Published in PLoS One on December 04, 2014
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WT1 expression in the human fetus during development. Eur J Histochem (2015) 0.78
Expression profile of Wilms Tumor 1 (WT1) isoforms in undifferentiated and all-trans retinoic acid differentiated neuroblastoma cells. Genes Cancer (2016) 0.76
Wilms' tumor gene 1 silencing inhibits proliferation of human osteosarcoma MG-63 cell line by cell cycle arrest and apoptosis activation. Oncotarget (2017) 0.75
The phosphoinositide 3-kinase pathway. Science (2002) 24.72
Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus. Cell (1990) 8.30
Minireview: Cyclin D1: normal and abnormal functions. Endocrinology (2004) 5.22
Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping. Nature (1990) 5.13
Malignant peripheral nerve sheath tumours in neurofibromatosis 1. J Med Genet (2002) 5.06
The NF1 tumor suppressor critically regulates TSC2 and mTOR. Proc Natl Acad Sci U S A (2005) 3.49
Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance. Adv Enzyme Regul (2006) 3.32
A tumor suppressor and oncogene: the WT1 story. Leukemia (2007) 2.81
Cyclin D1: polymorphism, aberrant splicing and cancer risk. Oncogene (2006) 2.57
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The many facets of the Wilms' tumour gene, WT1. Hum Mol Genet (2006) 2.10
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WT1 proteins: functions in growth and differentiation. Gene (2001) 1.82
The expression of WT1 in the differentiation of rhabdomyosarcoma from other pediatric small round blue cell tumors. Mod Pathol (2002) 1.79
Wilms' tumor suppressor gene (WT1) is expressed in primary breast tumors despite tumor-specific promoter methylation. Cancer Res (2001) 1.73
Malignant Peripheral Nerve Sheath Tumor: molecular pathogenesis and current management considerations. J Surg Oncol (2008) 1.64
Immunohistochemical detection of WT1 protein in a variety of cancer cells. Mod Pathol (2006) 1.62
Expression of the Wilms' tumor gene (WT1) in human leukemias. Leukemia (1992) 1.60
Wilms tumor and the WT1 gene. Exp Cell Res (2001) 1.49
Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors. Mol Cancer Ther (2008) 1.44
Dual targeting of AKT and mammalian target of rapamycin: a potential therapeutic approach for malignant peripheral nerve sheath tumor. Mol Cancer Ther (2009) 1.33
Overexpression of the Wilms' tumor gene WT1 in de novo lung cancers. Int J Cancer (2002) 1.32
Malignant peripheral nerve sheath tumour (MPNST): the clinical implications of cellular signalling pathways. Expert Rev Mol Med (2009) 1.28
Cathepsin D mediates cytochrome c release and caspase activation in human fibroblast apoptosis induced by staurosporine. Cell Death Differ (2003) 1.28
The Wilms' tumour protein (WT1) shuttles between nucleus and cytoplasm and is present in functional polysomes. Hum Mol Genet (2003) 1.26
Transcriptional regulation by WT1 in development. Curr Opin Genet Dev (2005) 1.19
WT1 (Wilms' tumor gene 1): biology and cancer immunotherapy. Jpn J Clin Oncol (2010) 1.15
Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis. Hum Mol Genet (2010) 1.14
The complex life of WT1. J Cell Sci (2003) 1.13
UVA-induced cell cycle progression is mediated by a disintegrin and metalloprotease/epidermal growth factor receptor/AKT/Cyclin D1 pathways in keratinocytes. Cancer Res (2008) 1.12
Notch and Schwann cell transformation. Oncogene (2004) 1.08
HER2/neu increases the expression of Wilms' Tumor 1 (WT1) protein to stimulate S-phase proliferation and inhibit apoptosis in breast cancer cells. Oncogene (2005) 1.07
Wilms' tumor gene WT1-shRNA as a potent apoptosis-inducing agent for solid tumors. Int J Oncol (2008) 1.04
Molecular mechanisms promoting the pathogenesis of Schwann cell neoplasms. Acta Neuropathol (2011) 1.04
Overexpression of the Wilms' tumor gene W T1 in primary astrocytic tumors. Cancer Sci (2004) 1.02
Transcriptional profiling in an MPNST-derived cell line and normal human Schwann cells. Neuron Glia Biol (2004) 1.02
Genetic basis of tumorigenesis in NF1 malignant peripheral nerve sheath tumors. Front Biosci (Landmark Ed) (2011) 1.02
Overexpression of the Wilms' tumor gene WT1 in pancreatic ductal adenocarcinoma. Cancer Sci (2004) 1.01
A splice variant of the Wilms' tumour suppressor Wt1 is required for normal development of the olfactory system. Development (2005) 1.00
The Wilms' tumor 1 gene: oncogene or tumor suppressor gene? Int Rev Cytol (1998) 0.99
Wilms' tumor 1 and signal transducers and activators of transcription 3 synergistically promote cell proliferation: a possible mechanism in sporadic Wilms' tumor. Cancer Res (2006) 0.98
Molecular evolution of a neurofibroma to malignant peripheral nerve sheath tumor (MPNST) in an NF1 patient: correlation between histopathological, clinical and molecular findings. J Cancer Res Clin Oncol (2010) 0.96
EGFR-STAT3 signaling promotes formation of malignant peripheral nerve sheath tumors. Oncogene (2013) 0.94
Overexpression of the Wilms' tumor gene WT1 in human bone and soft-tissue sarcomas. Cancer Sci (2003) 0.94
WT1 gene silencing by aerosol delivery of PEI-RNAi complexes inhibits B16-F10 lung metastases growth. Cancer Gene Ther (2009) 0.93
A WT1 antisense oligonucleotide inhibits proliferation and induces apoptosis in myeloid leukaemia cell lines. Oncogene (1996) 0.93
Wilms' tumor gene WT1 17AA(-)/KTS(-) isoform induces morphological changes and promotes cell migration and invasion in vitro. Cancer Sci (2006) 0.91
Downregulation of Wilms' tumor 1 protein inhibits breast cancer proliferation. Biochem Biophys Res Commun (2002) 0.91
WT1 is a tumor-associated antigen in colon cancer that can be recognized by in vitro stimulated cytotoxic T cells. Int J Cancer (2004) 0.91
The Wilms' tumor gene product WT1 mediates the down-regulation of the rat epidermal growth factor receptor by nerve growth factor in PC12 cells. J Biol Chem (2000) 0.90
Upregulation of Wilms' tumor gene 1 (WT1) in desmoid tumors. Int J Cancer (2005) 0.89
PI-3K/Akt signal pathway plays a crucial role in arsenite-induced cell proliferation of human keratinocytes through induction of cyclin D1. J Cell Biochem (2007) 0.89
The Wilms' tumor suppressor WT1 is associated with melanoma proliferation. Pflugers Arch (2007) 0.88
WT1 influences apoptosis through transcriptional regulation of Bcl-2 family members. Cell Cycle (2006) 0.87
The role of the Wilms' tumour-suppressor protein WT1 in apoptosis. Biochem Soc Trans (2008) 0.86
Cyclin E is a target of WT1 transcriptional repression. J Biol Chem (2002) 0.86
WT1 promotes cell proliferation in non-small cell lung cancer cell lines through up-regulating cyclin D1 and p-pRb in vitro and in vivo. PLoS One (2013) 0.86
Delayed rectifier K currents in NF1 Schwann cells. Pharmacological block inhibits proliferation. Neurobiol Dis (2003) 0.86
Immunohistochemical expression of Wilms' tumor protein (WT1) in developing human epithelial and mesenchymal tissues. Acta Histochem (2012) 0.85
RNAi silencing of the WT1 gene inhibits cell proliferation and induces apoptosis in the B16F10 murine melanoma cell line. Melanoma Res (2007) 0.84
The Wilms' tumor suppressor Wt1 is associated with the differentiation of retinoblastoma cells. Cell Growth Differ (2002) 0.83
Wilms' tumor suppressor (WT1) is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer's disease. Brain Res (2003) 0.83
WT1 expression in normal and neoplastic cranial and peripheral nerves is independent of grade of malignancy. Cancer Biomark (2010) 0.82
Growth inhibition of breast cancer cell line MCF-7 by siRNA silencing of Wilms tumor 1 gene. J Med Assoc Thai (2007) 0.82
Regulation of gene expression by WT1 in development and tumorigenesis. Int J Hematol (2002) 0.81
Wilms' tumor 1 silencing decreases the viability and chemoresistance of glioblastoma cells in vitro: a potential role for IGF-1R de-repression. J Neurooncol (2010) 0.81
Wilms' tumour suppressor gene 1 (WT1) is involved in the carcinogenesis of Lung cancer through interaction with PI3K/Akt pathway. Cancer Cell Int (2013) 0.81
NF1 deficiency causes Bcl-xL upregulation in Schwann cells derived from neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors. Int J Oncol (2012) 0.81
The role of WT1 gene in neuroblastoma. J Pediatr Surg (2011) 0.80
Immunolocalization of Wilms' Tumor protein (WT1) in developing human peripheral sympathetic and gastroenteric nervous system. Acta Histochem (2013) 0.80
Actin: a novel interaction partner of WT1 influencing its cell dynamic properties. Oncogene (2009) 0.79
Wilms tumor-1, claudin-1 and ezrin are useful immunohistochemical markers that help to distinguish schwannoma from fibroblastic meningioma. Pathol Oncol Res (2011) 0.79
WT1 silencing by RNAi synergizes with chemotherapeutic agents and induces chemosensitization to doxorubicin and cisplatin in B16F10 murine melanoma cells. Oncol Lett (2012) 0.78
The modulation of WTI transcription function by cofactors. Biochem Soc Symp (2006) 0.78
The possible role and application of WT1 in human leukemia. Int J Hematol (2001) 0.77
Expression of Wilms tumor 1 gene in a variety of pediatric tumors. J Pediatr Surg (2011) 0.77
Wilms' tumor protein (WT1) in mammary myofibroblastoma: an immunohistochemical study. Acta Histochem (2014) 0.77
WT1 protein expression in astrocytic tumors and its relationship with cellular proliferation index. Adv Biomed Res (2013) 0.77
Effect of WT1 gene silencing on the tumorigenicity of human glioblastoma multiforme cells. J Neurosurg (2010) 0.76