A requirement for Gch1 and tetrahydrobiopterin in embryonic development.

Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway. Neuron (2015) 0.80

Noradrenaline is essential for mouse fetal development. Nature (1995) 2.84

Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development. Nature (1995) 2.37

Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression. J Biol Chem (2008) 1.72

Tetrahydrobiopterin: biochemistry and pathophysiology. Biochem J (2011) 1.61

Vascular protection by tetrahydrobiopterin: progress and therapeutic prospects. Trends Pharmacol Sci (2008) 1.56

Mutations in the BH4-metabolizing genes GTP cyclohydrolase I, 6-pyruvoyl-tetrahydropterin synthase, sepiapterin reductase, carbinolamine-4a-dehydratase, and dihydropteridine reductase. Hum Mutat (2006) 1.51

Reactive oxygen species mediate endothelium-dependent relaxations in tetrahydrobiopterin-deficient mice. Arterioscler Thromb Vasc Biol (2001) 1.40

Identification of the gene encoding alkylglycerol monooxygenase defines a third class of tetrahydrobiopterin-dependent enzymes. Proc Natl Acad Sci U S A (2010) 1.33

Targeted disruption of the tyrosine hydroxylase locus results in severe catecholamine depletion and perinatal lethality in mice. J Biol Chem (1995) 1.29

An international survey of patients with tetrahydrobiopterin deficiencies presenting with hyperphenylalaninaemia. J Inherit Metab Dis (2012) 1.23

Catecholamines and serotonin are differently regulated by tetrahydrobiopterin. A study from 6-pyruvoyltetrahydropterin synthase knockout mice. J Biol Chem (2001) 1.17

Hyperphenylalaninemia in the hph-1 mouse mutant. Pediatr Res (1988) 1.12

Tetrahydrobiopterin in cardiovascular health and disease. Antioxid Redox Signal (2014) 1.04

Congenic mapping and genotyping of the tetrahydrobiopterin-deficient hph-1 mouse. Mol Genet Metab (2004) 1.04

Uterine artery remodeling and reproductive performance are impaired in endothelial nitric oxide synthase-deficient mice. Biol Reprod (2005) 1.02

Dwarfism and low insulin-like growth factor-1 due to dopamine depletion in Pts-/- mice rescued by feeding neurotransmitter precursors and H4-biopterin. J Biol Chem (2003) 1.02

α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease. Free Radic Biol Med (2013) 0.99

Tetrahydrobiopterin: pleiotropic roles in cardiovascular pathophysiology. Heart (2010) 0.98

Dystonia with motor delay in compound heterozygotes for GTP-cyclohydrolase I gene mutations. Ann Neurol (1998) 0.95

Catecholamines act via a beta-adrenergic receptor to maintain fetal heart rate and survival. Am J Physiol Heart Circ Physiol (2003) 0.95

Tetrahydrobiopterin in the prevention of hypertonia in hypoxic fetal brain. Ann Neurol (2009) 0.88

Identification of Thymosin β4 as an effector of Hand1-mediated vascular development. Nat Commun (2010) 0.88

Clinical and biochemical characterization of patients with early infantile onset of autosomal recessive GTP cyclohydrolase I deficiency without hyperphenylalaninemia. Mov Disord (2010) 0.88

Alkylglycerol monooxygenase. IUBMB Life (2013) 0.85

Analgesia by inhibiting tetrahydrobiopterin synthesis. Curr Opin Pharmacol (2011) 0.85

Perinatal development of endothelial nitric oxide synthase-deficient mice. Biol Reprod (2001) 0.85

Nitric oxide synthase-3 deficiency results in hypoplastic coronary arteries and postnatal myocardial infarction. Eur Heart J (2012) 0.85

The protein partners of GTP cyclohydrolase I in rat organs. PLoS One (2012) 0.81

GTP cyclohydrolase 1 inhibition attenuates vasodilation and increases blood pressure in rats. Am J Physiol Heart Circ Physiol (2003) 0.81

Beneficial prenatal levodopa therapy in autosomal recessive guanosine triphosphate cyclohydrolase 1 deficiency. Arch Neurol (2012) 0.78

Progression of 6-pyruvoyl-tetrahydropterin synthase deficiency from a peripheral into a central phenotype. J Inherit Metab Dis (1990) 0.77

A model for hyperphenylalaninaemia due to tetrahydrobiopterin deficiency. J Inherit Metab Dis (1986) 0.77

Alkylglycerol monooxygenase. IUBMB Life (2013) 0.85

Crucial role for neuronal nitric oxide synthase in early microcirculatory derangement and recipient survival following murine pancreas transplantation. PLoS One (2014) 0.79