Telomere attrition and candidate gene mutations preceding monosomy 7 in aplastic anemia.

PubWeight™: 0.91‹?›

🔗 View Article (PMID 25406353)

Published in Blood on November 18, 2014

Authors

Bogdan Dumitriu1, Xingmin Feng1, Danielle M Townsley1, Yasutaka Ueda1, Tetsuichi Yoshizato2, Rodrigo T Calado3, Yanqin Yang4, Yoshiyuki Wakabayashi4, Sachiko Kajigaya1, Seishi Ogawa2, Jun Zhu4, Neal S Young1

Author Affiliations

1: Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD;
2: Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan;
3: Department of Internal Medicine, University of São Paulo at Ribeirão Preto Medical School, Ribeirão Preto, SP, Brazil; and.
4: DNA Sequencing and Computational Biology Core, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.

Articles cited by this

Clinical effect of point mutations in myelodysplastic syndromes. N Engl J Med (2011) 9.90

The origin and evolution of mutations in acute myeloid leukemia. Cell (2012) 9.66

Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. N Engl J Med (2005) 7.09

Telomeres and telomerase in cancer. Carcinogenesis (2009) 4.28

Landscape of genetic lesions in 944 patients with myelodysplastic syndromes. Leukemia (2013) 3.93

Antithymocyte globulin and cyclosporine for severe aplastic anemia: association between hematologic response and long-term outcome. JAMA (2003) 3.90

Extensive allelic variation and ultrashort telomeres in senescent human cells. Nat Genet (2003) 3.77

Telomere dysfunction and tumour suppression: the senescence connection. Nat Rev Cancer (2008) 2.54

How I treat acquired aplastic anemia. Blood (2012) 2.44

Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells. Blood (2009) 2.12

The problem of clonality in aplastic anemia: Dr Dameshek's riddle, restated. Blood (1992) 1.99

MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia. Cancer Cell (2014) 1.98

Association of telomere length of peripheral blood leukocytes with hematopoietic relapse, malignant transformation, and survival in severe aplastic anemia. JAMA (2010) 1.86

Somatic mutations identify a subgroup of aplastic anemia patients who progress to myelodysplastic syndrome. Blood (2014) 1.82

Telomere-related genome instability in cancer. Cold Spring Harb Symp Quant Biol (2005) 1.69

Late clonal diseases of treated aplastic anemia. Semin Hematol (2000) 1.27

Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia. Leukemia (2011) 1.21

Low frequency clonal mutations recoverable by deep sequencing in patients with aplastic anemia. Leukemia (2013) 1.14

Recurrent genetic defects on chromosome 7q in myeloid neoplasms. Leukemia (2014) 0.91

Genetic characterization of acquired aplastic anemia by targeted sequencing. Haematologica (2014) 0.87