Published in J Biomech Eng on January 26, 2015
A Review of Cell Adhesion Studies for Biomedical and Biological Applications. Int J Mol Sci (2015) 0.91
Microfabricated tissues for investigating traction forces involved in cell migration and tissue morphogenesis. Cell Mol Life Sci (2016) 0.75
Matrix elasticity directs stem cell lineage specification. Cell (2006) 43.00
Cell locomotion and focal adhesions are regulated by substrate flexibility. Proc Natl Acad Sci U S A (1997) 19.46
Tensional homeostasis and the malignant phenotype. Cancer Cell (2005) 19.30
Cells lying on a bed of microneedles: an approach to isolate mechanical force. Proc Natl Acad Sci U S A (2003) 11.53
Stresses at the cell-to-substrate interface during locomotion of fibroblasts. Biophys J (1999) 10.71
Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion. Cell Motil Cytoskeleton (2005) 10.20
Silicone rubber substrata: a new wrinkle in the study of cell locomotion. Science (1980) 9.81
Cell adhesion: integrating cytoskeletal dynamics and cellular tension. Nat Rev Mol Cell Biol (2010) 7.27
Substrate elasticity regulates skeletal muscle stem cell self-renewal in culture. Science (2010) 6.67
Direct observation of catch bonds involving cell-adhesion molecules. Nature (2003) 6.30
Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics. Nature (2010) 6.25
Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase. Science (1997) 5.80
Mechanically activated integrin switch controls alpha5beta1 function. Science (2009) 4.94
Integrin ligands at a glance. J Cell Sci (2006) 4.76
Mechanical regulation of cell function with geometrically modulated elastomeric substrates. Nat Methods (2010) 4.74
A micromachined device provides a new bend on fibroblast traction forces. Proc Natl Acad Sci U S A (1997) 4.50
High resolution traction force microscopy based on experimental and computational advances. Biophys J (2007) 3.89
A distinctive role for focal adhesion proteins in three-dimensional cell motility. Nat Cell Biol (2010) 3.84
Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin. Nature (2003) 3.70
Vinculin knockout results in heart and brain defects during embryonic development. Development (1998) 3.44
Measurement of mechanical tractions exerted by cells in three-dimensional matrices. Nat Methods (2010) 3.35
Material properties of the cell dictate stress-induced spreading and differentiation in embryonic stem cells. Nat Mater (2009) 3.30
Demonstration of catch bonds between an integrin and its ligand. J Cell Biol (2009) 3.26
Mechanical switching and coupling between two dissociation pathways in a P-selectin adhesion bond. Proc Natl Acad Sci U S A (2004) 3.11
Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrix. Science (2014) 2.98
Effect of flow on polymorphonuclear leukocyte/endothelial cell adhesion. Blood (1987) 2.97
Deconstructing the third dimension: how 3D culture microenvironments alter cellular cues. J Cell Sci (2012) 2.89
Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels. Nat Mater (2013) 2.84
The dynamics and mechanics of endothelial cell spreading. Biophys J (2005) 2.76
Surface chemistry modulates fibronectin conformation and directs integrin binding and specificity to control cell adhesion. J Biomed Mater Res A (2003) 2.66
Design and construction of a linear shear stress flow chamber. Ann Biomed Eng (1993) 2.57
Forces in tissue morphogenesis and patterning. Cell (2013) 2.55
Clustering of alpha(5)beta(1) integrins determines adhesion strength whereas alpha(v)beta(3) and talin enable mechanotransduction. Proc Natl Acad Sci U S A (2009) 2.52
Adhesive interactions of leukocytes, platelets, and the vessel wall during hemostasis and inflammation. Thromb Haemost (2001) 2.51
Cell adhesion strengthening: contributions of adhesive area, integrin binding, and focal adhesion assembly. Mol Biol Cell (2005) 2.51
PECAM-1: a multi-functional molecule in inflammation and vascular biology. Arterioscler Thromb Vasc Biol (2007) 2.46
Defining single molecular forces required to activate integrin and notch signaling. Science (2013) 2.44
Age-related intimal stiffening enhances endothelial permeability and leukocyte transmigration. Sci Transl Med (2011) 2.35
Vascular smooth muscle cell durotaxis depends on substrate stiffness gradient strength. Biophys J (2009) 2.34
Substrate stiffness regulates cadherin-dependent collective migration through myosin-II contractility. J Cell Biol (2012) 2.33
Receptor-mediated adhesion phenomena. Model studies with the Radical-Flow Detachment Assay. Biophys J (1990) 2.30
Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. Sci Signal (2009) 2.26
Intercellular recognition: quantitation of initial binding events. Proc Natl Acad Sci U S A (1981) 2.24
Fluid shear stress on endothelial cells modulates mechanical tension across VE-cadherin and PECAM-1. Curr Biol (2013) 2.02
Evidence of a large-scale mechanosensing mechanism for cellular adaptation to substrate stiffness. Proc Natl Acad Sci U S A (2012) 1.94
Interplay of matrix stiffness and protein tethering in stem cell differentiation. Nat Mater (2014) 1.80
3D Traction forces in cancer cell invasion. PLoS One (2012) 1.76
Reducing background fluorescence reveals adhesions in 3D matrices. Nat Cell Biol (2011) 1.69
Quantifying cell-generated mechanical forces within living embryonic tissues. Nat Methods (2013) 1.64
Traction forces exerted by epithelial cell sheets. J Phys Condens Matter (2010) 1.60
Assaying stem cell mechanobiology on microfabricated elastomeric substrates with geometrically modulated rigidity. Nat Protoc (2011) 1.60
Multidimensional traction force microscopy reveals out-of-plane rotational moments about focal adhesions. Proc Natl Acad Sci U S A (2012) 1.59
Microfabricated silicone elastomeric post arrays for measuring traction forces of adherent cells. Methods Cell Biol (2007) 1.56
Substrate Stiffness and Cell Area Predict Cellular Traction Stresses in Single Cells and Cells in Contact. Cell Mol Bioeng (2010) 1.55
How vinculin regulates force transmission. Proc Natl Acad Sci U S A (2013) 1.51
Cellular traction stresses increase with increasing metastatic potential. PLoS One (2012) 1.50
Force required to break alpha5beta1 integrin-fibronectin bonds in intact adherent cells is sensitive to integrin activation state. J Biol Chem (1998) 1.46
Binding strength and activation state of single fibrinogen-integrin pairs on living cells. Proc Natl Acad Sci U S A (2002) 1.44
The role of the cytoskeleton in cellular force generation in 2D and 3D environments. Phys Biol (2011) 1.32
Three-dimensional cell migration does not follow a random walk. Proc Natl Acad Sci U S A (2014) 1.30
Decoupling substrate stiffness, spread area, and micropost density: a close spatial relationship between traction forces and focal adhesions. Biophys J (2012) 1.30
Quantification of cell adhesion using a spinning disc device and application to surface-reactive materials. Biomaterials (1997) 1.29
Mechanical forces induced by the transendothelial migration of human neutrophils. Biophys J (2008) 1.28
Development and use of a parallel-plate flow chamber for studying cellular adhesion to solid surfaces. J Biomed Mater Res (1992) 1.25
The effects of surface chemistry and adsorbed proteins on monocyte/macrophage adhesion to chemically modified polystyrene surfaces. J Biomed Mater Res (2001) 1.23
Tuning three-dimensional collagen matrix stiffness independently of collagen concentration modulates endothelial cell behavior. Acta Biomater (2012) 1.22
Adhesion of red cells to foreign surfaces in the presence of flow. J Biomed Mater Res (1974) 1.19
Dynamic force spectroscopy to probe adhesion strength of living cells. Phys Rev Lett (2002) 1.16
Adhesion strength-based, label-free isolation of human pluripotent stem cells. Nat Methods (2013) 1.12
Theoretical and experimental studies on cross-bridge migration during cell disaggregation. Biophys J (1989) 1.09
A novel mode of cell detachment from fibrillar fibronectin matrix under shear. J Cell Sci (2009) 1.08
Nanopatterning reveals an ECM area threshold for focal adhesion assembly and force transmission that is regulated by integrin activation and cytoskeleton tension. J Cell Sci (2012) 1.07
A centrifugation cell adhesion assay for high-throughput screening of biomaterial surfaces. J Biomed Mater Res A (2003) 1.07
Cyclic mechanical reinforcement of integrin-ligand interactions. Mol Cell (2013) 1.05
Stick and grip: measurement systems and quantitative analyses of integrin-mediated cell adhesion strength. Cell Biochem Biophys (2003) 1.05
Flow mechanotransduction regulates traction forces, intercellular forces, and adherens junctions. Am J Physiol Heart Circ Physiol (2012) 1.04
Tension sensing nanoparticles for mechano-imaging at the living/nonliving interface. J Am Chem Soc (2013) 1.04
High-resolution traction force microscopy. Methods Cell Biol (2014) 1.02
Mesenchymal stem cells ability to generate traction stress in response to substrate stiffness is modulated by the changing extracellular matrix composition of the heart during development. Biochem Biophys Res Commun (2013) 1.01
Mesenchymal stem cells exploit extracellular matrix as mechanotransducer. Sci Rep (2013) 1.00
Cell biology. Deconstructing dimensionality. Science (2013) 0.98
An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration. Nat Cell Biol (2014) 0.98
Dual delivery of hepatocyte and vascular endothelial growth factors via a protease-degradable hydrogel improves cardiac function in rats. PLoS One (2012) 0.93
The effects of substrate elasticity on endothelial cell network formation and traction force generation. Conf Proc IEEE Eng Med Biol Soc (2009) 0.92
Effect of fibronectin amount and conformation on the strength of endothelial cell adhesion to HEMA/EMA copolymers. J Biomed Mater Res (1996) 0.92
Interaction of neoplastic cells with glass surface under flow conditions. Exp Cell Res (1977) 0.91
The effect of fluid shear stress upon cell adhesion to fibronectin-treated surfaces. J Biomed Mater Res (1990) 0.89
Substrate Stiffness Regulates PDGF-Induced Circular Dorsal Ruffle Formation Through MLCK. Cell Mol Bioeng (2013) 0.87
Measurement of fibroblast and bacterial detachment from biomaterials using jet impingement. Cell Biol Int (2001) 0.82
Quantitative analyses of cell adhesion strength. Methods Mol Biol (2007) 0.81
Cell adhesion strengthening: measurement and analysis. Methods Cell Biol (2007) 0.79
Micropatterning on micropost arrays. Methods Cell Biol (2014) 0.78
Measuring cell-cell tugging forces using bowtie-patterned mPADs (microarray post detectors). Methods Mol Biol (2013) 0.78
Controlling the mechanical properties of three-dimensional matrices via non-enzymatic collagen glycation. Organogenesis (2013) 0.77
Demonstration of catch bonds between an integrin and its ligand. J Cell Biol (2009) 3.26
Integrin binding specificity regulates biomaterial surface chemistry effects on cell differentiation. Proc Natl Acad Sci U S A (2005) 2.88
Surface chemistry modulates fibronectin conformation and directs integrin binding and specificity to control cell adhesion. J Biomed Mater Res A (2003) 2.66
Cell adhesion strengthening: contributions of adhesive area, integrin binding, and focal adhesion assembly. Mol Biol Cell (2005) 2.51
Unique morphology and focal adhesion development of valvular endothelial cells in static and fluid flow environments. Arterioscler Thromb Vasc Biol (2004) 2.28
Male fertility and sex ratio at birth in red deer. Science (2006) 2.22
Surface chemistry modulates focal adhesion composition and signaling through changes in integrin binding. Biomaterials (2004) 2.06
Bioartificial matrices for therapeutic vascularization. Proc Natl Acad Sci U S A (2009) 1.99
Integrin specificity and enhanced cellular activities associated with surfaces presenting a recombinant fibronectin fragment compared to RGD supports. Biomaterials (2006) 1.86
Engineering graded tissue interfaces. Proc Natl Acad Sci U S A (2008) 1.69
Male fertility in natural populations of red deer is determined by sperm velocity and the proportion of normal spermatozoa. Biol Reprod (2004) 1.61
Focal adhesion kinase modulates cell adhesion strengthening via integrin activation. Mol Biol Cell (2009) 1.60
Effects of medium perfusion rate on cell-seeded three-dimensional bone constructs in vitro. Tissue Eng (2003) 1.52
How vinculin regulates force transmission. Proc Natl Acad Sci U S A (2013) 1.51
Benefits for dominant red deer hinds under a competitive feeding system: food access behavior, diet and nutrient selection. PLoS One (2012) 1.47
Inhibition of in vitro chondrogenesis in RGD-modified three-dimensional alginate gels. Biomaterials (2006) 1.44
Maleimide cross-linked bioactive PEG hydrogel exhibits improved reaction kinetics and cross-linking for cell encapsulation and in situ delivery. Adv Mater (2011) 1.43
The effect of integrin-specific bioactive coatings on tissue healing and implant osseointegration. Biomaterials (2008) 1.41
Combinatorial characterization of cell interactions with polymer surfaces. J Biomed Mater Res A (2003) 1.41
Effects of protein dose and delivery system on BMP-mediated bone regeneration. Biomaterials (2011) 1.38
Biomolecular surface coating to enhance orthopaedic tissue healing and integration. Biomaterials (2007) 1.37
Myoblast alignment and differentiation on cell culture substrates with microscale topography and model chemistries. Biomaterials (2007) 1.34
Contractility modulates cell adhesion strengthening through focal adhesion kinase and assembly of vinculin-containing focal adhesions. J Cell Physiol (2010) 1.29
Human stem cell delivery for treatment of large segmental bone defects. Proc Natl Acad Sci U S A (2010) 1.28
Combined microscale mechanical topography and chemical patterns on polymer cell culture substrates. Biomaterials (2005) 1.28
Interactions between integrin ligand density and cytoskeletal integrity regulate BMSC chondrogenesis. J Cell Physiol (2008) 1.27
Myoblast proliferation and differentiation on fibronectin-coated self assembled monolayers presenting different surface chemistries. Biomaterials (2004) 1.25
Synthesis and modification of functional poly(lactide) copolymers: toward biofunctional materials. Biomacromolecules (2008) 1.23
Coating of biomaterial scaffolds with the collagen-mimetic peptide GFOGER for bone defect repair. Biomaterials (2009) 1.23
Engineering integrin-specific surfaces with a triple-helical collagen-mimetic peptide. J Biomed Mater Res A (2003) 1.23
Phase transition behavior, protein adsorption, and cell adhesion resistance of poly(ethylene glycol) cross-linked microgel particles. Biomacromolecules (2005) 1.21
Cell-type-dependent up-regulation of in vitro mineralization after overexpression of the osteoblast-specific transcription factor Runx2/Cbfal. J Bone Miner Res (2002) 1.21
Alpha2beta1 integrin-specific collagen-mimetic surfaces supporting osteoblastic differentiation. J Biomed Mater Res A (2004) 1.20
Specific beta1 integrins mediate adhesion, migration, and differentiation of neural progenitors derived from the embryonic striatum. Mol Cell Neurosci (2004) 1.17
Facile preparation of complex protein architectures with sub-100-nm resolution on surfaces. Angew Chem Int Ed Engl (2007) 1.17
Multivalent integrin-specific ligands enhance tissue healing and biomaterial integration. Sci Transl Med (2010) 1.16
Human mesenchymal stem cell differentiation on self-assembled monolayers presenting different surface chemistries. Acta Biomater (2009) 1.16
Engineering more than a cell: vascularization strategies in tissue engineering. Curr Opin Biotechnol (2010) 1.15
Adhesion strength-based, label-free isolation of human pluripotent stem cells. Nat Methods (2013) 1.12
Quantitative methods for analysis of integrin binding and focal adhesion formation on biomaterial surfaces. Biomaterials (2005) 1.11
Glucocorticoid-induced osteogenesis is negatively regulated by Runx2/Cbfa1 serine phosphorylation. J Cell Sci (2006) 1.11
Exogenous Runx2 expression enhances in vitro osteoblastic differentiation and mineralization in primary bone marrow stromal cells. Tissue Eng (2005) 1.08
Nanopatterning reveals an ECM area threshold for focal adhesion assembly and force transmission that is regulated by integrin activation and cytoskeleton tension. J Cell Sci (2012) 1.07
Vasculogenic bio-synthetic hydrogel for enhancement of pancreatic islet engraftment and function in type 1 diabetes. Biomaterials (2013) 1.07
A centrifugation cell adhesion assay for high-throughput screening of biomaterial surfaces. J Biomed Mater Res A (2003) 1.07
Engineering cell adhesive surfaces that direct integrin alpha5beta1 binding using a recombinant fragment of fibronectin. Biomaterials (2003) 1.06
Runx2/Cbfa1 stimulates transdifferentiation of primary skeletal myoblasts into a mineralizing osteoblastic phenotype. Exp Cell Res (2004) 1.06
Model of integrin-mediated cell adhesion strengthening. J Biomech (2006) 1.06
Role of plasma fibronectin in the foreign body response to biomaterials. Biomaterials (2007) 1.05
Cyclic mechanical reinforcement of integrin-ligand interactions. Mol Cell (2013) 1.05
Bioadhesive hydrogel microenvironments to modulate epithelial morphogenesis. Biomaterials (2008) 1.04
Mineralization capacity of Runx2/Cbfa1-genetically engineered fibroblasts is scaffold dependent. Biomaterials (2006) 1.03
Functional lactide monomers: methodology and polymerization. Biomacromolecules (2006) 1.03
Virus-based gene therapy strategies for bone regeneration. Biomaterials (2006) 1.01
Well-defined Poly(lactic acid)s Containing Poly(ethylene glycol) Side-chains. Macromolecules (2012) 1.01
Self-assembling nanoparticles for intra-articular delivery of anti-inflammatory proteins. Biomaterials (2012) 1.00
Triggered cell release from materials using bioadhesive photocleavable linkers. Adv Mater (2011) 0.99
Extracellular matrix-mimetic adhesive biomaterials for bone repair. J Biomed Mater Res A (2010) 0.99
Enhanced expression of the osteoblastic phenotype on substrates that modulate fibronectin conformation and integrin receptor binding. Biomaterials (2002) 0.97
Role of fibronectin in topographical guidance of neurite extension on electrospun fibers. Biomaterials (2011) 0.96
Role of material-driven fibronectin fibrillogenesis in cell differentiation. Biomaterials (2010) 0.96
Genetic engineering for skeletal regenerative medicine. Annu Rev Biomed Eng (2007) 0.95
Thermoreversible laminin-functionalized hydrogel for neural tissue engineering. J Biomed Mater Res A (2006) 0.95
Oscillatory tension differentially modulates matrix metabolism and cytoskeletal organization in chondrocytes and fibrochondrocytes. J Biomech (2004) 0.95
Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins. Proc Natl Acad Sci U S A (2013) 0.94
Effects of Runx2 genetic engineering and in vitro maturation of tissue-engineered constructs on the repair of critical size bone defects. J Biomed Mater Res A (2006) 0.94
Centrifugal deposition of microgels for the rapid assembly of nonfouling thin films. ACS Appl Mater Interfaces (2009) 0.93
Dual delivery of hepatocyte and vascular endothelial growth factors via a protease-degradable hydrogel improves cardiac function in rats. PLoS One (2012) 0.93
Reduced acute inflammatory responses to microgel conformal coatings. Biomaterials (2008) 0.93
Minimally invasive, longitudinal monitoring of biomaterial-associated inflammation by fluorescence imaging. Biomaterials (2011) 0.93
Simple application of fibronectin-mimetic coating enhances osseointegration of titanium implants. J Cell Mol Med (2008) 0.92
Covalent tethering of functional microgel films onto poly(ethylene terephthalate) surfaces. Biomacromolecules (2007) 0.92
Cadherin-mediated cell-cell contact regulates keratinocyte differentiation. J Invest Dermatol (2008) 0.92
Mixed extracellular matrix ligands synergistically modulate integrin adhesion and signaling. J Cell Physiol (2008) 0.91
p120-catenin and β-catenin differentially regulate cadherin adhesive function. Mol Biol Cell (2013) 0.91
Plasma fibronectin is neuroprotective following traumatic brain injury. Exp Neurol (2007) 0.91
Microfluidic-based generation of size-controlled, biofunctionalized synthetic polymer microgels for cell encapsulation. Adv Mater (2014) 0.90
Biomaterial-mediated retroviral gene transfer using self-assembled monolayers. Biomaterials (2007) 0.89
Dermal fibroblasts genetically modified to express Runx2/Cbfa1 as a mineralizing cell source for bone tissue engineering. Tissue Eng (2007) 0.88
A FAK/Src chimera with gain-of-function properties promotes formation of large peripheral adhesions associated with dynamic actin assembly. Cell Motil Cytoskeleton (2008) 0.87
Anti-inflammatory polymeric coatings for implantable biomaterials and devices. J Diabetes Sci Technol (2008) 0.87
Identification of novel Runx2 targets in osteoblasts: cell type-specific BMP-dependent regulation of Tram2. J Cell Biochem (2007) 0.87
Biomimetic microenvironment modulates neural stem cell survival, migration, and differentiation. Tissue Eng Part A (2010) 0.87
Polymer brushes and self-assembled monolayers: Versatile platforms to control cell adhesion to biomaterials (Review). Biointerphases (2009) 0.86
Quantitative high-throughput screening of osteoblast attachment, spreading, and proliferation on demixed polymer blend micropatterns. Biomacromolecules (2007) 0.86
Physiological variables explain mineral intake in Iberian red deer. Physiol Behav (2010) 0.86
Dynamic cell-adhesive microenvironments and their effect on myogenic differentiation. Acta Biomater (2013) 0.86
Can Iberian red deer (Cervus elaphus hispanicus) discriminate among essential minerals in their diet? Br J Nutr (2009) 0.86
Direct versus indirect effects of social rank, maternal weight, body condition and age on milk production in Iberian red deer ( Cervus elaphus hispanicus). J Dairy Res (2009) 0.85
CIM(®) monolithic anion-exchange chromatography as a useful alternative to CsCl gradient purification of bacteriophage particles. Virology (2012) 0.85
Chronic inflammatory responses to microgel-based implant coatings. J Biomed Mater Res A (2010) 0.84
Synergy between genetic and tissue engineering: Runx2 overexpression and in vitro construct development enhance in vivo mineralization. Tissue Eng (2005) 0.84
Profiles of carbohydrate ligands associated with adsorbed proteins on self-assembled monolayers of defined chemistries. J Biomed Mater Res A (2010) 0.84
Effects of thawing procedure on postthawed in vitro viability and in vivo fertility of red deer epididymal spermatozoa cryopreserved at -196 degrees C. J Androl (2003) 0.84
Protein tethering into multiscale geometries by covalent subtractive printing. Adv Mater (2011) 0.83
Surface functionalization of polyketal microparticles with nitrilotriacetic acid-nickel complexes for efficient protein capture and delivery. Biomaterials (2010) 0.83
In vitro and in vivo osteoblastic differentiation of BMP-2- and Runx2-engineered skeletal myoblasts. J Cell Biochem (2007) 0.83
Dendritic cell responses to self-assembled monolayers of defined chemistries. J Biomed Mater Res A (2010) 0.82
Micro- and nano-patterned substrates to manipulate cell adhesion. J Nanosci Nanotechnol (2007) 0.82
Engineered VEGF-releasing PEG-MAL hydrogel for pancreatic islet vascularization. Drug Deliv Transl Res (2015) 0.82