Published in Br J Pharmacol on August 01, 1989
Electrophysiological characterization of potent agonists and antagonists at pre- and postsynaptic GABAB receptors on neurones in rat brain slices. Br J Pharmacol (1990) 1.27
Phosphinic acid analogues of GABA are antagonists at the GABAB receptor in the rat anococcygeus. Br J Pharmacol (1991) 0.84
Electrophysiological actions of GABAB agonists and antagonists in rat dorso-lateral septal neurones in vitro. Br J Pharmacol (1996) 0.84
GABA(B) receptor-mediated stimulation of adenylyl cyclase activity in membranes of rat olfactory bulb. Br J Pharmacol (1999) 0.81
Vagal neurotransmission to the ferret lower oesophageal sphincter: inhibition via GABA(B) receptors. Br J Pharmacol (2000) 0.78
The rat anococcygeus muscle and its response to nerve stimulation and to some drugs. Br J Pharmacol (1972) 9.97
Measurements of oxygen consumption in smooth muscle. J Physiol (1953) 5.32
A physiological role for GABAB receptors in the central nervous system. Nature (1988) 2.71
Bicuculline-insensitive GABA receptors on peripheral autonomic nerve terminals. Eur J Pharmacol (1981) 1.94
Phaclofen: a peripheral and central baclofen antagonist. Brain Res (1987) 1.66
GABAA and GABAB receptor-mediated effects in guinea-pig ileum. Br J Pharmacol (1983) 1.47
GABAA- and GABAB-receptor-mediated modification of intestinal motility. Eur J Pharmacol (1982) 1.25
gamma-Aminobutyric acid action in guinea-pig ileal myenteric plexus. Eur J Pharmacol (1982) 1.25
Presynaptic gamma-aminobutyric acid receptors in the rat anococcygeus muscle and their antagonism by 5-aminovaleric acid. Br J Pharmacol (1982) 1.22
gamma-Aminobutyric acid stimulates intrinsic inhibitory and excitatory nerves in the guinea-pig intestine. Eur J Pharmacol (1980) 1.17
The GABAB antagonist phaclofen inhibits the late K+-dependent IPSP in cat and rat thalamic and hippocampal neurones. Brain Res (1988) 1.12
GABA synaptic mechanisms: stereochemical and conformational requirements. Med Res Rev (1988) 0.98
GABA-related activities of amino phosphonic acids on guinea-pig ileum longitudinal muscle. J Auton Pharmacol (1986) 0.87
Phaclofen: a GABAB blocker reduces long-duration inhibition in the neocortex. Eur J Pharmacol (1988) 0.81
Metiamide--an orally active histamine H2-receptor antagonist. Agents Actions (1973) 6.82
Dimaprit -(S-[3-(N,N-dimethylamino)prophyl]isothiourea) - a highly specific histamine H2 -receptor agonist. Part 1. Pharmacology. Agents Actions (1977) 3.33
Chemical differentiation of histamine H1- and H2-receptor agonists. J Med Chem (1975) 3.20
Impromidine (SK&F 92676) is a very potent and specific agonist for histamine H2 receptors. Nature (1978) 2.91
An analysis of the depressor responses to histamine in the cat and dog: involvement of both H1- and H2-receptors. Br J Pharmacol (1975) 2.91
A quantitative study of metiamide, a histamine H2-antagonist, on the isolated whole rat stomach. J Physiol (1976) 2.56
Proceedings: Histamine receptors in the cardiovascular system of the cat. Br J Pharmacol (1974) 2.08
Neural correlates of lexical access during visual word recognition. J Cogn Neurosci (2003) 1.81
Immunological and pharmacological monitoring in the clinical use of cyclosporin A. Lancet (1981) 1.77
Systematic review of abdominal surgery for chronic idiopathic constipation. Colorectal Dis (2011) 1.66
The pharmacology of cimetidine, a new histamine H2-receptor antagonist. Br J Pharmacol (1975) 1.51
The development of rheumatoid arthritis after recombinant hepatitis B vaccination. J Rheumatol (1998) 1.50
The effect of metiamide on acid secretion stimulated by gastrin, acetylcholine and dibutyryl cyclic adenosine 3',5'-monophosphate in the isolated whole stomach of the rat. Br J Pharmacol (1976) 1.48
The effects and side effects of cyclosporine: relationship to drug pharmacokinetics. Transplant Proc (1982) 1.38
Simplified liquid-chromotographic analysis for cyclosporin A, and comparison with radioimmunoassay. Clin Chem (1983) 1.38
Characterization and development of cimetidine as a histamine H2-receptor antagonist. Gastroenterology (1978) 1.35
Electrophysiological characterization of potent agonists and antagonists at pre- and postsynaptic GABAB receptors on neurones in rat brain slices. Br J Pharmacol (1990) 1.27
The effect of an inhibitor of matrix metalloproteinases on colonic inflammation in a trinitrobenzenesulphonic acid rat model of inflammatory bowel disease. Aliment Pharmacol Ther (1999) 1.15
Cyanoguanidine-thiourea equivalence in the development of the histamine H2-receptor antagonist, cimetidine. J Med Chem (1977) 1.10
Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry. Proc Natl Acad Sci U S A (2000) 1.08
The pharmacology of burimamide and metiamide, two histamine H2-receptor antagonists. Fed Proc (1976) 1.07
Peripherally restricted opioid agonists as novel analgesic agents. Curr Pharm Des (2004) 1.05
An investigation into the effect and mechanisms of action of nicotine in inflammatory bowel disease. Inflamm Res (2000) 1.00
Design of potent non-peptide competitive antagonists of the human bradykinin B2 receptor. J Med Chem (1993) 1.00
Studies on gastric acid secretion using an isolated whole mammalian stomach in vitro. J Physiol (1975) 1.00
Investigation of the role of histamine H1-receptors in the control of gastric acid secretion in the rat. J Pharm Pharmacol (1978) 0.99
Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library. Bioorg Med Chem Lett (1998) 0.97
Pharmacology and toxicology of metiamide, a histamine H2-receptor antagonist. S Afr Med J (1974) 0.97
Reduction by cimetidine of acute gastric hemorrhage caused by reinfusion of blood after exposure to exogenous acid during gastric ischemia in rats. Gastroenterology (1979) 0.96
Dimaprit, (S-[3-(N,N-dimethylamino)propyl]isothiourea). A highly specific histamine H2-receptor agonist. Part 2. Structure-activity considerations. Agents Actions (1977) 0.96
Transplantation of haemochromatosis liver and intestine into a normal recipient. Gut (1999) 0.95
Separation of rat muscle aminopeptidases. Biochem J (1976) 0.94
Investigation of the role of extracellular calcium in the control of acid secretion in the isolated whole stomach of the rat. Br J Pharmacol (1979) 0.94
Characterization of the antinociceptive properties of cimetidine and a structural analog. J Pharmacol Exp Ther (1996) 0.93
The effects of Delta-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis. Br J Pharmacol (2010) 0.93
Serum creatine kinase studies in the detection of carriers of Duchenne dystrophy. J Neurol Neurosurg Psychiatry (1971) 0.93
Prevalence of the C282Y mutation of the hemochromatosis gene in liver transplant recipients and donors. Hepatology (1999) 0.92
The effects of adenosine triphosphate and related purines on arterial resistance vessels in vitro and in vivo. Eur J Pharmacol (1989) 0.92
The cardiovascular effects of histamine in laboratory animals. Agents Actions (1974) 0.92
BY 1023/SK&F 96022 INN pantoprazole, a novel gastric proton pump inhibitor, potently inhibits acid secretion but lacks relevant cytochrome P450 interactions. J Pharmacol Exp Ther (1990) 0.92
Inhibition of mature IL-1 beta production in murine macrophages and a murine model of inflammation by WIN 67694, an inhibitor of IL-1 beta converting enzyme. J Immunol (1995) 0.91
Synthesis, specificity, and antifungal activity of inhibitors of the Candida albicans delta 24-sterol methyltransferase. J Med Chem (1992) 0.91
The effect of atropine on acid secretion stimulated by acetylcholine, histamine and gastrin in the isolated whole stomach of the rat. Br J Pharmacol (1977) 0.91
The nonpeptide WIN 64338 is a bradykinin B2 receptor antagonist. Proc Natl Acad Sci U S A (1994) 0.91
Topical and intravenous administration of trefoil factors protect the gastric mucosa from ethanol-induced injury in the rat. Aliment Pharmacol Ther (2000) 0.90
The copper sites of dopamine beta-hydroxylase: an X-ray absorption spectroscopic study. Biochemistry (1988) 0.89
Modulation of the release of endogenous adenosine by cannabinoids in the myenteric plexus-longitudinal muscle preparation of the guinea-pig ileum. Br J Pharmacol (2002) 0.88
Reversible inhibitors of the gastric (H+/K+)-ATPase. 2. 1-Arylpyrrolo[3,2-c]quinolines: effect of the 4-substituent. J Med Chem (1992) 0.88
The design of dipeptide helical mimetics: the synthesis, tachykinin receptor affinity and conformational analysis of 1,1,6-trisubstituted indanes. Bioorg Med Chem (1996) 0.88
Pancreatic spasmolytic polypeptide protects the gastric mucosa but does not inhibit acid secretion or motility. Am J Physiol (1997) 0.87
Zolantidine (SK&F 95282) is a potent selective brain-penetrating histamine H2-receptor antagonist. Br J Pharmacol (1988) 0.87
Further studies on aminopeptidases of rat muscle. Int J Biochem (1979) 0.86
Inhibition by metiamide of secretagogue-induced gastric acid secretion in the conscious Heidenhain pouch rat. J Physiol (1978) 0.86
Reversible inhibitors of the gastric (H+/K+)-ATPase. 5. Substituted 2,4-diaminoquinazolines and thienopyrimidines. J Med Chem (1995) 0.86
Activation of presynaptic A1-receptors by endogenous adenosine inhibits acetylcholine release in the guinea-pig ileum. J Auton Pharmacol (2001) 0.86
Evaluation of a targeted prodrug strategy of enhance oral absorption of poorly water-soluble compounds. Pharm Res (1998) 0.85
Phosphinic acid analogues of GABA are antagonists at the GABAB receptor in the rat anococcygeus. Br J Pharmacol (1991) 0.84
Evidence for both inverse agonism at the cannabinoid CB1 receptor and the lack of an endogenous cannabinoid tone in the rat and guinea-pig isolated ileum myenteric plexus-longitudinal muscle preparation. Br J Pharmacol (2010) 0.84
Icotidine, an antagonist of histamine at both H1 and H2 receptors. N Engl Reg Allergy Proc (1987) 0.84
Preparation and evaluation of peptidic aspartyl hemiacetals as reversible inhibitors of interleukin-1 beta converting enzyme (ICE). Int J Pept Protein Res (1994) 0.84
Skin tags are not a risk factor for colorectal polyps. J Clin Gastroenterol (1989) 0.83
Nitric oxide, an enteric nonadrenergic-noncholinergic relaxant transmitter: evidence using phosphodiesterase V and nitric oxide synthase inhibition. Br J Pharmacol (1995) 0.83
The histamine H2 receptor agonist impromidine: synthesis and structure-activity considerations. J Med Chem (1985) 0.83
Reminiscences of the development of cimetidine. Gastroenterology (1980) 0.83
Ethanol-stimulated acid secretion in the isolated whole stomach of the rat. J Pharm Pharmacol (1980) 0.83
Proceedings: 3-(4(5)-imidazolyl) propylguanidine (SK&F 91486) - a partial agonist at histamine H2-receptors. Agents Actions (1975) 0.83
Adrenergic and purinergic neurotransmission in arterial resistance vessels of the cat intestinal circulation. Eur J Pharmacol (1989) 0.81
ATP-citrate lyase as a target for hypolipidemic intervention. Design and synthesis of 2-substituted butanedioic acids as novel, potent inhibitors of the enzyme. J Med Chem (1996) 0.81
A comparison of the relative activities of a number of GABAB antagonists in the isolated vas deferens of the rat. Br J Pharmacol (1991) 0.81
The effect of hexamethonium on gastric acid secretion in the conscious rat. Agents Actions (1977) 0.81
Investigation of nicotine binding to THP-1 cells: evidence for a non-cholinergic binding site. Biochem Pharmacol (2001) 0.81
Resistance to acid of canine kidney (MDCK) and human colonic (T84) and ileo-caecal (HCT-8) adenocarcinoma epithelial cell monolayers in vitro. Q J Exp Physiol (1989) 0.80
Temporal effect of cyclosporine immunosuppression on T lymphocyte subsets, Ia-reactive cells, and donor-specific immunity in cardiac allograft recipients. Transplant Proc (1984) 0.80
Synthesis and evaluation of (+) and (-)-2,2-difluorocitrate as inhibitors of rat-liver ATP-citrate lyase and porcine-heart aconitase. Eur J Biochem (1991) 0.80
The effects of cannabidiol on the antigen-induced contraction of airways smooth muscle in the guinea-pig. Pulm Pharmacol Ther (2013) 0.80
Structure-activity requirements of bombesin for gastrin-releasing peptide- and neuromedin B-preferring bombesin receptors in rat brain. Eur J Pharmacol (1993) 0.80
Potential histamine H2-receptor antagonists. 2. N-alpha-Guanylhistamine. J Med Chem (1975) 0.79
Inhibition of pepsin secretion by metiamide and atropine in the conscious rat. Agents Actions (1979) 0.79
An alkaline proteinase in muscle homogenates. Biochem J (1971) 0.79
The ethics of treatment decision making: the elderly patient's perspective. The vast resources--and costs--of available technology makes it crucial that we understand what the patient wants. Geriatr Nurs (1994) 0.79
Signaling mechanisms coupled to presynaptic A(1)- and H(3)-receptors in the inhibition of cholinergic contractile responses of the guinea pig ileum. J Pharmacol Exp Ther (2000) 0.79
Lymphocyte subsets in the allograft recipient: correlation of helper to suppressor ratio with clinical events. Transplant Proc (1982) 0.79
Mechanism and inhibition of delta 24-sterol methyltransferase from Candida albicans and Candida tropicalis. Biochemistry (1989) 0.79
Reversible inhibitors of the gastric (H+/K+)-ATPase. 1. 1-Aryl-4-methylpyrrolo[3,2-c]quinolines as conformationally restrained analogues of 4-(arylamino)quinolines. J Med Chem (1990) 0.79
2-[[(4-Amino-2-pyridyl)methyl]sulfinyl]benzimidazole H+/K+-ATPase inhibitors. The relationship between pyridine basicity, stability, and activity. J Med Chem (1989) 0.79
Isoelectric focusing of human liver alkaline phosphatase. Biochem J (1970) 0.79
Characterisation of nicotine receptors on human peripheral blood mononuclear cells (PBMC). Inflamm Res (2009) 0.78
Effects of alpha,beta-methylene ATP on resistance and capacitance blood vessels of the cat intestinal circulation; a comparison with other vasoconstrictor agents and sympathetic nerve stimulation. Eur J Pharmacol (1991) 0.78
Evaluation of a structure-based statine cyclic diamino amide encoded combinatorial library against plasmepsin II and cathepsin D. Bioorg Med Chem Lett (1998) 0.78
Pepsin secretion in the isolated rat stomach preparations [proceedings]. J Physiol (1979) 0.78
Calcium dependence of basal and secretagogue-induced acid secretion in the isolated rat stomach [proceedings]. Br J Pharmacol (1978) 0.78
Subpopulations of GABA-mediated synaptic potentials in slices of rat dorsal striatum are differentially modulated by presynaptic GABAB receptors. Brain Res (1991) 0.78
1976 and all that!--20 years of antisecretory therapy. Gut (1996) 0.78
Properties of the reversible K(+)-competitive inhibitor of the gastric (H+/K+)-ATPase, SK&F 97574. I. In vitro activity. Biochem Pharmacol (1995) 0.78
Comparison of effect of peptide length and sulphation on acid secretory potency of gastrin in the cat in vivo and in vitro. J Physiol (1984) 0.78
The effect of anaesthesia on the inhibition of pentagastrin-evoked gastric acid secretion induced by atropine in the rat. J Physiol (1977) 0.77
'Peptoid' design. Drug Des Discov (1994) 0.76
Small molecule antagonists of the bradykinin B1 receptor. Immunopharmacology (1999) 0.76