Hepatitis C virus NS5A: enigmatic but still promiscuous 10 years on!

Direct-acting antiviral agents for hepatitis C: structural and mechanistic insights. Nat Rev Gastroenterol Hepatol (2016) 0.88

Pim Kinase Interacts with Nonstructural 5A Protein and Regulates Hepatitis C Virus Entry. J Virol (2015) 0.86

The Combination of Grazoprevir, a Hepatitis C Virus (HCV) NS3/4A Protease Inhibitor, and Elbasvir, an HCV NS5A Inhibitor, Demonstrates a High Genetic Barrier to Resistance in HCV Genotype 1a Replicons. Antimicrob Agents Chemother (2016) 0.82

NS5A Domain 1 and Polyprotein Cleavage Kinetics Are Critical for Induction of Double-Membrane Vesicles Associated with Hepatitis C Virus Replication. MBio (2015) 0.82

Hepatitis C virus RNA replication depends on specific cis- and trans-acting activities of viral nonstructural proteins. PLoS Pathog (2015) 0.80

Phosphoproteomics Identified an NS5A Phosphorylation Site Involved in Hepatitis C Virus Replication. J Biol Chem (2015) 0.79

Preclinical Profile and Clinical Efficacy of a Novel Hepatitis C Virus NS5A Inhibitor, EDP-239. Antimicrob Agents Chemother (2016) 0.79

Vinexin β Interacts with Hepatitis C Virus NS5A, Modulating Its Hyperphosphorylation To Regulate Viral Propagation. J Virol (2015) 0.78

Hepatitis C Virus Particle Assembly Involves Phosphorylation of NS5A by the c-Abl Tyrosine Kinase. J Biol Chem (2015) 0.78

Phosphorylation of Serine 235 of the Hepatitis C Virus Non-Structural Protein NS5A by Multiple Kinases. PLoS One (2016) 0.78

Hepatitis C virus NS5A protein blocks epidermal growth factor receptor degradation via a proline motif- dependent interaction. J Gen Virol (2015) 0.77

Serine 235 Is the Primary NS5A Hyper-Phosphorylation Site Responsible for HCV Replication. J Virol (2017) 0.76

ISG12a Restricts Hepatitis C Virus Infection through the Ubiquitination-Dependent Degradation Pathway. J Virol (2016) 0.75

Nonstructural 5A Protein of Hepatitis C Virus Interferes with Toll-Like Receptor Signaling and Suppresses the Interferon Response in Mouse Liver. PLoS One (2017) 0.75

Allosteric heat shock protein 70 inhibitors block hepatitis C virus assembly. Int J Antimicrob Agents (2016) 0.75

Functional evaluation of synthetic flavonoids and chalcones for potential antiviral and anticancer properties. Bioorg Med Chem Lett (2017) 0.75

Hepatitis C Virus Subverts Human Choline Kinase-α to Bridge PI4KIIIα and NS5A and Upregulates PI4KIIIα Activation, Thereby Promoting the Translocation of the Ternary Complex to the ER for Viral Replication. J Virol (2017) 0.75

Hepatitis C virus NS5A targets the nucleosome assembly protein NAP1L1 to control the innate cellular response. J Virol (2017) 0.75