Antagonism of human CC-chemokine receptor 4 can be achieved through three distinct binding sites on the receptor.

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Published in Pharmacol Res Perspect on December 30, 2013

Authors

Robert J Slack1, Linda J Russell1, Nick P Barton2, Cathryn Weston1, Giovanna Nalesso1, Sally-Anne Thompson1, Morven Allen3, Yu Hua Chen3, Ashley Barnes3, Simon T Hodgson4, David A Hall1

Author Affiliations

1: Lead Optimisation, Respiratory CEDD, GlaxoSmithKline Gunnels Wood Road, Stevenage, Herts, SG1 2NY, UK.
2: Computational Chemistry, GlaxoSmithKline Gunnels Wood Road, Stevenage, Herts, SG1 2NY, UK.
3: Biological Reagents and Assay Development, GlaxoSmithKline Gunnels Wood Road, Stevenage, Herts, SG1 2NY, UK.
4: Medicinal Chemistry, Respiratory CEDD, GlaxoSmithKline Gunnels Wood Road, Stevenage, Herts, SG1 2NY, UK.

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