair mechanisms in inflammation. J Immunol (1998) 0.94
Alpha 2-macroglobulin and the alpha 2-macroglobulin receptor/LRP. A growth regulatory axis. Ann N Y Acad Sci (1994) 0.93
Modulation of fibroblastic cytoskeletal features during wound healing and fibrosis. Pathol Res Pract (1994) 0.93
Regeneration of bone marrow cells and thymus induced by 19S alpha-2 globulin in irradiated mice. Nature (1968) 0.90
Intraluminal pancreatic serine protease activity, mucosal permeability, and shock: a review. Shock (2006) 0.89
The structural basis of increased vascular permeabiligy after graded thermal injury--light and electron microscopic studies. Ann N Y Acad Sci (1968) 0.89
The radioprotective effect of alpha2-macroglobulin: a morphological study of rat liver. Med Sci Monit (2009) 0.87
Abnormal phenotype of cultured fibroblasts in human skin with chronic radiotherapy damage. Radiother Oncol (1998) 0.87
Role of protein oxidation in aging and in age-associated neurodegenerative diseases. Life Sci (1994) 0.86
Tamoxifen enhancement of TNF-alpha induced MnSOD expression: modulation of NF-kappaB dimerization. Oncogene (2002) 0.85
STAT3/NFkappaB interplay in the regulation of alpha2-macroglobulin gene expression during rat liver development and the acute phase response. IUBMB Life (2007) 0.83
Reduction of inflammation by decreasing production of interleukin-1 or by specific receptor antagonism. Int J Tissue React (1992) 0.83
The effects of alpha M-foetoprotein, an acute phase protein, and BaSO4-induced injury on IgE-mediated, systemic anaphylaxis in the rat. Br J Exp Pathol (1986) 0.82
Transforming growth factor-beta stimulates the expression of alpha 2-macroglobulin by cultured bovine adrenocortical cells. J Biol Chem (1990) 0.81
Radiation protection by diethyldithiocarbamate: protection of membrane and DNA in vitro and in vivo against gamma-radiation. J Radiat Res (2004) 0.81
Structure of the human alpha-2 macroglobulin gene and its promotor. Biochem Biophys Res Commun (1992) 0.81
Alpha 2 macroglobulin of the rat, an acute phase protein, mitigates the early course of endotoxin shock. Br J Exp Pathol (1986) 0.81
Identification of transformed alpha 2-macroglobulin as a growth hormone-binding protein in human blood. J Clin Endocrinol Metab (1995) 0.79
Alpha 2-macroglobulin. A multifunctional binding and targeting protein with possible roles in immunity and autoimmunity. Ann N Y Acad Sci (1994) 0.79
The radioprotective activities of turpentine-induced inflammation and alpha2-macroglobulin: the effect of dexamethasone on the radioprotective efficacy of the inflammation. J Radiat Res (2003) 0.79
Maternal serum alpha 2-macroglobulin and fetal growth retardation. Obstet Gynecol (1991) 0.78
Early results of the screening program for radioprotectors. Int J Radiat Oncol Biol Phys (1982) 0.78
The acute-phase protein alpha2-macroglobulin plays an important role in radioprotection in the rat. Shock (2009) 0.77
[The pathogenesis of osteoradionecrosis]. Rev Stomatol Chir Maxillofac (1993) 0.77
Effect of radioprotectant WR 2721 on cyclic nucleotides, prostaglandins, and lysosomes. Radiat Res (1983) 0.77
The myofibroblast markers α-SM actin and β-actin are differentially expressed in 2 and 3-D culture models of fibrotic and normal skin. Cytotechnology (1998) 0.76
Regulation of alpha 2-macroglobulin gene expression by interleukin-6. Ann N Y Acad Sci (1994) 0.76
Irradiation increases proteolysis in erythrocyte ghosts: a spin label study. Radiat Environ Biophys (1992) 0.76
Nuclear localization and binding affinity of STAT5b for the alpha(2)-macroglobulin gene promoter during rat liver development and the acute-phase response. Acta Biochim Pol (2007) 0.76
Administration of rat acute-phase protein α(2)-macroglobulin before total-body irradiation initiates cytoprotective mechanisms in the liver. Radiat Environ Biophys (2010) 0.76
Pretreatment with alpha 2-macroglobulin leads to recovery of rats exposed to a lethal scald. Burns (1994) 0.75