Antitumor activity in RAS-driven tumors by blocking AKT and MEK.

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Published in Clin Cancer Res on December 16, 2014

Authors

Anthony W Tolcher1, Khurum Khan2, Michael Ong2, Udai Banerji2, Vassiliki Papadimitrakopoulou3, David R Gandara4, Amita Patnaik1, Richard D Baird2, David Olmos2, Christopher R Garrett3, Jeffrey M Skolnik5, Eric H Rubin6, Paul D Smith5, Pearl Huang6, Maria Learoyd5, Keith A Shannon6, Anne Morosky6, Ernestina Tetteh6, Ying-Ming Jou6, Kyriakos P Papadopoulos1, Victor Moreno2, Brianne Kaiser1, Timothy A Yap2, Li Yan6, Johann S de Bono7

Author Affiliations

1: South Texas Accelerated Research Therapeutics, START Center for Cancer Care, San Antonio Texas.
2: Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, London, United Kingdom.
3: MD Anderson Cancer Center, Houston, Texas.
4: UC Davis Cancer Center, Sacramento, California.
5: AstraZeneca, Alderley Park, Macclesfield, Cheshire, United Kingdom.
6: Merck & Co., Inc., Whitehouse Station, New Jersey.
7: Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, London, United Kingdom. johann.de-Bono@icr.ac.uk.

Associated clinical trials:

A Combination Therapy Study of MK-2206 and AZD6244 in Participants With Advanced Solid Tumors (MK-2206-010) | NCT01021748

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